A quality control study was made of the Swedish Medical Birth Registry. This registry used one mode data collection during 1973-1981 and another from 1982 onwards. The number errors in register checked by comparing information with a sample original medical records, variability use diagnoses between hospitals studied. Different types were identified quantified efficiency two methods evaluated.

Concerns have been expressed about possible adverse effects of the use antidepressant medication during pregnancy, including risk for neonatal pathology and presence congenital malformations.Data from Swedish Medical Birth Register (MBR) 1 July 1995 up to 2007 were used identify women who reported antidepressants in early pregnancy or prescribed by antenatal care: a total 14 821 with 15 017 infants. Maternal characteristics, maternal delivery diagnoses, infant diagnoses malformations...

Exposure to antidepressants during the third trimester of pregnancy has been associated with an increased risk for adverse birth outcomes, including preterm birth, respiratory distress, and hypoglycemia.To investigate neonatal outcomes in 997 infants (987 mothers) after maternal use based on prospectively recorded information antenatal care documents.An (odds ratio [OR], 1.96) low weight (OR, 1.98) was verified, but gestational week-specific notably exposure tricyclic antidepressants. An a...

Abstract BACKGROUND: Maternal use of selective serotonin re‐uptake inhibitors (SSRIs) has recently been associated with an increased risk for certain malformations. METHODS: Using the Swedish Medical Birth Register, we identified women who had reported SSRIs in early pregnancy and studied their infants, born between July 1, 1995 end 2004. Congenital malformations were from that register, Register Malformations, Hospital Discharge Register. The effect drug exposure was after adjustment a...

Aim : Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) monotherapy. Methods Infants exposed ( n = 1398) early pregnancy were identified from Swedish Medical Birth Registry. number infants with congenital malformations AED compared expected estimated all born 582656). Results 90% (1256) children monotherapy, 56% CBZ 21% VPA. odds...

Abstract BACKGROUND : The objective of this study was to assess, in a large data set from Swedish Medical Health Registries, whether maternal obesity and morbid were associated with an increased risk for various structural birth defects. METHODS population consisted 1,049,582 infants born Sweden January 1, 1995, through December 31, 2007, known weight height data. Women grouped six categories body mass index (BMI) according World Organization classification. Infants congenital defects...

BACKGROUND The possible excess of congenital malformations in infants born after vitro fertilization (IVF) has been much discussed the literature, with controversial conclusions. This population based study is aimed at analyzing presence a large group IVF and to compare malformation risk both that all according method used. METHODS Infants during period 1982–2001 were ascertained from clinics Sweden. was identified three national health registers: Swedish Medical Birth Register, Registry...

Exposure to Benzodiazepines (BZD) during foetal life has been suggested contribute neonatal morbidity and some congenital malformations, for example, orofacial clefts. Here we aimed study the outcome malformations in neonates whose mothers reported use of BZD and/or hypnotic benzodiazepine receptor agonists (HBRA) pregnancy.In Swedish Medical Birth Register identified 1979 infants (n = 1944) HBRA early pregnancy. An additional 401 were studied, born 390 who prescribed such drugs late...

We studied a large data set from three registries of congenital malformations (central-east France, Sweden, and California), total 954 cases, known chromosome anomalies excluded. The prevalence at birth varied significantly between programmes, probably to extent because different ascertainment inclusion criteria, 0.76 per 10,000 births in the French programme 2.35 Swedish. Within California programme, there is racial variability with lower values among whites (and blacks) than Hispanics...

We studied major malformations in 5,581 infants with Down syndrome (DS) from three registers of congenital malformations. THe prevalence at birth 23 different was compared the program-specific rates for each malformation non-DS infants. An about 300 times risk increase seen annular pancreas, cataracts and duodenal atresia an 100 megacolon small choanal atresia. Esophageal, anal bowel atresia, preaxial polydactyly, omphalocele all showed increases between 10 30 times. Statistically...

The effect of various antipsychotics during pregnancy has repeatedly been studied, but for most atypical antipsychotics, only little information is available. We identified from the Swedish Medical Birth Register 2908 women who had reported use any antipsychotic or lithium in early and studied malformation rates with data also Congenital Malformations Hospital Discharge Register. Comparisons were made all births (n = 958,729) after adjustment some confounders. Risks expressed as odds ratios...

Abstract BACKGROUND: Azathioprine (AZA) is used during pregnancy by women with inflammatory bowel disease (IBD), other autoimmune disorders, malignancy, and organ transplantation. Previous studies have demonstrated potential risks. METHODS: The Swedish Medical Birth Register was to identify 476 who reported the use of AZA in early pregnancy. effect exposure on outcomes studied after adjustment for maternal characteristics that could act as confounders. RESULTS: most common indication IBD....

Abstract In order to evaluate the previously published association between maternal use of selective serotonin re‐uptake inhibitors (SSRI) and persistent pulmonary hypertension in neonate (PPHN), we used data from Swedish Medical Birth Register for years 1997–2005. Infants were identified discharge diagnoses, exposure drugs interviews performed early pregnancy prescriptions antenatal care service. Putative confounders studied: an increased risk PPHN was indicated high age, first parity, BMI,...

Abstract BACKGROUND: The risk for congenital malformations is increased in infants born after vitro fertilization (IVF). Some specific appear to be more affected than others. METHODS: presence of 15,570 IVF with an embryo transfer between April 1, 2001, and the end 2006 were compared all Sweden during 2001 2007 (n = 689,157). Risk estimates made adjusting year birth, maternal age, parity, smoking, body mass index. risks data from a previous study (1982 March 31, 2001) 16,280 IVF. Different...

Abstract Objective : This study determined whether obese women have an increased risk of cardiovascular defects in their offspring compared with average weight women. Research Methods and Procedures In a case‐control study, prospectively collected information was obtained from Swedish medical health registers. The included 6801 who had infants defect and, as controls, all delivered ( N = 812, 457) during the period (1992 to 2001). Infants chromosomal anomalies or whose mothers pre‐existing...

A prospective study was performed on the effect of smoking pregnancy, using information from 6 363 pregnancies with known habits. Of these, 2806 (44%) smoked during and 2731 (97%) 2 806 reported that they whole pregnancy. The well‐known prematurity rate mean birth weight verified in this study. 50% increase registered among women compared non‐smoking women. reduction 170 g live‐born, non‐malformed children. These effects were found to occur irrespective other variables studied: maternal age,...