A5064648343- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anesthesia and Neurotoxicity Research
- Seismic Imaging and Inversion Techniques
- Geological and Geophysical Studies
- Methane Hydrates and Related Phenomena
- Pain Mechanisms and Treatments
- Nausea and vomiting management
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Tracheal and airway disorders
- Optical Imaging and Spectroscopy Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Muscle activation and electromyography studies
- Spine and Intervertebral Disc Pathology
- Biomedical and Chemical Research
Rakuno Gakuen University
2025
Tohoku Medical and Pharmaceutical University Hospital
2016-2025
Nihon University
2014-2024
Nihon University Itabashi Hospital
2020
Kensei Hospital
2020
Showa University Koto Toyosu Hospital
2015
Showa University
2015
Toho University
2014
Toho University Ohashi Medical Center
2014
Tokyo Women's Medical University
2014
In Brief BACKGROUND: Japan, routine clinical care does not normally involve the use of a monitoring device to guide administration neuromuscular blocking drugs or their antagonists. Although most previous reports demonstrate that sugammadex offers more rapid and reliable antagonism from rocuronium-induced blockade, this advantage has been confirmed in settings when no is used. multicenter observational study, we sought determine whether reduces incidence postoperative residual weakness...
Mirogabalin, which is a selective ligand of the α2δ subunit voltage-gated Ca2+ channels, was recently approved in Japan for peripheral neuropathic pain. The ligands, including mirogabalin and pregabalin, are associated with significant risk adverse events (AEs) such as somnolence or dizziness, leading to poor compliance subsequent inefficacy. Safety efficacy data switching patients from pregabalin scarce. This prospective, single-arm, open-label study involving ten participating centers...
Background Increasing age is associated with a longer duration of action neuromuscular block. The aim this study was to determine the influence ageing on recovery post‐tetanic count ( PTC ) from rocuronium‐induced Methods Twenty‐two younger (20–60 years) and 22 older (> 70 patients were enrolled in study. After induction anaesthesia fentanyl propofol, all initially received 1 mg/kg rocuronium block evaluated by contractions adductor pollicis muscle ulnar nerve train‐of‐four stimulation...
Background Neuromuscular monitoring using the corrugator supercilii muscle is associated with a number of challenges. The aim this study was to assess reversal rocuronium‐induced neuromuscular blockade sugammadex according either or adductor pollicis muscle. We hypothesized that larger dose would be required obtain train‐of‐four ( TOF ) ratio 1.0 than Methods Forty patients aged 20–60 years and 40 ≥ 70 were enrolled. After induction anesthesia, we recorded response facial nerve stimulation...
Aim Although a series of policies have been adapted to deliver an early diagnosis dementia, many people living with dementia remain undetected and undiagnosed. The aim this study is investigate the characteristics in community‐dwelling older Metropolitan Tokyo. Methods We conducted three‐step survey. First, questionnaires were mailed, total, 7614 residents aged ≥70 years one area Tokyo, 5430 retrieved. Secondly, 2020 individuals attended face‐to‐face survey, including Mini‐Mental State Exam...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. Patients inoperative PDAC require effective chemotherapy and pain control to increase their quality of life. We investigated whether duloxetine, serotonin–noradrenaline reuptake inhibitor, improves life in KPPC ( LSL-Kras G12D/+ ;Trp53 flox/flox ;Pdx1-cre ) mouse model PDAC. Six-week-old mice were orally administered 4 mg/kg/d duloxetine (n = 12); 0.15 atipamezole, synthetic α2 adrenergic receptor...
<h3>Background and Objectives:</h3> In addition to their blockade of voltage-dependent sodium channels, the action local anesthetics at 5-hydroxytryptamine-3 (5-HT<sub>3</sub>) receptors may be clinically relevant. Because have different clinical properties, we tested hypothesis that differences in interactions 5-HT<sub>3</sub> receptor relevant by investigating effects 4 on recombinant wild-type mutant 5-HT<sub>3A</sub> receptors. <h3>Methods:</h3> The cRNAs from human subunit clones were...
Background The aim of this study was to evaluate the correlation between cardiac output ( CO ) and reversibility rocuronium‐induced moderate neuromuscular block with sugammadex in elderly patients. Methods Fifty (≥ 65 years) patients were enrolled study. During 1.0–1.5% end‐tidal sevoflurane remifentanil anaesthesia, contraction adductor pollicis muscle response ulnar nerve stimulation acceleromyographically quantified. All initially received 1 mg/kg rocuronium followed by 0.2 whenever...
Postoperative spinal cord injury (SCI) is a devastating complication of surgical repair for thoracoabdominal aortic aneurysm or dissection (TAAD), despite the complex reconstruction inter-costal lumbar arteries involved in surgery. As an alternative technique, endovascular (EVTAR) with visceral artery has been accepted as treatment option severe comorbid patients TAAD, because there permissible frequency SCI after EVTAR spite no arteries. We report results at our hospital focus on injury.We...
Sugammadex 4 mg·kg-1 is recommended for reversal from rocuronium-induced deep neuromuscular block. However, there limited data regarding the dose-response of sugammadex required block in pediatric patients. The aim this study was to determine reversibility with infants and children. Seventy-five children (48 27 children, mean standard deviation (S.D.), age: 11.6 (6.7) months) were enrolled study. After induction anesthesia administration 0.6 rocuronium, acceleromyographically evaluated by...
Ultrasound (US)-guided transversus abdominis plane (TAP) block is used as a part of multimodal analgesic regimen in the postoperative period. Lateral approach TAP (LTAP) has been widely for analgesia after lower abdominal surgeries. Posterior (PTAP), which achieved by more posterior blockade anterior ramus spinal nerve, also provides profound transverse incision. We investigated dermatomal sensory following LTAP and PTAP under US guidance.Twenty-seven adult female patients undergoing...
Background: The aim of this study is to compare the infusion rates required maintain a constant neuromuscular block and reversibility rocuronium at corrugator supercilii muscle (CSM) adductor pollicis (APM). Methods: We randomly allocated 30 female patients into two groups 15 each monitor either CSM or APM. After induction anaesthesia laryngeal mask insertion, contraction facial nerve stimulation that APM ulnar was quantified using an acceleromyograph during 1.0–1.5% end‐tidal sevoflurane...