A5067386743- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Neurotransmitter Receptor Influence on Behavior
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pregnancy-related medical research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Ultrasound in Clinical Applications
- Heart Rate Variability and Autonomic Control
- Shoulder Injury and Treatment
- Pain Management and Treatment
- Veterinary Pharmacology and Anesthesia
- Organic and Inorganic Chemical Reactions
- Cardiac Arrest and Resuscitation
- Photoacoustic and Ultrasonic Imaging
- Musculoskeletal pain and rehabilitation
- Pancreatic and Hepatic Oncology Research
Nihon University
2010-2024
Although midazolam and propofol reduce cerebral blood flow (CBF) similarly, they generate different effects on the autonomic nervous system endothelium-induced relaxation. Midazolam induces sympathetic dominance, whereas parasympathetic dominance. has no effect endothelium-dependent relaxation, suppresses Moreover, apparently constricts arterioles. We therefore hypothesized that have dynamic autoregulation.Ten healthy male subjects received midazolam, propofol, placebo administrations in a...
Background Increasing age is associated with a longer duration of action neuromuscular block. The aim this study was to determine the influence ageing on recovery post‐tetanic count ( PTC ) from rocuronium‐induced Methods Twenty‐two younger (20–60 years) and 22 older (> 70 patients were enrolled in study. After induction anaesthesia fentanyl propofol, all initially received 1 mg/kg rocuronium block evaluated by contractions adductor pollicis muscle ulnar nerve train‐of‐four stimulation...
Ultrasound (US)-guided transversus abdominis plane (TAP) block is used as a part of multimodal analgesic regimen in the postoperative period. Lateral approach TAP (LTAP) has been widely for analgesia after lower abdominal surgeries. Posterior (PTAP), which achieved by more posterior blockade anterior ramus spinal nerve, also provides profound transverse incision. We investigated dermatomal sensory following LTAP and PTAP under US guidance.Twenty-seven adult female patients undergoing...
A prolonged period of oral surgery is a potential risk factor postoperative mental disorders although no such report has been published to date. We retrospectively studied perioperative features in 36 patients who underwent (10 hours or more) surgery. Patients were categorized as pre-delirium (Pre-D) when they manifested 1 2 symptoms and delirium (D) showed more than symptoms, according the modified International Classification Diseases, 10th edition. Of returned normal state without drug...
Background Flumazenil is generally administered to antagonise the sedative effect of midazolam. However, although flumazenil completely antagonises midazolam, a few effects remain unantagonised. Hence, it unclear whether restores attenuation arterial‐cardiac baroreflex (i.e. arterial‐heart rate reflex) induced by We investigated antagonistic after midazolam on cardiac baroreflex, reveal complete recovery from midazolam‐induced sedation administration accompanied restoration midazolam's...
The effects of propofol, a hydrophobic intravenous anaesthetic, and fentanyl, an opiate analgesic, on extracellular concentrations γ-aminobutyric acid (GABA) in the nucleus accumbens rats were studied using vivo brain microdialysis. GABA microdialysate reached stable baseline value approximately 24 h after probe insertion not affected over ensuing 250 min by injection vehicle (1.0 ml/kg) or perfusion tetrodotoxin (2 μM) into via dialysis membrane. Propofol (2.5 mg/kg 10.0 i.v.) did...
IntroductionThe mechanism of complex regional pain syndrome (CRPS) was reported as being related to both the central and peripheral nervous systems. Recurrence CRPS was, reportedly, induced by hand surgery in a patient with upper limb CRPS. However, there is no documentation mechanical allodynia burning abdominal Cesarean section under spinal anesthesia patients
The aim of this study was to determine whether propofol reduces extracellular concentrations dopamine in the rat nucleus accumbens and, if so, effect is potentiated by midazolam. Propofol and midazolam were administered intravenously, via external jugular vein, freely-moving rats. measured consecutively every 25 min using vivo brain microdialysis with electrochemical detection. (2.5, 5.0 10.0 mg/kg) decreased accumbal a dose-dependent manner. largest dose (10.0 concentration maximum 34% (P <...