A5084518880- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Microwave-Assisted Synthesis and Applications
- Chemical Synthesis and Analysis
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Synthesis and Biological Evaluation
- Neural and Behavioral Psychology Studies
- Chemical Reactions and Isotopes
- Glioma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- EEG and Brain-Computer Interfaces
- Fluorine in Organic Chemistry
- Memory and Neural Mechanisms
- HER2/EGFR in Cancer Research
- Lanthanide and Transition Metal Complexes
- Pain Mechanisms and Treatments
- Gyrotron and Vacuum Electronics Research
- Lung Cancer Treatments and Mutations
- Metabolism and Genetic Disorders
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
Karolinska Institutet
2010-2020
Karolinska University Hospital
2009-2018
Science for Life Laboratory
2015
Stockholm University
1989-2002
KTH Royal Institute of Technology
2002
Linköping University
1997
Swedish Heart-Lung Foundation
1997
Medical Research Council
1997
Knut and Alice Wallenberg Foundation
1997
Cambridge University Press
1996
This study was undertaken to explore whether the neural substrates demonstrated in brain imaging studies on experimentally induced pain are involved perception of chronic neuropathic pain. We investigated cerebral representation lateralised ongoing patients with painful mononeuropathy (PMN, i.e., distribution a nerve, neuralgia) positron emission tomography (PET), using regional blood flow (rCBF) as an index for neuronal activity. Eight (29-53 years) PMN lower extremity (4 right, 4 left)...
• Several groups have reported increased densities of D<sub>2</sub>dopamine receptors in the basal ganglia schizophrenic brains postmortem. The significance this finding has been questioned, since an upregulation receptor number may be a neuronal response to neuroleptic drug treatment. We used positron emission tomography and [<sup>11</sup>C]raclopride examine central binding 20 healthy subjects 18 newly admitted, young, neuroleptic-naive patients with schizophrenia. An vivo saturation...
It has previously been suggested that the activity in sensory regions of brain can be modulated by attentional mechanisms during parallel cognitive processing. To investigate whether such attention-related modulations are present processing pain, regional cerebral blood flow was measured using [(15)O]butanol and positron emission tomography conditions involving both pain demands. The painful stimulus consisted standard cold pressor test task a computerised perceptual maze test. activations...
WE measured regional cerebral blood flow (rCBF) with positron emission tomography to study changes in anatomical structures during the course of learning a complicated finger sequence voluntary movements. Motor was accompanied by rCBF increases cerebellum, decreases all limbic and paralimbic structures, striatal which changed as motor skill learned. Simultaneously, activations initially contributing non-motor parts cortex vanished. Both cerebellar circuits appear important for storage skills brain.
Selective irreversible inhibitors of selenoprotein TXNRD1 yield anticancer efficacy without overt systemic toxicity in mouse models.
The study was conducted to investigate which areas of the brain respond a painful encounter minor dermal injury (a model clinical pain) elicited by intracutaneous injection minute amount ethanol. Four healthy volunteers (27-46 years) were subjected positron emission tomographic (PET) investigation regional cerebral blood flow (rCBF), using [15O]butanol as tracer. ethanol (20 microliters, 70%) and saline 0.9%) injected intracutaneously 3 times in single-blinded, semi-randomised manner for...
1. We used functional positron emission tomography (PET), measuring regional cerebral blood flow (rCBF) as an index of neuronal activity, to investigate the central processing itch in 10 healthy volunteers subjected intracutaneous injections histamine. 2. The study has unraveled a representation that depicts motor intention urge scratch contingent on perception unpleasant itch. coactivation anterior cingulate cortex (ACC), supplementary area (SMA), premotor (PM), and inferior parietal lobule...
Abstract We investigated central nervous system correlates of simple phobie fear, Regional cerebral blood flow (rcBF) was measured using position emission tomography(PFT) in eight volunteers with symptomatic spider phobia that were exposed to visual phobogenic and neutral stimuli Diazepam (0.1 mg/kg body weight i.v.) or placebo administered under double blind conditions after initial PFT scans. The scans then repeated. presence fear confirmed by rating procedures increased number nonspecific...
Human epidermal growth factor receptor type 2 (HER2) is a tyrosine kinase, which often overexpressed in many carcinomas. Imaging HER2 expression malignant tumors can provide important prognostic and predictive diagnostic information. The use of anti-HER2 tracers labeled with positron-emitting radionuclides may increase the sensitivity imaging. goal this study was to compare directly approaches for developing PET tracers: (124)I-labeled monoclonal antibody small (7-kDa) scaffold protein,...
The objective of this study was to investigate the central processing dynamic mechanical allodynia in patients with mononeuropathy. Regional cerebral blood flow, as an indicator neuronal activity, measured positron emission tomography. Paired comparisons were made between three different states; rest, during brushing painful skin area, and homologous contralateral area. Bilateral activations observed primary somatosensory cortex (S1) secondary (S2) compared rest. S1 activation site stimulus...
Recent PET results indicate that the benzodiazepine (BZ) receptor density measured with BZ antagonist [11C]flumazenil is reduced in human epileptic foci. The present study examines applicability of this finding presurgical investigation patients intractable partial epilepsy. In eight patients, measurements were performed after injection and [2-18F]2-deoxy-2-fluoro-D-glucose ([18F]FDG)--a tracer for rate regional glucose metabolism. focus localising ability two tracers was examined using...
Abstract This study of somatosensory discrimination rectangular parallelepipeds with the right hand had three purposes: (i) to describe exploratory finger movements; (ii) reveal anatomical brain structures specifically engaged in production and (iii) tactually sensed shape. The thumb was most active finger, moving a mean exploration frequency 2.4 Hz, as evident from videotape records movements. cerebral activated during were mapped by measurements regional blood flow (rCBF) six healthy male...
An experimental drug, 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine, that facilitates glutamatergic transmission in brain after systemic administration was tested for its effects on the induction of long-term potentiation hippocampus rats. Intraperitoneal injections drug markedly increased degree and duration potentiation; similar results were obtained with an analogue 1-(1,3-benzodioxol-5-ylcarbonyl)piperidine also found to improve retention memory a radial maze task odor-matching problem....
Abstract The pattern of brain perfusion four patients with writer's cramp and control subjects were examined using positron emission tomography scans after [ 15 O] butanol injections. Each subject was scanned 12 times to cover three repetitions different motor tasks the right hand. Drawing horizontal lines variable durations writing a prelearned text performed in pseudorandom order, latter task commencing either simultaneously or 30 sec 120 before tracer injection. perceived difficulty signs...
Abstract Positron emission tomographic measurements of regional cerebral blood flow (rCBF) were used to investigate central nervous system correlates fear and anxiety. Volunteers with symptomatic snake phobia studied while exposed visual phobogenic, aversive, neutral stimuli. Anxiety ratings the number nonspecific electrodermal fluctuations increased as a function phobic stimulation. Phobic, compared stimulation elevated rCBF in associative cortex. The basal ganglia not activated more by...
Regional brain glucose metabolism was investigated in healthy volunteers (n = 10) and drug free schizophrenic patients 20). The determined by positron emission tomography (PET) with 11C-glucose as the tracer. Diagnosis of schizophrenia made according to RDC DSM III. Eight had their first psychotic episode, four a subchronic course eight chronic an exacerbation illness. Computed (CT) were all subjects. Regions interest 35) drawn on displayed CT images marked regions transferred corresponding...