A5048350841- Pharmacological Effects and Toxicity Studies
- Pregnancy and Medication Impact
- Epilepsy research and treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmaceutical studies and practices
- Pregnancy and preeclampsia studies
- Child and Adolescent Psychosocial and Emotional Development
- Viral Infections and Vectors
- Prenatal Substance Exposure Effects
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Cholesterol and Lipid Metabolism
- Biosimilars and Bioanalytical Methods
- Hormonal Regulation and Hypertension
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Acute Lymphoblastic Leukemia research
- Metabolism and Genetic Disorders
- Ocular Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Polyomavirus and related diseases
- Neonatal and fetal brain pathology
- Nitric Oxide and Endothelin Effects
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
Karolinska Institutet
2014-2023
Karolinska University Hospital
2011-2023
Helsinki Children's Hospital
2021
University of Helsinki
2021
Sachs' Children and Youth Hospital
1981-2000
Aim : Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) monotherapy. Methods Infants exposed ( n = 1398) early pregnancy were identified from Swedish Medical Birth Registry. number infants with congenital malformations AED compared expected estimated all born 582656). Results 90% (1256) children monotherapy, 56% CBZ 21% VPA. odds...
Major depression occurs in 5–10% of pregnancies and is associated with many negative effects for mother child, yet treatment options are scarce. To our knowledge, this the first published randomised controlled trial on Internet delivered Cognitive Behavior Therapy (ICBT) group. test efficacy a pregnancy adapted version an existing 10-week ICBT-program as well assessing acceptability adherence Randomised trial. Online telephone. Self-referred pregnant women (gestational week 10–28 at intake)...
To estimate the rate of admissions to NICUs, as well infants' morbidity and neonatal interventions, after exposure antidepressant drugs in utero.Data on pregnancies, deliveries, prescription drug use, health status newborn infants were obtained from Swedish Medical Birth Register, Prescribed Drug Neonatal Quality Register. We included 741 040 singletons, born between July 1, 2006, December 31, 2012. Of infants, 17 736 (2.4%) had mothers who used selective serotonin reuptake inhibitors...
Background Intrauterine exposure to antidepressants may lead neonatal symptoms from the central nervous system, respiratory system and gastrointestinal system. Finnegan score (Neonatal Abstinence Score, NAS) has routinely been used assess infants exposed in utero. Aim The purpose was study maladaptation syndrome selective serotonin reuptake inhibitors (SSRI) or serotonin-norepinephrine (SNRI) Method Retrospective cohort of women using during pregnancy their infants. Patients were identified...
We aimed to study whether antipsychotic use during pregnancy is associated with gestational diabetes. This was a Swedish national register‐based cohort on the Medical Birth Register and Prescribed Drug including all 1,307,487 singleton births between July 2006 December 2017. Antipsychotics were divided into first-generation antipsychotics (n = 728), high-risk metabolic second-generation olanzapine, clozapine quetiapine 1710), other 541). The risks for diabetes, foetal growth disturbances,...
The aim of this study was to assess psychomotor development with the Griffiths' test in preschool children exposed antiepileptic drags (AED) utero . sample consisted 76 AED and 71 unexposed children. (exposed unexposed) have since birth been included a population‐based longitudinal follow‐up born women meticulously treated epilepsy during pregnancy, initiated 1985. In total, 67 66 were tested test, which consists 6 subsets: locomotor function, personal social behaviour, hearing speech, eye...
The aim of this study was to assess psychomotor development, using Griffiths' test, and the incidence minor anomalies at birth in children who had been exposed antiepileptic drugs (AEDs) utero. sample comprised 100 mothers were treated with AEDs during pregnancy matched control children. Women epilepsy recruited from a pregnant urban population (450 000 inhabitants). lowest possible dose fewest maintain seizure used. Drug levels controlled on monthly basis. assessed 9 months age. significant...
Abstract The distal 3p deletion syndrome is characterized by developmental delay, low birth weight and growth retardation, micro‐ brachycephaly, ptosis, long philtrum, micrognathia, set ears. We have used FISH BACs in order to map three deletions detail at the molecular level. were 10.2–11 Mb size encompassed 47–51 known genes, including VHL gene. One of was interstitial, with an intact telomere. In nine previously published patients deletions, estimated using or cytogenetic techniques....
Aim To compare plasma 4β‐hydroxycholesterol : cholesterol with urinary 6β‐hydroxycortisol cortisol as markers of cytochrome P4503A4 activity before and after treatment rifampicin for 2 weeks. Method were determined by liquid chromatography tandem mass spectrometry was gas chromatography–mass in three groups healthy volunteers. Results Induction ratios 1.8, 3.9 4.5 20 mg day −1 , 100 or 500 rifampicin, respectively. The corresponding 1.5, 2.4 3.8. Conclusions Plasma gave similar induction to cortisol.
