A5034011722- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Anesthesia and Sedative Agents
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Pancreatitis Pathology and Treatment
- Esophageal Cancer Research and Treatment
- Nausea and vomiting management
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Gallbladder and Bile Duct Disorders
- T-cell and B-cell Immunology
- Soft tissue tumors and treatment
- Proteoglycans and glycosaminoglycans research
- Intensive Care Unit Cognitive Disorders
- Intestinal and Peritoneal Adhesions
Kyushu University
2018-2025
Kyushu University Hospital
2019-2025
Harasanshin Hospital
2019-2020
Kitakyushu Municipal Medical Center
2019-2020
National Kyushu Medical Center
2019-2020
Federation University
2015-2019
Fukushima Medical University
2019
Aso Iizuka Hospital
2014-2015
Kyushu Rosai Hospital
2014-2015
To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in multicenter, randomized, double-blind, investigator-initiated phase III controlled trial.
Objectives Endoscopic ultrasound‐guided fine‐needle aspiration/biopsy (EUS‐FNA/B) is the gold standard for diagnosing gastric subepithelial lesions (SELs), but smaller than 20 mm remains challenging. We developed traction‐assisted EUS‐FNB (TA‐EUS‐FNB) using clip‐with‐thread method to enhance diagnostic accuracy by stabilizing lesion and providing counter‐traction easier needle access. This study evaluates effectiveness of TA‐EUS‐FNB in small SELs. Methods In this prospective, randomized,...
Background Cardiac hypertrophy increases the risk of developing heart failure and cardiovascular death. The neutrophil inflammatory protein, lipocalin‐2 ( LCN 2/ NGAL ), is elevated in certain forms cardiac acute failure. However, a specific role for 2 predisposition etiology relevant genetic determinants are unclear. Here, we defined concentric terms pathophysiology, expression networks, genomic determinants. Methods Results We used 3 experimental models: polygenic model failure,...
Mucosal-associated invariant T (MAIT) cells are unconventional that recognize antigens derived from riboflavin biosynthesis. In addition to anti-microbial functions, human MAIT associated with cancers, autoimmunity, allergies and inflammatory disorders, although their role is poorly understood. Activated well known for rapid release of Th1 Th17 cytokines, but we have discovered chronic stimulation can also lead potent interleukin (IL)-13 expression. We used RNA-seq qRT-PCR demonstrate high...
This study aimed to compare the diagnostic yield of mucosal incision-assisted biopsy (MIAB) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) with a rapid on-site evaluation (ROSE) for gastric subepithelial lesions (SEL) suspected being gastrointestinal stromal tumors (GIST) an intraluminal growth pattern.This was prospective randomized, cross-over multicenter study. The primary outcome EUS-FNA MIAB. secondary outcomes were technical success rate, complication procedure time...
<b><i>Introduction:</i></b> We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation patients undergoing colonoscopies. <b><i>Methods:</i></b> This multicenter, double-blind, placebo-controlled, phase III included who underwent colonoscopy under with (initial dose: 3 mg; additional 1 mg) or normal saline (placebo). The primary endpoint of the study successful rate during colonoscopy, defined as...
Abstract Background Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the gold standard for diagnosing gastric alternative open procedures, such as mucosal incision-assisted (MIAB) reported useful. The aim of this study is to evaluate efficacy MIAB diagnosis SELs compared with EUS-FNAB. Methods We retrospectively analyzed medical records 177...
Endoscopic submucosal dissection (ESD) is a widely used treatment for early gastrointestinal cancer. However, colon ESD remains challenging. Previous studies on using the traction method small sample, single-center design, providing insufficient evidence of this procedure's efficacy. We thus aimed to investigate efficacy and safety in multicenter randomized trial.We conducted prospective, multicenter, randomized, two-arm controlled trial at 10 facilities Japan. A 1:1 allocation was...
Abstract Background Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding crucial ensuring safe and reliable procedures. ESD using spray coagulation mode (SCM-ESD) has been developed to control more effectively than conventional forced (FCM-ESD). This study aims compare hemostatic efficacies of SCM-ESD FCM-ESD. Methods multicenter, prospective, parallel, randomized, open-label superiority trial will be...
