A5061884673- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Tannin, Tannase and Anticancer Activities
- Ginkgo biloba and Cashew Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Chromatography
- Semiconductor Quantum Structures and Devices
- Paraquat toxicity studies and treatments
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Analysis
- Supramolecular Chemistry and Complexes
- Berberine and alkaloids research
- Synthesis and Biological Activity
- Traditional Chinese Medicine Analysis
- Protein Interaction Studies and Fluorescence Analysis
- Inflammatory Myopathies and Dermatomyositis
- Alkaloids: synthesis and pharmacology
- Supramolecular Self-Assembly in Materials
- Eosinophilic Disorders and Syndromes
- Dental Erosion and Treatment
- solar cell performance optimization
Fukuoka University
2021-2024
Fukuyama University
2010-2019
Fukui University of Technology
2007-2008
Osaka City University
1991
General Department of Preventive Medicine
1986
Kyushu University
1986
Chiba University
1983
Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which clinically effective for constipation. Sennoside A transformed into an active metabolite, rheinanthrone, by intestinal bacteria. in rhubarb showed significantly accelerated metabolic activity bacteria comparison with sennoside alone. In this study, we investigated influence constituents on metabolism and purgative A. The 20% MeOH-eluted fraction separated MCI-gel CHP-20P column chromatography from...
Abstract Inclusion complexes of (−)‐epicatechin gallate (ECg) as well (+)‐gallocatechin (GCg) and β‐cyclodextrin (β‐CD) in an aqueous solution were investigated using several NMR techniques a computational method. ECg EGCg formed 1:1 complex with β‐CD, which the A ring portion C included from wide secondary hydroxyl group side β‐CD cavity, B B′ rings left outside cavity. GCg 1:2 by two molecules β‐CD. The difference between modes inclusion ECg, EGCg·β‐CD GCg·β‐CD might have resulted size...
The content of a crude precipitate formed by creaming, which was made from catechin mixture and caffeine, investigated an integral volume H-2 proton signals tea catechins in the (1)H-NMR spectrum. Gallated more predominantly than non-gallated catechins. 2,3-cis-non-gallated (-)-epicatechin (EC) 1:1 complex with 2,3-cis-gallated gallate (ECg) 2:4 caffeine. π-π complexation site EC caffeine only A ring, whereas that ECg included all aromatic rings, A, B, B'. It thought hydrophobicity stronger...
An aqueous solution of equimolecular amounts gallated catechin (-)-epigallocatechin-3-O-gallate (EGCg) and caffeine afforded a crude precipitate by creaming, which crystallized slowly for about three months at 10°C to give colorless block crystal. The crystal was determined be 2 : complex EGCg X-ray crystallographic analysis. formed with the cooperative effect intermolecular interactions, π-π CH-π hydrogen bonds. Upon formation complex, molecule captured hydrophobic space aromatic rings A,...
Abstract Stereochemical structures of a 1:1 complex (−)-epicatechin (EC) and caffeine, 2:4 gallate (ECg) caffeine were determined by X-ray crystallographic analysis, noncovalent interactions forming between EC, ECg moieties also elucidate.
Crystals of the complexes (+)-catechin (CA) non-galloylated catechin and (−)-catechin-3-O-gallate (Cg) galloylated with caffeine were prepared, their stereochemical structures intermolecular interactions determined by X-ray crystallographic analysis. CA formed a 1 : complex hydrogen bonds, whereas Cg 2 caffeine, which was face-to-face offset π–π bonds. A solution two kinds catechin, (−)-epicatechin (EC), (molar ratio 2) in water afforded complex, crystal structure had layers, one layer...
We found that
The structure of inclusion complexes gamma-cyclodextrin (gamma-CD), (-)-gallocatechin gallate (GCg), and (-)-epigallocatechin (EGCg) in D(2)O was investigated using several NMR techniques. GCg formed a 1:1 complex with gamma-CD which the A C rings were inserted deep at head ring into cavity from wide secondary hydroxyl group side. In gamma-CD, moiety maintained conformation B B' took both pseudoequatorial positions respect to ring. obtained experiments supported well that determined PM6...
Abstract Stereochemical structure of a 2:2 complex (−)-epigallocatechin 3-gallate (EGCg) and caffeine, which was the main content crude precipitate formed by creaming, determined X-ray crystallographic analysis, intermolecular interactions forming between EGCg caffeine moieties were elucidated. nicotinamide also determined.
The details of incompatibility between aripiprazole (ARIP) oral solution and green tea were examined. When the ARIP was mixed with a commercial PET bottled beverage, residual rate in decreased to 15.7-17.6%. Mixing reduced content gallate-type polyphenols (GTPs) but not non-gallate-type GTPs. Furthermore, using pH 3.0 lactic acid buffer, 2.23 mM GTP prepared, same volumes mixed. mixed, decreased. On other hand, when did decrease. From above results, it found that main reason for formation an...
Abstract A merohedrally twinned crystal of the complex (−)-gallocatechin gallate and caffeine was prepared in aqueous solution, X-ray crystallographic analysis performed. The driving force for formation thought to be mainly π–π interaction between B′ ring GCg caffeine, B caffeine.
In the 1H-NMR spectrum of a solution containing an equimolecular amount cyclo(L-Pro-Gly), cyclo(D-Pro-Gly) and (−)-epigallocatechin-3-O-gallate (EGCg) in D2O, difference chemical shift signal for H7α, H7β,8α Pro residue was observed. Judging from crystal structures 2 : complexes EGCg cyclo(D-Pro-Gly), resulted mainly magnetic anisotropic shielding effect by ring current B EGCg. Therefore, it considered that chirality cyclo(Pro-Gly) recognized D2O solution. Furthermore, racemic propranolol...
Abstract Nitride laser diodes and light emitting were irradiated with 200‐, 80‐ 10‐MeV protons. The threshold current of violet increased increasing proton fluence to 1 × 10 14 p/cm 2 . increase in is considerably small compared that AlGaAs diodes. Proton energy dependence the change was a little bit different from GaN NIEL. Oscillation wavelength did not before after irradiation. defect levels made by irradiation do seem be radiative recombination centers. (© 2007 WILEY‐VCH Verlag GmbH...
A suspension containing an equimolecular amount of (-)-gallocatechin-3-O-gallate (GCg) and caffeine in water was heated at 90 °C for 30 min to give a 1 : 2 complex GCg caffeine. X-Ray crystallographic analysis crystal the showed that π-π interactions formed between A, B' rings two six-membered Whereas, same s sticky substance, which contained GCg, caffeine, molar ratio 22 based on measurement integral volume (1)H-NMR signals. The substance crystallized slowly C moieties faced each other,...
The formation and steric structure of the inclusion complex cucurbit[ n ]uril (CB[ ]; = 6, 7) diquat (DQ) were investigated through NMR measurements under pH conditions human pseudo-gastric or body fluids, in physiological saline.
In water, diketopiperazines cyclo(L-Pro-L-Xxx) and cyclo(L-Pro-D-Xxx) (Xxx=Phe, Tyr) formed an intramolecular hydrophobic interaction between the main skeleton part their benzene ring, both took a folded conformation. The conformational changes from to extended conformation by addition of several deuterated organic solvents (acetone-d6, metanol-d4, dimethyl sulfoxide-d6 (DMSO-d6)) temperature rise were investigated using 1H-NMR spectra. results suggested that intrarmolecular more strongtly...