A5039101900- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Anesthesia and Sedative Agents
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Nausea and vomiting management
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Intestinal and Peritoneal Adhesions
- Intensive Care Unit Cognitive Disorders
- Abdominal Surgery and Complications
- Gastrointestinal disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Infection Control and Ventilation
- Colorectal Cancer Surgical Treatments
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Hernia repair and management
- Anesthesia and Pain Management
- Clostridium difficile and Clostridium perfringens research
Nihon University
2018-2025
Kyushu University
2020-2021
Suzuki (Japan)
2020-2021
National Institute of Diabetes and Digestive and Kidney Diseases
2021
ProQuest (United States)
2021
National Cancer Center Hospital East
2018-2020
To date, no randomised trials have compared the efficacy of vonoprazan and amoxicillin dual therapy with other standard regimens for Helicobacter pylori treatment. This study aimed to investigate 7-day low-dose as a first-line H. treatment, this vonoprazan-based triple therapy.This prospective, clinical trial was performed at seven Japanese institutions. Patients pylori-positive culture test naive treatment were randomly assigned in 1:1 ratio either VA-dual (vonoprazan 20 mg+amoxicillin 750...
To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in multicenter, randomized, double-blind, investigator-initiated phase III controlled trial.
<b><i>Introduction:</i></b> We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation patients undergoing colonoscopies. <b><i>Methods:</i></b> This multicenter, double-blind, placebo-controlled, phase III included who underwent colonoscopy under with (initial dose: 3 mg; additional 1 mg) or normal saline (placebo). The primary endpoint of the study successful rate during colonoscopy, defined as...
Helicobacter pylori eradication can disrupt the gut microbiome. Here, we investigated short-term impact of minimum antibiotic treatment-a 7-day vonoprazan and low-dose amoxicillin regimen (VA-dual therapy)-on microbiota compared it with that vonoprazan-based triple therapy (VAC-triple therapy).Fifty-nine patients H. infection were recruited (UMIN000034140) from March to May 2019 randomly assigned VAC-triple or VA-dual groups, according first-line treatment received. Fecal samples collected...
Abstract Background As a first‐line therapy for Helicobacter pylori , dual with vonoprazan and amoxicillin (VA‐dual) provides an eradication rate similar to that of vonoprazan‐based triple therapy. the factors associated H. VA‐dual are unknown,we investigated them in this study. Materials Methods Overall, 163 patients diagnosed infection received (vonoprazan 20 mg twice daily 750 7 d). The association between successful following patient clinical was analyzed: sex, age, height, weight, body...
In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra-short-acting benzodiazepine, may reduce recovery time after endoscopic procedures. This study was secondary analysis of the investigator-initiated trial, which investigated efficacy and safety remimazolam in gastrointestinal endoscopy (REM-IICT JP01). Remimazolam administered during upper endoscopy. Patients were divided into two groups: 45...
ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy Japan as a sub‐analysis data from an investigator‐initiated clinical trial remimazolam. Methods Results Patients two groups were matched using propensity score matching. We evaluated time end until discharge, procedure awakening, adverse events. Overall, 36 participants population who underwent 199 patients with during same period included this study. Following matching, 34 both...
Remimazolam is a general anesthetic with short elimination half-life and its pharmacokinetics are less affected by liver kidney function. It may be useful for sedation during endoscopic procedures in patients. This single-arm clinical trial aimed to evaluate the efficacy safety of remimazolam patients undergoing procedures. Patients were included this study. was administered intravenously opioid analgesics, procedure started after an efficient level (Modified Observer's Assessment...
Endoscopic submucosal dissection (ESD) is a widely used treatment for early gastrointestinal cancer. However, colon ESD remains challenging. Previous studies on using the traction method small sample, single-center design, providing insufficient evidence of this procedure's efficacy. We thus aimed to investigate efficacy and safety in multicenter randomized trial.We conducted prospective, multicenter, randomized, two-arm controlled trial at 10 facilities Japan. A 1:1 allocation was...
