A5046318949- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Reactions
- Marine Sponges and Natural Products
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
- Microbial Natural Products and Biosynthesis
- Alkaloids: synthesis and pharmacology
- Synthesis and Biological Activity
- Synthesis and Biological Evaluation
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
- Catalytic C–H Functionalization Methods
- Inorganic and Organometallic Chemistry
- Sulfur-Based Synthesis Techniques
- Organic Chemistry Cycloaddition Reactions
- Synthesis of β-Lactam Compounds
- Cyclopropane Reaction Mechanisms
Pennsylvania State University
2009-2020
Ludwig-Maximilians-Universität München
2019
Wuhan University
2019
Uppsala University
2019
Quaid-i-Azam University
2019
University of Science and Technology of China
2019
University of Nottingham
2019
Shanghai University of Engineering Science
2019
Shandong University of Technology
2019
National Institute of Advanced Industrial Science and Technology
2019
Abstract A convenient method has been developed for directly converting esters to amides using reagents derived from the reaction of trimethylaluminum with ammonium chloride, methylamine hydrochloride or dimethylamine hydrochloride.
[3 + 2]-Cycloadditions of alkyl azides with various unsymmetrical internal alkynes in the presence Cp*RuCl(PPh3)2 as catalyst refluxing benzene have been examined, leading to 1,4,5-trisubstituted-1,2,3-triazoles. Whereas phenyl and dialkyl acetylenes undergo cycloadditions afford mixtures regioisomeric 1,2,3-triazoles, acyl-substituted react complete regioselectivity. In addition, propargyl alcohols amines were found single products.
What the Heck: The heptacyclic fungal alkaloid communesin F was target of a total synthesis featuring rare example an intramolecular Heck cyclization tetrasubstituted alkene, reductive N-Boc aniline, stereoselective C allylation lactam, and azide reduction/N-Boc-δ-lactam ring opening sequence (see scheme, BOM=benzyloxymethyl).
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal syntheses of aflatoxins M1 and G1 an improved synthesis aflatoxin B1George Buechi Steven M. WeinrebCite this: J. Am. Chem. Soc. 1971, 93, 3, 746–752Publication Date (Print):February 1, 1971Publication History Published online1 May 2002Published inissue 1 February 1971https://pubs.acs.org/doi/10.1021/ja00732a032https://doi.org/10.1021/ja00732a032research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of cephalotaxineJoseph Auerbach and Steven M. WeinrebCite this: J. Am. Chem. Soc. 1972, 94, 20, 7172–7173Publication Date (Print):October 1, 1972Publication History Published online1 May 2002Published inissue 1 October 1972https://pubs.acs.org/doi/10.1021/ja00775a062https://doi.org/10.1021/ja00775a062research-articleACS PublicationsRequest reuse permissionsArticle Views961Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the Cephalotaxus alkaloids. Cephalotaxine, cephalotaxinone, and demethylcephalotaxinoneSteven M. Weinreb Joseph AuerbachCite this: J. Am. Chem. Soc. 1975, 97, 9, 2503–2506Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/ja00842a030https://doi.org/10.1021/ja00842a030research-articleACS PublicationsRequest reuse permissionsArticle...
A new phenolic derivative of aflatoxin B(1), appearing mainly in conjugated form, was identified as the principal urinary metabolite B(1) rhesus monkeys. Its identification human urine might facilitate estimation exposure populations.
ADVERTISEMENT RETURN TO ISSUEPREVNotetert-Butylsulfonyl (Bus), a New Protecting Group for AminesPu Sun, Steven M. Weinreb, and Maoyu ShangView Author Information Department of Chemistry, The Pennsylvania State University, University Park, 16802 Chemistry Biochemistry, Notre Dame, Indiana 46556 Cite this: J. Org. Chem. 1997, 62, 24, 8604–8608Publication Date (Web):November 28, 1997Publication History Received5 August 1997Published online28 November inissue 1...
Cylindrospermopsin (CY), a sulfate ester of tricyclic guanidine substituted with hydroxymethyluracil, is cyanobacterial toxin increasing environmental import as it frequently occurs in drinking water reservoirs. As toxin, CY mainly targets the liver but also involves other organs. In hepatocytes inhibits synthesis protein and glutathione, leading to cell death. The total chemical has recently been reported (Xie et al., 2000, J. Am. Chem. Soc. 22, 5017–5024). provided analogues study aspects...
The first total synthesis of the cytotoxic marine metabolite agelastatin A (1) has been achieved in about 14 steps performed 12 operations approximately 7% overall yield starting from cyclopentadiene. Hetero Diels−Alder cycloaddition cyclopentadiene with N-sulfinyl methyl carbamate (7) afforded cycloadduct 8, which without purification was converted to allylic sulfoxide 9 and then by a [2,3]-sigmatropic rearrangement into bicyclic oxazolidinone 11. C-5a nitrogen introduced Boc derivative 16...
N-Phosphinoylimines have recently begun to attract significant attention from synthetic chemists for the preparation of nitrogen-containing molecules. Several methods been developed synthesis, or in situ generation, these reactive electrophilic species. undergo a wide range reactions, including nucleophilic additions and cycloadditions. These imines are also effective electrophiles number diastereoselective enantioselective reactions. An advantage using N-phosphinoylimines is that reaction...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExploratory studies of the transition metal catalyzed intramolecular cyclization unsaturated .alpha.,.alpha.-dichloro esters, acids, and nitrilesThomas K. Hayes, Rosanna. Villani, Steven M. WeinrebCite this: J. Am. Chem. Soc. 1988, 110, 16, 5533–5543Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition of Grignard and organolithium reagents to N-sulfonyl aldimines generated in situ from aldehydes N-sulfinylsulfonamidesJoseph Sisko Steven M. WeinrebCite this: J. Org. Chem. 1990, 55, 1, 393–395Publication Date (Print):January 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00288a080https://doi.org/10.1021/jo00288a080research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloid total synthesis by intramolecular imino Diels-Alder cycloadditionsSteven M. WeinrebCite this: Acc. Chem. Res. 1985, 18, 1, 16–21Publication Date (Print):January 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ar00109a004https://doi.org/10.1021/ar00109a004research-articleACS PublicationsRequest reuse permissionsArticle Views972Altmetric-Citations92LEARN ABOUT THESE...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the aromatic and monosaccharide moieties staurosporineRichard P. Joyce, James A. Gainor, Steven M. WeinrebCite this: J. Org. Chem. 1987, 52, 7, 1177–1185Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/jo00383a001https://doi.org/10.1021/jo00383a001research-articleACS PublicationsRequest reuse permissionsArticle...