A5084681164- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Metabolism and Genetic Disorders
- RNA Research and Splicing
- Folate and B Vitamins Research
- Physical Activity and Health
- Herpesvirus Infections and Treatments
- Amino Acid Enzymes and Metabolism
- Epilepsy research and treatment
- Hereditary Neurological Disorders
- Peroxisome Proliferator-Activated Receptors
- Myasthenia Gravis and Thymoma
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular and exercise physiology
- Polyomavirus and related diseases
- RNA and protein synthesis mechanisms
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- Cardiac Health and Mental Health
- Multiple Sclerosis Research Studies
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
Kitasato University
2014-2024
Kitasato University Hospital
1994-2020
National Sagamihara Hospital
2019
Shizuoka City Shimizu Hospital
2017
Fukushima Medical University Hospital
2017
Ehime Prefectural Central Hospital
2017
Nippon Medical School
2017
keiyu Hospital
2017
National Center of Neurology and Psychiatry
2000-2007
Aichi Health Promotion Foundation
2004-2007
To report the distinctive clinical features of cryptogenic new-onset refractory status epilepticus (C-NORSE) and C-NORSE score based on initial assessments.A retrospective study was conducted for 136 patients with clinically suspected autoimmune encephalitis who underwent testing autoantibodies to neuronal surface antigens between January 1, 2007, August 31, 2016. Eleven were identified. Their compared those 32 anti-NMDA receptor (NMDARE).The outcome 11 (median age, 27 years; 7 [64%] women)...
<h3>Importance</h3> Anti-<i>N</i>-methyl-d-aspartate receptor (NMDAR) encephalitis is an immune-mediated disorder that occurs with IgG antibodies against the GluN1 subunit of NMDAR. Some patients develop reversible diffuse cerebral atrophy (DCA), but long-term clinical significance progressive brain and cerebellar unknown. <h3>Objective</h3> To report implications DCA in anti-NMDAR encephalitis. <h3>Design, Setting, Participants</h3> A retrospective observational study imaging investigation...
A variety of neuronal surface (NS) antibodies (NS-Ab) have been identified in autoimmune encephalitis (AE). Tissue-based assay (TBA) using a rodent brain immunohistochemistry (IHC) is used to screen NS-Ab, while cell-based (CBA) determine NS antigens. Commercial rat IHC currently available but its clinical relevance remains unclear. Immunostaining patterns antigens not extensively studied yet. To address these issues, we assessed predictive value “neuropil pattern” and “GFAP on commercial...
A 29-year-old man developed acute cerebellar ataxia following Epstein-Barr virus infection. Serum IgG and IgM antibodies reacted with both nuclear cytoplasmic elements of neurons. Western blot revealed binding to the 34- 29-kd bands 44-, 37-, bands. The reactivity gradually reduced. There was no identifiable neoplasm improved. These findings suggest a role for autoimmune mechanisms in pathogenesis ataxia.
To determine whether a clinically based score predicts cryptogenic new-onset refractory status epilepticus (C-NORSE) at the early stage of (SE) with prominent motor symptoms (SE-M) unclear etiology.The (range 0-6) included 6 clinical features: highly refractoriness to antiseizure drugs, previously healthy individual, presence prodromal fever, absence psychobehavioral or memory alterations, dyskinesias, and symmetric brain MRI abnormalities (the first 2 mandatory). We retrospectively assessed...
Abstract Objectives Status epilepticus (SE) can be associated with neuronal surface antibodies (NS‐Abs) but NS‐Ab detection rate remains unknown in patients SE of unclear etiology at symptom presentation suspected having an autoimmune (SE autoimmune). We aimed to determine the and clinical features that predict presence NS‐Abs autoimmune. Methods retrospectively reviewed information 137 who underwent testing for between January 2007 September 2020. were examined both serum cerebrospinal...
The effects of exercise in subjects with multiple cardiovascular risk factors (RF) have never been tested a large-scale randomized controlled trial. favorable results from our observational study led to this trial.The participants, recruited community, were overweight, two the following three factors: hypertension, hyperlipidemia, or glucose intolerance (N=561; 44% male; mean age (SD) 67 (6); BMI 26.4 (2.0)). All participants received standard health exam counseling, followed by...
Hyperornithinemia, hyperammonemia and homocitrullinuria (HHH) syndrome presents with various neurological symptoms, including mental retardation, spastic paraparesis pyramidal signs, cerebellar ataxia, episodic disturbance of consciousness or coma caused by hyperammonemia. We report three novel mutations in the mitochondrial ornithine transporter gene (ORNT1) Japanese patients HHH syndrome: a nonsense mutation (R179X) associated exon skipping frameshift, missense (G27E), an insertion AAC...
Background Obesity is a risk factor for episodic migraine to develop into chronic migraine; hence, it speculated that obesity and hyperleptinemia are associated with migraine. We hypothesized leptin involved in the mechanisms of cortical spreading depression (CSD). Therefore, we examined whether affected rat model CSD clarify relationship between Methods evaluated effect intracerebroventricular (ICV) administration on model. then once-a-day intraperitoneal seven days (as model) models....
Abstract Objective To investigate the nature of prodromal headache in anti‐ NMDA receptor ( NMDAR ) encephalitis. Methods Retrospective review clinical information 39 patients with encephalitis admitted between January 1999 and September 2017. Five an atypical presentation were excluded. Thus, 34 (median 27 years [range, 12–47 years]; 28 [82%] female), features compared who initially reported those did not report. Results Twenty‐two (65%) either transiently n = 5) or continuously 17)....
Abstract: Plasmapheresis is widely performed as treatment for patients with Guillain–Barré syndrome (GBS) in the acute phase. As tryptophan‐immobilized column‐based immunoadsorption (Tr‐IA) a safer method than either double‐filtration plasmapheresis (DFPP) or plasma exchange (PE), we investigated whether not Tr‐IA effective other methods, and should be selected procedure of choice GBS. We retrospectively compared clinical outcomes, using Hughes grading, GBS treated Tr‐IA, DFPP PE. The...
One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature. However, the relationship between temperature remains unclear. Therefore, we investigated body cortical spreading depression (CSD) using KCl-induced rat models CSD. We initially CSD under controlled conditions at a room 28°C on an operating table maintained 37°C. Subsequently, induce second round either...
Autoimmune encephalitis (AE) is an immune-mediated characterized by the subacute onset of memory deficits, altered mental status, or psychiatric symptoms. Limbic associated with rheumatoid arthritis (RA) has not been reported yet. A 57-year-old man presented headache, depression, and anorexia 7 months before RA. Brain magnetic resonance imaging showed symmetric parenchymal lesions involving medial temporal lobes. He was diagnosed RA AE, but no autoantibodies to neuronal intracellular...
Introduction Anti-NMDA receptor encephalitis is an autoimmune disorder caused by autoantibodies (abs) against the conformational epitope on GluN1 subunits. GluN1-abs have been determined with cell-based assay (CBA) co-expressing GluN1/GluN2 However, commercial fixed CBA expressing only subunit has increasingly used in clinical practice. The ab titers can be serial dilutions, but its significance remains unclear. We aimed to develop H-intensity scale (HIS) score estimate GluN1-ab...