A5088196971- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Thin-Film Transistor Technologies
- Silicon Nanostructures and Photoluminescence
- Synthetic Organic Chemistry Methods
- Semiconductor materials and devices
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Click Chemistry and Applications
- Fluorine in Organic Chemistry
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Advanced Synthetic Organic Chemistry
- Silicon and Solar Cell Technologies
- Chemical Reaction Mechanisms
- Copper Interconnects and Reliability
- Synthesis and Reactions of Organic Compounds
- Oxidative Organic Chemistry Reactions
- Diamond and Carbon-based Materials Research
- Sulfur-Based Synthesis Techniques
- Nanowire Synthesis and Applications
- ZnO doping and properties
- Carbohydrate Chemistry and Synthesis
- Synthesis of Indole Derivatives
- Biochemical and Structural Characterization
Tokushima University
2016-2025
Kanazawa University
2001-2021
Institute of Biomedical Science
2017-2018
Kyoto University
2005-2015
Scripps Research Institute
2013-2015
Kyoto Pharmaceutical University
2005
Setsunan University
2005
University of Tsukuba
1989
A thiourea-catalyzed asymmetric Michael addition of activated methylene compounds to α,β-unsaturated imides derived from 2-pyrrolidinone and 2-methoxybenzamide has been developed. In the case derivatives, reaction with malononitrile proceeded in toluene high enantioselectivity, providing adducts good yields. However, nucleophiles that could be used for this were limited due poor reactivity substrate. Further examination revealed N-alkenoyl-2-methoxybenzamide was best substrate among...
The scope, chemoselectivity, and utility of the click-like tyrosine labeling reaction with 4-phenyl-3H-1,2,4-triazoline-3,5(4H)-diones (PTADs) is reported. To study chemoselectivity PTAD derivatives in peptide protein chemistry, we synthesized possessing azide, alkyne, ketone groups studied their reactions amino acid peptides increasing complexity. With proteins compatibility click cysteine lysine-targeted approaches demonstrate that chemoselective trifunctionalization readily achieved. In...
Abstract Hydrogen‐bond (HB)‐donor catalysts that bear a 2‐aminoquinazolin‐4‐(1 H )‐one or 3‐aminobenzothiadiazine‐1,1‐dioxide skeleton have been developed, and it has shown these catalyst motifs act similarly to other HB‐donor such as thioureas. The highly enantioselective hydrazination of 1,3‐dicarbonyl compounds was realized even at room temperature with up 96 % ee for )‐one‐type catalysts, which were more effective than the corresponding urea thiourea catalysts. In addition,...
The NHC-catalyzed thioesterification of aromatic or aliphatic aldehydes with a range thiols was developed in the presence stoichiometric amount an organic oxidant. Among oxidants examined, phenazine shown to give best results terms chemical yield and compatibility thiols.
Tuning the organocatalyst: An unprecedented enantioselective intramolecular oxa-Michael reaction of unactivated α,β-unsaturated amides and esters catalyzed by a powerful hydrogen-bond-donating organocatalyst has been developed. Furthermore, products obtained from this have used for straightforward asymmetric synthesis several natural biologically important compounds. As service to our authors readers, journal provides supporting information supplied authors. Such materials are peer reviewed...
Structure, optical absorption and photoluminescence (PL) properties of SiOx films subjected to thermal annealing at 750–1100 °C are investigated. Si crystallites with a few nanometers in size observed the SiO1.3 SiO1.65 annealed 1100 °C. Threshold energies nanocrystallites higher than that for bulk Si, suggesting contribution from quantum confinement effects. The PL spectrum shows remarkable increase intensity after temperatures above 1000 This behavior is closely related formation by...
We have developed efficient catalytic methods for the stereoselective and diversity synthesis of various (E)-, (Z)-, disubstituted 3-alkylideneoxindoles 3-alkylidenebenzofuran-2-ones via palladium-catalyzed Heck/Suzuki−Miyaura, Heck/Heck, Heck/carbonylation/Suzuki−Miyaura domino reactions.
A bifunctional aminoboronic acid has been used to facilitate for the first time intramolecular aza- and oxa-Michael reactions of α,β-unsaturated carboxylic acids. The combination an arylboronic with a chiral aminothiourea allowed these proceed successfully in enantioselective manner afford desired heterocycles high yields ee's (up 96% ee). overall utility this dual catalytic system was demonstrated by one-pot synthesis (+)-erythrococcamide B, which proceeded via sequential Michael amidation...
The organocatalytic asymmetric Michael addition of organoboronic acids to gamma-hydroxy enones in the presence an iminophenol-type thiourea catalyst is demonstrated. hydroxyl group substrates plays a critical role this reaction.