Background: Therapeutic drug monitoring of antiepileptic drugs in children with epilepsy assists for personalized therapy but require numerous patient visits venous blood sampling. DBS is an alternative matrix applicable to home sampling which can save time and reduce stress this group. Results: A fast LC–MS/MS method quantification carbamazepine, lamotrigine valproic acid based on was developed. The showed linearity therapeutically relevant concentration ranges compatible unknown volume...
Background: Exposure in utero to certain medications can disrupt processes of fetal development, including brain leading a continuum neurodevelopmental difficulties. Recognizing the deficiency investigations within pregnancy pharmacovigilance, an international Neurodevelopmental Expert Working Group was convened achieve consensus regarding core outcomes, optimization methodological approaches and barriers conducting pharmacovigilance studies with outcomes. Methods: A modified Delphi study...
Summary: Purpose : To investigate the influence of maternal antiepileptic drug (AED) treatment on pregnancy duration, birth weight, body length, head circumference, and intrauterine growth in infants exposed utero to drugs Sweden between 1973–1997, with 963 singleton infants. Methods Data collected from (a) 1973–1981 (record linkage a hospital discharge register medical register); (b) 1984–1995 (prospectively information one defined catchment area two delivery hospitals); (c) 1995–1997...
Aim: Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) monotherapy. Methods: Infants exposed (n= 1398) early pregnancy were identified from Swedish Medical Birth Registry. number infants with congenital malformations AED compared expected estimated all born 582656). Results: 90% (1256) children monotherapy, 56% CBZ 21% VPA. odds...
Abstract Aim. To study the risk for complications during pregnancy, delivery, and neonatal period after use of antiepileptic drugs (AEDs) pregnancy. Methods. Women treated with AEDs pregnancy singleton deliveries were identified from Swedish Medical Birth Registry July 1 1995 to including 2001 (n = 1350). Risk estimates made using Mantel‐Haenszel procedure comparisons all births in Sweden this 559 491). Stratification was year birth, maternal age, parity, smoking habits. Results. Most women...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • CYP3A4 converts cholesterol into 4β‐hydroxycholesterol. We have suggested that 4β‐hydroxycholesterol could be used as a clinical marker for activity aiding in dose adjustments. The kinetics of formation is not known, however, and must determined order to establish under what conditions can CYP3A marker. STUDY ADDS concentration increases very slowly during CYP3A4/5 induction paediatric patients. Whereas was apparently complete within 1–2 weeks...
Retrospective evaluation of medical history and 3635 anti-TBE (tick-borne encephalitis) serologies during the years 2003-2008 indicates that childhood TBE is characterized by vague symptoms. Clinical findings suggest a nonspecific inflammatory disease with restricted encephalitic profile compared adult TBE. Childhood might elude diagnosis, which unsatisfactory because potential long-term consequences.
Abstract Aim This study evaluated whether maternal mood disorders (MMD), particularly bipolar disorder, and lithium treatment during pregnancy influenced the neonatal health cognition of children born from 2006 to 2010. Methods Our at Karolinska University Hospital, Stockholm, Sweden, focused on women with without their children. Information pharmacotherapy, mental health, delivery complications was retrospectively collected electronic patient records. Children were tested in a blinded...
Abstract Purpose Sertraline, a selective serotonin reuptake inhibitor (SSRI), is one of the most commonly used antidepressant during pregnancy. Plasma sertraline concentrations vary markedly between individuals, partly explained by variability in hepatic drug metabolizing cytochrome P450-enzyme activity. Our purpose was to study plasma pregnant women and passage their infants. Method Pregnant with moderate untreated depression were recruited 2016–2019 Stockholm Region randomized treatment or...
Objective To investigate the admission rate to neonatal care and morbidity after maternal use of antipsychotics during pregnancy. Design A population-based register study. Setting Information on all singleton births between July 2006 December 2017 in Sweden including data prescription drugs, deliveries infants’ health was obtained from Swedish Medical Birth Register, Prescribed Drug Register Neonatal Quality Register. Exposed infants were compared with unexposed mothers treated before or but...
Summary Purpose: In order to evaluate long‐term effects on neurodevelopment in children born women with epilepsy during pregnancy we studied the children’s school grades at age 16. Methods: We used Patient Register, Medical Birth and a local study South Hospital, Stockholm, identify Sweden who had given birth between 1973 1986. The Swedish School Mark Registry was obtain information about from last year of compulsory school, Exposed were compared all other Key Findings: records analyzed for...