A5083725631- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Pesticide and Herbicide Environmental Studies
- Chemical Synthesis and Reactions
- Analytical Chemistry and Chromatography
- Gastric Cancer Management and Outcomes
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Glycosylation and Glycoproteins Research
- Gastrointestinal Tumor Research and Treatment
- Axial and Atropisomeric Chirality Synthesis
- Pharmaceutical and Antibiotic Environmental Impacts
- Endodontics and Root Canal Treatments
- Carbohydrate Chemistry and Synthesis
- Dental Radiography and Imaging
- Metabolomics and Mass Spectrometry Studies
- Inertial Sensor and Navigation
- Catalytic C–H Functionalization Methods
- Mass Spectrometry Techniques and Applications
- Lipid Membrane Structure and Behavior
- Space Satellite Systems and Control
- Sphingolipid Metabolism and Signaling
- Stability and Control of Uncertain Systems
- Analytical Chemistry and Sensors
Kyushu University
2008-2025
Sumitomo Chemical (Japan)
2008-2024
Shibaura Institute of Technology
1997-2024
Showa University Northern Yokohama Hospital
2024
Hokkaido University
2002-2023
Takara (Japan)
2008-2023
Nihon University
2012-2022
Aso Iizuka Hospital
2022
Nagoya University
2005-2020
Keio University
2014-2017
Abstract Hydrogen‐bond (HB)‐donor catalysts that bear a 2‐aminoquinazolin‐4‐(1 H )‐one or 3‐aminobenzothiadiazine‐1,1‐dioxide skeleton have been developed, and it has shown these catalyst motifs act similarly to other HB‐donor such as thioureas. The highly enantioselective hydrazination of 1,3‐dicarbonyl compounds was realized even at room temperature with up 96 % ee for )‐one‐type catalysts, which were more effective than the corresponding urea thiourea catalysts. In addition,...
The left hand claps the right: Highly enantioselective isomerization of racemic α-substituted alkynoates into nonracemic trisubstituted allenoates was achieved through catalytic dynamic kinetic resolution mediated by bifunctional benzothiadiazine. This reaction proceeded with good conversion and high enantioselectivity to give desired in yields without recovering significant amounts starting materials. Detailed facts importance specialist readers are published as "Supporting Information"....
Oligosaccharides possess fascinating functions that are applicable in a variety of fields, such as agriculture. However, the selective synthesis oligosaccharides, especially chitin-oligosaccharides, has remained challenge. Chitin-oligosaccharides activate plant immune system, enabling crops to withstand pathogens without harmful agrichemicals. Here, we demonstrate conversion chitin chitin-oligosaccharides using carbon catalyst with weak acid sites and mechanical milling. The produces up 94 %...
Abstract Background Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding crucial ensuring safe and reliable procedures. ESD using spray coagulation mode (SCM-ESD) has been developed to control more effectively than conventional forced (FCM-ESD). This study aims compare hemostatic efficacies of SCM-ESD FCM-ESD. Methods multicenter, prospective, parallel, randomized, open-label superiority trial will be...
Objectives: Controlling intraoperative bleeding during endoscopic submucosal dissection (ESD) is essential to ensure the safety and reliability of procedure. ESD in spray coagulation mode (SCM-ESD) expected more effective control. This study aimed investigate superiority SCM-ESD over conventional forced (FCM-ESD) terms hemostatic ability for treating early gastric neoplasms (EGNs). Methods: multicenter randomized controlled trial (Spray-G Trial) was conducted at five Japanese institutions....
Tsuji–Trost-type asymmetric allylation of carboxylic acids has been realized by using a cationic CpRu complex with an axially chiral picolinic acid-type ligand (Cl-Naph-PyCOOH: naph = naphthyl, py pyridine). The acid and allylic alcohol intramolecularly condense the liberation water without stoichiometric activation either nucleophile or electrophile part, thereby attaining high atom- step-economy, low E factor. This success can be ascribed to higher reactivity alcohols as compared allyl...
Thiourea makes peptides: Asymmetric Petasis reactions with vinylboronates and α-iminoamides are effectively catalyzed by the novel hydroxy–thiourea catalyst 1 (up to 86 % yield, 93 ee; see scheme). This reaction can be applied not only synthesis of unnatural amino acid monomers but also peptide oligomers. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made available submitted authors. Please note:...
Ceramide is a common precursor of sphingomyelin (SM) and glycosphingolipids (GSLs) in mammalian cells. synthase 2 (CERS2), one the six ceramide isoforms, responsible for synthesis very long chain fatty acid (C20–26 acids) (VLC)-containing ceramides (VLC-Cer). It known that proportion VLC species GSLs higher than SM. To address mechanism VLC-preference GSLs, we used genome editing to establish three HeLa cell mutants expressed different amounts CERS2 compared acyl lengths SM by metabolic...
Shiga toxin (STx) is a virulence factor produced by enterohemorrhagic Escherichia coli. STx taken up mammalian host cells binding to the glycosphingolipid (GSL) globotriaosylceramide (Gb3; Galα1-4Galβ1-4Glc-ceramide) and causes cell death after its retrograde membrane transport. However, contribution of hydrophobic portion Gb3 (ceramide) transport remains unclear. In pigeons, blood group P1 glycan antigens (Galα1-4Galβ1-4GlcNAc-) are expressed on glycoproteins that synthesized...
A cationic CpRu/halogen/Brønsted acid hybrid catalyst (R cat) with the axially chiral Cl-Naph-PyCOOH ligand (naph = naphthyl, py pyridine) is highly efficient for dehydrative cyclization of pyrroles to construct 1,2-fused-2-allylated that, so far, have not been achieved. The mechanistic study has implied that hydrogen and halogen bonds play a key role facilitating R,SRu-catalyzed reaction pathway via σ-allyl intermediate diastereomeric R,RRu cat slowly gives minor enantiomer π-allyl intermediate.
Although detergents are often essential in protocols, they usually incompatible with further biochemical analysis. There several methods for detergent removal, but the procedures complicated or suffer from sample loss. Here, we describe a convenient and rapid method removal sialic acid-containing glycosphingolipids (gangliosides) neutral glycolipids detergent-resistant membrane (DRM) microdomain. It is based on selective extraction, which dried glass tube, followed by washing organic...
Photodegradation of a new strobilurin fungicide, mandestrobin, was investigated in buffered aqueous solution and synthetic humic water (SHW) under continuous irradiation with artificial sunlight (λ > 290 nm). In both aquatic media, the direct photolysis preferentially proceeded via homolytic bond cleavage at benzyl phenyl ether, subsequent recombination geminate radicals solvent cage gave photo-Claisen rearrangement products. A radical mechanism photochemical strongly supported by...
The thermal effect on retention and separation selectivity of inorganic anions aromatic sulfonate ions in anion-exchange chromatography is studied a quaternized styrene–divinylbenzene copolymer column the temperature range 40–120 °C using superheated water chromatography. coefficient for pair identically charged approaches unity as increases provided have same effective size, such that an analyte ion decreases with increase when has stronger affinity ion-exchanger than eluent counterion,...
A new enantioselective catalysis has been developed for the one-step construction of methylene-bridged chiral modules 1,2- and 1,3-OH and/or NH function(s) from δ- or λ-OH/NHBoc-substituted allylic alcohols "H2C═O"/"H2C═NBoc". protonic nucleophile, either in situ-generated CH2OH CH2NHBoc, is intramolecularly allylated to furnish eight possible 1,3-O,O, -O,N, -N,O, -N,N equipped with an ethenyl group high yields enantioselectivities. The utility this method demonstrated five-step synthesis...