The left hand claps the right: Highly enantioselective isomerization of racemic α-substituted alkynoates into nonracemic trisubstituted allenoates was achieved through catalytic dynamic kinetic resolution mediated by bifunctional benzothiadiazine. This reaction proceeded with good conversion and high enantioselectivity to give desired in yields without recovering significant amounts starting materials. Detailed facts importance specialist readers are published as "Supporting Information"....
The first enantioselective Neber reaction of β-ketoxime sulfonates catalyzed by a bifunctional thiourea has been developed. proceeds stereoselectively with 5 mol % the catalyst to give 2H-azirine carboxylic esters in good yields up 93% ee. In addition, resulting azirines can be successfully employed stereoselective synthesis di- and trisubstituted aziridines.
Diastereodivergent synthesis of octahydrophenanthridinone and octahydrophenanthridine skeletons, structural motifs often found in biologically active natural products, is described. We previously reported a total pancratistatin analog using novel construction. In this study, we examined the generality our method its extension to formation. Conjugate addition diarylcuprates nitrosocyclohexenes, which were generated situ from 2-chlorocyclohexanone oximes, provided 2-arylcyclohexanone oximes....
Mitochondrial calcium (Ca2+) uptake plays a key role in mitochondrial physiology and disease development. This process is regulated by the uniporter (MCU) complex. DS16570511 membrane-permeable drug that inhibits Ca2+ uptake, although its inhibitory mechanisms remain unclear. In this study, we evaluated effects of on various functions through biochemical analyses. We found affects multiple exhibits variable potency inhibiting individual processes. Specifically, not only MCU, initially...
Amorphous ${\mathrm{SiN}}_{\mathit{x}}$:H films were deposited at 300 \ifmmode^\circ\else\textdegree\fi{}C by rf glow discharge of ${\mathrm{SiH}}_{4}$-${\mathrm{NH}}_{3}$ mixtures, and the SiH SiN stretching absorption investigated as a function N content x. From x dependence intensity, bonding structure was decomposed into five units without H atoms those with atoms, on basis modified random-bonding model. For each unit, oscillator strength bond lengths estimated from values additional...
A practical and efficient methodology for the chemical synthesis of peptides/proteins using a one-pot/sequential ligation is described. It features use photocleavable S-protection on an N-sulfanylethylaniline moiety. Removal S-protecting ligated materials under UV irradiation provides readily usable mixture subsequent native ligation.
Abstract The first efficient methods for the stereoselective synthesis of various ( E )‐, Z and disubstituted 3‐alkylideneoxindoles via radical cyclization reactions were investigated using tandem indium‐mediated carbometallation palladium‐catalyzed cross‐coupling reactions. proper combination substrates reaction conditions is important good yields. key step carboindation strong coordination ability an indium cation to amide carbonyl oxygen. We applied this method TMC‐95A precursor. A new N...
Thiourea makes peptides: Asymmetric Petasis reactions with vinylboronates and α-iminoamides are effectively catalyzed by the novel hydroxy–thiourea catalyst 1 (up to 86 % yield, 93 ee; see scheme). This reaction can be applied not only synthesis of unnatural amino acid monomers but also peptide oligomers. Detailed facts importance specialist readers published as "Supporting Information". Such documents peer-reviewed, copy-edited or typeset. They made available submitted authors. Please note:...
Inhibition of lysine-specific demethylase 1 (LSD1), a flavin-dependent histone demethylase, has recently emerged as new strategy for treating cancer and other diseases. LSD1 interacts physically with SNAIL1, member the SNAIL/SCRATCH family transcription factors. This study describes discovery SNAIL1 peptide-based inactivators LSD1. We designed prepared peptides bearing propargyl amine, hydrazine, or phenylcyclopropane moiety. Among them, peptide 3, displayed most potent LSD1-inhibitory...
The structure of polycrystalline Si (poly-Si) films, prepared by annealing amorphous (a-Si) films deposited using Si2H6, has been investigated x-ray diffraction (XRD), Raman scattering, transmission electron microscopy (TEM), and spin resonance, as functions deposition conditions, such temperature Td (450–580 °C) the a-Si time under a fixed 600 °C. A dominant texture poly-Si changed from 〈100〉 for below 530 °C to 〈111〉 above °C, independent rate film thickness. Although XRD grain size was...
Shifts of the Si 2p, O 1s, and N 1s core-level spectra with or content x for amorphous (a-) ${\mathrm{SiO}}_{\mathit{x}}$ ${\mathrm{SiN}}_{\mathit{x}}$ films were examined by means effective-charge-analysis (ECA) model, in which averaged partial charge ${\mathit{P}}_{\mathit{M}}$(x) (M=Si, O, N) on a given atom is expressed as function x, using Sanderson's electronegativity results random-bonding model (RBM). The effective 2p binding energy ${\mathit{E}}_{\mathit{B}}$(Si 2p) was found to be...