A5070212575- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Alkaloids: synthesis and pharmacology
- Synthesis and Biological Activity
- Marine Sponges and Natural Products
- Cancer therapeutics and mechanisms
- Synthesis and bioactivity of alkaloids
- Synthesis and Reactions of Organic Compounds
- Asymmetric Synthesis and Catalysis
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Renal Diseases and Glomerulopathies
- Inorganic and Organometallic Chemistry
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organic Chemistry Cycloaddition Reactions
Hokkaido University
2024
Sapporo University
2024
Children's Medical Center
2015-2022
Fukuyama University
2010-2019
Health Sciences University of Hokkaido
2013-2016
Showa University
2007-2016
Showa University Hospital
2008-2016
Okayama University Hospital
2014
Hiroshima International University
2013
Ehime University
2009
Preterm infants with bronchopulmonary dysplasia often demonstrate sucking difficulties. The aim of this study was to determine whether the severity affects not only coordination among suck-swallow-respiration but also endurance and performance itself.Twenty very low birth weight were studied. Infants anomalies or intraventricular hemorrhage excluded from evaluation. Subjects divided into 3 groups: no (7 infants), without home oxygen therapy (6 infants). In addition efficiency, pressure,...
A one-pot approach to 3,3′-bisindolylmethane derivatives from nitrobenzene through the Bartoli indole synthesis was developed, in which acid used quench reaction markedly affected its outcome. Quenching with concd HCl produced contrast formation of 7-substituted by quenching NH4Cl.
Total syntheses of carazostatin (1), hyellazole (2a), and carbazoquinocins B-F (3b-f) have been completed. The cross-coupling reaction between 3-iodoindole 8 vinylstannane 11b gave the 3-alkenylindole 7. Treatment 7 with ethynylmagnesium bromide, followed by etherification resulting alcohol 12 MOMCl, yielded 3-alkenyl-2-propargylindole 6. compound 6 was treated t-BuOK in t-BuOH at 90 degrees C to obtain desired carbazoles 4 together N-deprotected carbazole 13 through an allene-mediated...
Abstract Background: Extrauterine growth restriction (EUGR) in low‐birthweight (LBW) infants affects their and developmental prognoses as well incidence of adult diseases. The aim the present paper was to determine frequency contributing factors EUGR ≥32 weeks gestational age. Methods: subjects consisted 416 from 22 facilities born between February October 2002, whose age weeks. For assessment, body measurements 37–42 week postmenstrual (PMA) period were below 10th percentile standard normal...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the antitumor antibiotic streptonigrinSteven M. Weinreb, Fatima Z. Basha, Satoshi Hibino, Nazir A. Khatri, Deukjoon Kim, Walter E. Pye, and Tai Teh WuCite this: J. Am. Chem. Soc. 1982, 104, 2, 536–544Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00366a028https://doi.org/10.1021/ja00366a028research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of carbazole alkaloids hyellazole and 6-chlorohyellazoleShinzo Kano, Eiichi Sugino, Shiroshi Shibuya, Satoshi HibinoCite this: J. Org. Chem. 1981, 46, 19, 3856–3859Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/jo00332a019https://doi.org/10.1021/jo00332a019research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of grossularines-1 and -2Tominari Choshi, Shiho Yamada, Eiichi Sugino, Takeshi Kuwada, Satoshi HibinoCite this: J. Org. Chem. 1995, 60, 18, 5899–5904Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00123a028https://doi.org/10.1021/jo00123a028research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract The palladium‐catalyzed tandem cyclization/cross‐coupling reaction of triethyl(indol‐2‐yl)borate with vinyl bromide was successfully used in the concise total synthesis indolophenanthridine alkaloids, calothrixins A and B.
Since the studies of Buhler and Pollack (1), Timpe Runyon (2), Someya Hayashi (3) on an entity believed to be caused by atypical mycobacteria, much attention has been focused such disease. The cases reported as such, however, may have included those a variety diseases, for diagnostic basis disease varied considerably among investigators. Moreover, it difficult differentiate between casual discharge mycobacteria.
The formal total synthesis of murrayaquinone A (1) and the furostifoline (5) were completed by construction 4-oxygenated 3-methylcarbazoles 7 based on a new type electrocyclic reaction through 2-alkenyl-3-allenylindole intermediates 8 derived from 2-alkenyl-3-propargylindoles 9, starting 2-chloroindole-3-carbaldehyde (11). N, O-bisbenzyloxymethyl group 16c 22 underwent Birch reduction followed treatment with Triton B to produce known 4-hydroxy-3-methylcarbazole (7a) 4-hydroxy-3-methylfuro[3,...