A5033402107- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Adolescent and Pediatric Healthcare
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Child and Adolescent Health
- Childhood Cancer Survivors' Quality of Life
- Genetic Associations and Epidemiology
- Child and Adolescent Psychosocial and Emotional Development
- Schizophrenia research and treatment
- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- BRCA gene mutations in cancer
- Natural Antidiabetic Agents Studies
- Health disparities and outcomes
- Chromosomal and Genetic Variations
- Autopsy Techniques and Outcomes
- Diet, Metabolism, and Disease
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Epilepsy research and treatment
- Research in Social Sciences
- Pregnancy and preeclampsia studies
- Pharmacology and Obesity Treatment
Karolinska Institutet
2021-2024
Newcastle University
2017-2022
Newcastle Hospitals - Campus for Ageing and Vitality
2021
Abstract Background and Hypothesis Schizophrenia (SCZ) bipolar disorder (BD) have shared genetic risk clinical symptoms, yet the extent to which environmental factors are is not well known. We aimed examine associations of early-life exposures with SCZ BD. Study Design conducted a Swedish register-based nested case–control study using 4184 18 681 BD cases diagnosed 1988–2013, individually matched 5 population-based controls by birth year, sex birthplace. Conditional logistic regression was...
Shared genetic risk between schizophrenia (SCZ) and bipolar disorder (BD) is well-established, yet the extent to which they share environmental factors remains unclear. We compare associations exposures during childhood/prior onset with of developing SCZ BD.
The impact of traumatic brain injury (TBI) on subsequent risk schizophrenia (SCZ) or bipolar disorder (BD) remains contested. Possible genetic and environmental confounding effects have also been understudied. Therefore, we aim to investigate the TBI SCZ BD whether effect varies by severity, age at injury, sex. We identified 4,184 18,681 cases born between 1973 1998 in Swedish National Registers. Case-control samples matched (1:5) birth year, sex, birthplace were created along with a family...
Abstract Background High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised linking life exposures and subsequent disease. However, epigenetic changes high have not previously investigated. Our aim was to investigate associations between gain, peripheral blood methylation, overweight/obese. Data from UK Avon Longitudinal study of Parents Children (ALSPAC) cohort were used estimate epigenome-wide...
Abstract Background Childhood cancer survivors (CCS) exhibit significantly increased chronic diseases and premature death. Abnormalities in DNA methylation are associated with development of reduced life expectancy. We investigated the hypothesis that anti-cancer treatments long-term changes could be key drivers adverse late health effects. Methods Genome-wide was assessed using MethylationEPIC arrays paired samples (before/after therapy) from 32 childhood patients. Separately, determined...
The identification of early markers dementia is important for higher-risk populations such as those with type 2 diabetes (T2D). Retrotransposons, including long interspersed nuclear element 1 (LINE-1) and Alu, comprise ~40% the human genome. Although dysregulation these retrotransposons can induce aberrant gene regulation genomic instability, their role in development pre-symptomatic (PSD) among T2D patients unknown. Here, we examined locus-specific changes LINE-1 Alu methylation PSD...
Prior studies report increased risk of schizophrenia (SCZ) in migrants relative to the native-born population; however, few have investigated bipolar disorder (BD) and migrant characteristics which may influence risk. We aimed examine SCZ BD their children those Swedish ancestry, whether varied by age at migration, region origin, sex, parental status.
Persistent DNA methylation changes may mediate effects of early-life exposures on later-life health. Human lifespan is challenging for prospective studies, therefore data from longitudinal studies are limited. Projecting mouse models exposure to human offers a tool address this challenge.C57BL/6J mice were fed low/normal folate diets before and during pregnancy lactation. Genome-wide promoter was measured in male offspring livers at 17.5 days gestation 28 weeks. Eight promoters concurrently...
It is well established that both genetic and environmental factors contribute to risk for schizophrenia (SCZ), much progress has been made in identifying the specific conferring risk. However, nature extent of interactions between them long a topic debate. Both data methods available address this have evolved rapidly, enabling new prospects gene–environment SCZ. To date, there limited evidence strong interactions, with factors, molecular risk, family history simultaneously contributing...
Searchable abstracts of presentations at key conferences in obesity ISSN 2632-9808 (online)