Remimazolam, an ultra-short-acting benzodiazepine, has been used for procedural sedation in the United States. We conducted investigator-initiated clinical trial to determine appropriate dose of remimazolam required during gastrointestinal endoscopy Japanese subjects.In this single-center, open-label, uncontrolled, phase II trial, a three-stage cohort investigated initial and additional doses endoscopy. This study was designed with advice from Pharmaceuticals Medical Devices Agency. The were...
To compare the efficacy and safety of sedation with midazolam remimazolam for colorectal endoscopy.
Abstract Background Vonoprazan‐based Helicobacter pylori ( H. ) treatment is highly effective in eradicating the target bacteria; however, its post‐1‐year impact on gut microbiota unknown. This study evaluated of vonoprazan‐based therapy 1‐year post‐therapy and investigated relationship between body weight changes perturbations. Materials Methods Between March May 2019, 43 patients with infections received either vonoprazan/amoxicillin (VA) or vonoprazan/amoxicillin/clarithromycin (VAC)...
SUMMARY The Clutch Cutter was invented as a scissor-type knife for endoscopic submucosal dissection (ESD) of gastrointestinal neoplasms. ESD with the (ESD-S) may be considered technically easier procedure than non-scissor-type knives (ESD-NS). Therefore, this study aimed to compare technical outcomes ESD-S those ESD-NS superficial esophageal cancer. This multicenter retrospective study. Patients cancer treated between October 2015 and March 2018 at three hospitals were retrospectively...
Endoscopic submucosal dissection (ESD) for early gastric neoplasms is still a technically difficult and time-consuming procedure. Hybrid ESD (H-ESD) involves circumferential incision with partial combined subsequent mucosal resection by snaring, wherein the newly developed device allows us to perform H-ESD using single device. This study aimed determine clinical outcomes of compared conventional (C-ESD) neoplasms.In this multi-center, retrospective study, propensity score-matched analysis,...
A 59-year-old obese Japanese man with poorly controlled type 2 diabetes mellitus presented severe heartburn for 3 days after inguinal cellulitis and exacerbated glycemic control, without any signs of upper gastrointestinal bleeding. The patient had a high plasma glucose level (34.0 mmol/L) was dehydrated. Emergent esophagogastroduodenoscopy showed black discoloration predominantly affecting the lower esophagus; thus, acute esophageal necrosis (AEN) diagnosed. This not present on 20 prior to...
Minimizing endoscopist exposure to bodily fluids is important for reducing the risk of infection transmission. This study investigated patient-endoscopist vertical distance necessary minimize an endoscopist's facial a patient's visible droplets during upper gastrointestinal endoscopy and ability new device prevent from reaching face.A model was developed simulate patient experiencing forceful cough with endoscopist. Fluorescent dye expelled mouth towards simulated coughs; adhesion face...
The efficacy of transnasal endoscopy using an ultrathin endoscope has been reported in several studies. However, few studies regarding peroral with endoscopes high resolution have reported. This study investigates the pain alleviation endoscope.Patients a history conventional, normal-diameter scope no sedation who underwent esophagogastroduodenoscopy (EGD) thin between April-July 2022 were included this study. After procedure, patients completed questionnaire evaluating during examination...
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Background: Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed self-completion method ESD using Endosaber to eliminate need an additional device or human assistance during procedure. The aim this study was evaluate technical feasibility and outcomes in ex vivo porcine training model. Methods: This pilot study, procedures were performed by 4 experts. Mock lesions measuring 15 mm diameter prepared at posterior wall middle lower...
Eradication of Helicobacter pylori (Hp) is necessary for preventing peptic ulcers and stomach cancer. The potassium-competitive acid blocker vonoprazan a gastric secretion inhibitor that improves the success rate Hp eradication through its immediate persistent inhibition excretion. In Japan, first-line treatment involves regimen in which combined with amoxicillin clarithromycin, while second-line metronidazole. However, contrast to vonoprazan-based therapy, no studies have investigated...