In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra-short-acting benzodiazepine, may reduce recovery time after endoscopic procedures. This study was secondary analysis of the investigator-initiated trial, which investigated efficacy and safety remimazolam in gastrointestinal endoscopy (REM-IICT JP01). Remimazolam administered during upper endoscopy. Patients were divided into two groups: 45...
ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy Japan as a sub‐analysis data from an investigator‐initiated clinical trial remimazolam. Methods Results Patients two groups were matched using propensity score matching. We evaluated time end until discharge, procedure awakening, adverse events. Overall, 36 participants population who underwent 199 patients with during same period included this study. Following matching, 34 both...
Objectives: Controlling intraoperative bleeding during endoscopic submucosal dissection (ESD) is essential to ensure the safety and reliability of procedure. ESD in spray coagulation mode (SCM-ESD) expected more effective control. This study aimed investigate superiority SCM-ESD over conventional forced (FCM-ESD) terms hemostatic ability for treating early gastric neoplasms (EGNs). Methods: multicenter randomized controlled trial (Spray-G Trial) was conducted at five Japanese institutions....
Gastrointestinal neuroendocrine tumors (GI-NETs) are slow-growing with the potential for malignancy that originate from cells. Therefore, early diagnosis and treatment of GI-NETs necessary to prevent metastasis. The widespread use colonoscopy, which allows detection rectal (rNETs) small enough be treated endoscopically, has resulted in an increasing rate endoscopic resection rNETs. However, whether long-term prognosis endoscopically resected rNETs is favorable not yet been determined. This...
Background and Aims: The complete closure of mucosal defects following colorectal endoscopic submucosal dissection (ESD) is often challenging. We invented a traction-band-assisted (TBEC) technique using clips with an integrated traction band. aimed to evaluate the feasibility TBEC for closing ESD. Methods: This multicenter, prospective, single-arm, pilot study was conducted at three institutions from June 2022 March 2023. Thirty-four patients neoplasms measuring 20-50 mm scheduled ESD were...
Hybrid endoscopic submucosal dissection (H-ESD), which incorporates (ESD) with mucosal resection, has been developed to make ESD technically easier. This study aimed determine if H-ESD is superior conventional (C-ESD) for small early gastric neoplasms (EGNs).We conducted a multi-center, prospective, open-label, randomized controlled trial compare the treatment outcomes of and C-ESD (Hybrid-G Trial). Patients differentiated type intramucosal EGN ≤20 mm in diameter without ulceration were...
To compare the efficacy and safety of sedation with midazolam remimazolam for colorectal endoscopy.
Background and Aim The Japan Narrow‐Band Imaging ( NBI ) Expert Team JNET classification is a recently proposed magnifying endoscopy‐based system for colorectal tumors. Although the usefulness of this has been reported by experts, its objective validity remains unclear. We tested diagnosis polyps including colonoscopy experts non‐experts as test participants. Methods Forty images various types were shown to 22 doctors (11 11 non‐gastrointestinal [ GI ] trainees) who had not examined...
The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors (SNADETs) is controversial.To compare the efficacy and safety mucosal resection (EMR) submucosal dissection (ESD) SNADETs.We retrospectively analyzed data patients with SNADETs from a database treatment SNADETs, which included eight hospitals in Fukuoka, Japan, between April 2001 October 2017. A total 142 treated EMR or ESD were analyzed. Propensity score matching was performed to adjust...
Abstract Gastrointestinal stromal tumors (GISTs) are common subepithelial lesions (SELs) and require treatment considering their malignant potential. We recently developed an endoscopic ultrasound-based artificial intelligence (EUS-AI) system to differentiate GISTs from non-GISTs in gastric SELs, which were used train the system. assessed whether EUS-AI designed for diagnosing could be applied non-gastric GISTs. Between January 2015 2021, 52 patients with SELs (esophagus, n = 15; duodenum,...