Background Intimate partner violence (IPV) against women is associated with a wide range of adverse outcomes. Although mental disorders have been linked to an increased risk perpetrating IPV women, the direction and magnitude association remain uncertain. In longitudinal design, we examined between perpetrated by men towards in population-based sample used sibling comparisons control for factors shared siblings, such as genetic early family environmental factors. Methods findings Using...

Abstract Objective To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, both road traffic incidents offences), mental health (suicidal behaviour, unintentional overdoses), criminality. Design Population based cohort study. Setting High quality prescription, patient, death, crime registers, Sweden. Participants 191 973 people from the Swedish Prescribed Drug Register who collected prescriptions for (pregabalin...

<h3>Importance</h3> Individuals who self-harm may have an increased risk of aggression toward others, but this association has been insufficiently investigated. More conclusive evidence affect assessment, treatment interventions, and clinical guidelines. <h3>Objective</h3> To investigate the between nonfatal violent crime. <h3>Design, Setting, Participants</h3> This population-based longitudinal cohort study, conducted from January 1, 1997, through December 31, 2013, studied all Swedish...

Background Pharmacoepidemiological studies have long raised concerns on widespread use of benzodiazepines and benzodiazepine-related drugs (BZDs), in particular long-term use, among adults the elderly. In contrast, evidence pertaining to rates BZD at younger ages is still scarce, factors that influence utilisation shape different prescribing patterns youths remain largely unexplored. We examined prevalence rates, relative changes over time, for dispensation young people aged 0–24 years...

Background Although selective serotonin reuptake inhibitors (SSRIs) are widely prescribed, associations with violence uncertain. Methods and Findings From Swedish national registers we extracted information on 856,493 individuals who were prescribed SSRIs, subsequent violent crimes during 2006 through 2009. We used stratified Cox regression analyses to compare the rate of crime while these medications in same not receiving medication. Adjustments made for other psychotropic medications....

Objective To examine the association between different levels of childhood attention deficit hyperactivity disorder ( ADHD ) symptoms and sex differences in psychosocial outcomes during adolescence. Method Swedish children n = 4635) were screened for neuropsychiatric at age 9 or 12. divided into three levels: screen‐negative, screen‐intermediate, screen‐positive. At follow‐up (age 15), parents teenagers filled out questionnaires regarding (i) hyperactivity/inattention, (ii) peer problems,...

Objective: The authors examined associations between medications for alcohol and opioid use disorders (acamprosate, naltrexone, methadone, buprenorphine) suicidal behavior, accidental overdoses, crime. Method: In this total population cohort study, 21,281 individuals who received treatment with at least one of the four 2005 2013 were identified. Data on medication outcomes collected from Swedish population-based registers. A within-individual design (using stratified Cox proportional hazards...

<b>Objective</b> To examine associations between varenicline and the incidence of a range adverse outcomes. <b>Design</b> Population based cohort study using within person analyses to control for confounding by indication. <b>Setting</b> Whole population Sweden. <b>Participants</b> 7 917 436 people aged 15 over, whom 69 757 were treated with 2006 2009. <b>Main outcome measures</b> Incidence new psychiatric conditions, suicidal behaviour, suspected convicted criminal offending, transport...

Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible between statins suicidality, depression, anxiety, seizures.Using Swedish national registers, we linked data on dispensed statin prescriptions unplanned (emergency) hospital visits or specialised outpatient care for four outcomes: suicidal behaviour (including deaths from suicide), depressive disorders, anxiety seizures. included all individuals in registries who were...

Introduction Type 2 diabetes is a risk factor for dementia and Parkinson’s disease (PD). Drug treatments diabetes, such as metformin, could be used novel these neurological conditions. Using electronic health records from the USA (OPTUM EHR) we aimed to assess association of metformin with all-cause dementia, subtypes PD compared sulfonylureas. Research design methods A new user comparator study was conducted in patients ≥50 years old who were users or sulfonylureas between 2006 2018....

This study examines trends in antidepressant drug dispensations among young people aged 0-24 years Sweden during the period 2006-2013, as well prescription patterns and central nervous system (CNS) polypharmacy with antidepressants. Using linkage of Swedish national registers, we identified all residents that collected at least one (here defined users) between 1 January 2006 31 December 2013 (n = 174,237), categorized them children (0-11 years), adolescents (12-17 adults (18-24 years)....

Background β-blockers are widely used for treating cardiac conditions and suggested the treatment of anxiety aggression, although research is conflicting limited by methodological problems. In addition, have been associated with precipitating other psychiatric disorders suicidal behaviour, but findings mixed. We aimed to examine associations between behavioural outcomes in a large population-based cohort Sweden. Methods conducted longitudinal study using Swedish nationwide high-quality...

