A5077856294- Cancer, Stress, Anesthesia, and Immune Response
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Neuropeptides and Animal Physiology
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Vascular Anomalies and Treatments
- Fluid Dynamics and Heat Transfer
- Mechanical Circulatory Support Devices
- Chemokine receptors and signaling
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Music Therapy and Health
- Airway Management and Intubation Techniques
- Neuroblastoma Research and Treatments
- Adhesion, Friction, and Surface Interactions
- Surface Modification and Superhydrophobicity
- Pain Mechanisms and Treatments
- Aortic aneurysm repair treatments
- Cardiovascular and Diving-Related Complications
- Pharmacological Effects and Toxicity Studies
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Sedative Agents
Nihon University
2020-2025
Shinshu University
2024
Abstract Introduction: Dysregulation of clock genes has been reported in pancreatic ductal adenocarcinoma (PDAC), but the effects dysregulation on circadian rhythm, PDAC carcinogenesis, progression and prognosis remain unclear. To investigate dysfunctional Bmal1, a major gene, we compared KPPC (LSL-KrasG12D/+; Trp53flox/flox; Pdx-1cre/+) KPPBC Bmal1flox/flox; transgenic mice with PDAC. Methods: Six-week-old were housed wheel cages, rhythms measured until humane endpoint. Tumor status plasma...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. Patients inoperative PDAC require effective chemotherapy and pain control to increase their quality of life. We investigated whether duloxetine, serotonin–noradrenaline reuptake inhibitor, improves life in KPPC ( LSL-Kras G12D/+ ;Trp53 flox/flox ;Pdx1-cre ) mouse model PDAC. Six-week-old mice were orally administered 4 mg/kg/d duloxetine (n = 12); 0.15 atipamezole, synthetic α2 adrenergic receptor...
Introduction Tramadol, a weak opioid anesthetic, is used for pain management in patients with cancer, but the effects of tramadol on cancer via µ-opioid receptor are still unknown. We assessed pancreatic ductal adenocarcinoma using transgenic mice ( LSL-Kras G12D/+ ; Trp53 flox/flox Pdx-1 cre/+ ). Methods Six-week-old were orally administered 10 mg/kg/day (n=12), and 1 naltrexone (n=9), or vehicle water (n=14) until humane endpoint. Cancer-related plasma cytokine levels by mouse grimace...
Biomimetic periodic structures have garnered attention due to their excellent water repellency. The normal-taper angle, which is aspects of the cross-sectional structure, important factor in achieving repellency and pressure resistance; however, underlying physical phenomenon has not been fully explained. Moreover, once a surface becomes hydrophobic, it difficult measure apparent contact angle. purpose this paper clarify taper angle that provides high under impact conditions by formulating...
Mirogabalin, a selective voltage-gated calcium channel α2δ ligand, improves peripheral neuropathic pain; however, its effects on patients with cancers including pancreatic ductal adenocarcinoma (PDAC) remain unknown. We analyzed the of mirogabalin KPPC ( LSL-KrasG12D/+; Trp53flox/flox; Pdx-1cre/+ ) mouse model PDAC. Six-week-old mice received oral (10 mg/kg/day) (n = 10) or vehicle water 14) until humane end point. Cancer-associated pain was evaluated using scores hunching and grimace scale...