Background Assessment of suicide risk in individuals who have self-harmed is common emergency departments, but often based on tools developed for other purposes. Objective We and validated a predictive model following self-harm. Methods used data from Swedish population-based registers. A cohort 53 172 aged 10+ years, with healthcare episodes self-harm, was split into development (37 523 individuals, whom 391 died within 12 months) validation (15 649 178 suicides samples. fitted...

Background. Antisocial behavior is a known risk factor for substance use in adolescence, but the combined effects of antisocial and prosocial behaviors are unknown. This study examined whether five types anti- associated with subsequent alcohol use.Methods. A prospective longitudinal cohort 3817 adolescents (55.3% females) aged 15 at baseline (T1) 17 follow-up (T2). Self-reports T1 measured (criminal behavior, conduct problems) (global prosociality, general trust, institutional trust). T2...

Antisocial behavior is a known risk factor for substance use in adolescence, but the combined effects of antisocial and prosocial behaviors are unknown. This study examined whether five types anti- associated with subsequent alcohol use. A prospective longitudinal cohort 3817 adolescents (55.3% females) aged 15 at baseline (T1) 17 follow-up (T2). Self-reports T1 measured (criminal behavior, conduct problems) (global prosociality, general trust, institutional trust). T2 measures included...

Objective: To compare outcomes over 30 years experienced by individuals who as adolescents entered substance misuse treatment and a general population sample. Method: All 1992 seen at the only clinic for misusing in Stockholm from 1968 to 1971 were compared randomly selected Swedish population, matched sex, age birthplace. Death, hospitalization physical illness related misuse, mental illness, criminal convictions poverty documented national registers. Results: Relative risks of death,...

The adenosine A 2A receptor ( ADORA2A ) is linked to the dopamine neurotransmitter system and also implicated in regulation of alertness, suggesting a potential association with attention‐deficit hyperactivity disorder ADHD traits. Furthermore, animal studies suggest that may influence ‐like behavior. For reason, gene emerges as promising candidate for studying etiology aim this study was examine relationship between polymorphisms traits large population‐based sample. This based on Child...

Abstract Background Gaming is a popular past‐time activity among children and adolescents, but it there also possible link to negative consequences such as psychological distress lowered academic achievement. However, are fundamental knowledge gaps remaining regarding central characteristics of gaming heritability, stability over time, sex differences. We examined the genetic environmental contribution behavior, including differences, continuity change, in longitudinal cohort twins. Methods...

The impact of traumatic brain injury (TBI) on subsequent risk schizophrenia (SCZ) or bipolar disorder (BD) remains contested. Possible genetic and environmental confounding effects have also been understudied. Therefore, we aim to investigate the TBI SCZ BD whether effect varies by severity, age at injury, sex. We identified 4,184 18,681 cases born between 1973 1998 in Swedish National Registers. Case-control samples matched (1:5) birth year, sex, birthplace were created along with a family...

The study examined associations between antisocial behavior (ASB) before age 15 and eight adverse outcomes from 21 to 50 among 1,623 men 324 women who as adolescents consulted a clinic for substance misuse problems. Outcomes were documented using Swedish national registers included death, hospitalization physical illnesses related misuse, mental illness, self-inflicted harm, convictions violent nonviolent crimes, poverty. ASB was associated with increased odds of all in adulthood except...

This study identified individuals ever dispensed a selective serotonin reuptake inhibitor (SSRI) aged 15–60 years during 2006–2013, using Swedish national registers. The outcome was violent crime conviction. main statistical analyses assessed risks of periods on compared to off SSRI treatment within individuals. Further investigated risk over time in relation initiation and discontinuation. 785,337 (64.2% female), experiencing 32,203 crimes 5,707,293 person-years. Between-individual found...

The use of anabolic-androgenic steroids has increased among gym-goers, and it been proposed that this may be part a polysubstance pattern includes the illicit drugs. Still, epidemiological data on drug gym-goers both genders are meager. aim present study was thus to examine drugs its correlates in large sample men women who engaged weight training at gyms across Sweden. In cross-sectional study, total 1969 54 Sweden were invited fill questionnaire. questionnaire included 25 items background...

Objective Neurodevelopmental problems (NDPs) may influence the transition from childhood to adolescence. Our aim was study long-term psychosocial outcomes of NDPs, focusing on ADHD. Method Data collected through a telephone interview with parents twins at ages 9 or 12 years. NDP screen-positive children were clinically assessed age 15; N = 450. Psychosocial outcome concerning peers, school, internalizing problems, antisocial behavior, alcohol misuse, drug and impaired daily functioning...