A5086741151- Effects and risks of endocrine disrupting chemicals
- Potato Plant Research
- Toxic Organic Pollutants Impact
- Fungal and yeast genetics research
- Photochromic and Fluorescence Chemistry
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Pharmaceutical studies and practices
- Statistical Methods and Inference
- Plant Pathogens and Resistance
- Animal testing and alternatives
- Statistical Methods and Bayesian Inference
- Environmental Justice and Health Disparities
- Health, Environment, Cognitive Aging
- Data Quality and Management
- Data Analysis with R
- Mental Health Research Topics
- Agricultural safety and regulations
- Garlic and Onion Studies
- Per- and polyfluoroalkyl substances research
- Time Series Analysis and Forecasting
- Evolution and Genetic Dynamics
- Cardiac electrophysiology and arrhythmias
- Nicotinic Acetylcholine Receptors Study
German Environment Agency
2022-2024
Amazon (Germany)
2019
Vrije Universiteit Amsterdam
2018-2019
Google (United States)
2017
East Tennessee State University
1998
Abstract Fluorescent proteins (FPs) are widely used in many organisms, but commonly characterised vitro . However, the properties may poorly reflect vivo performance. Therefore, we 27 FPs using Saccharomyces cerevisiae as model organism. We linked via a T2A peptide to control FP, producing equimolar expression of 2 from 1 plasmid. Using this strategy, for brightness, photostability, photochromicity and pH-sensitivity, achieving comprehensive characterisation. Many showed different compared...
Phthalates and the substitute plasticizer DINCH belong to first group of priority substances investigated by European Human Biomonitoring Initiative (HBM4EU) answer policy-relevant questions safeguard an efficient science-to-policy transfer results. internal exposure levels were assessed using two data sets from all regions Israel. The collated existing human biomonitoring (HBM) (2005-2019). second consisted new generated in harmonized "HBM4EU Aligned Studies" (2014-2021) on children...
Human biomonitoring (HBM) data in Europe are often fragmented and collected different EU countries sampling periods. Exposure levels for children adult women were evaluated over time. For the period 2000–2010, literature aggregated a harmonized way across studies. Between 2011–2012, biobanked samples from DEMOCOPHES project used. 2014–2021, HBM generated within HBM4EU Aligned Studies. Time patterns on internal exposure visually statistically using 50th 90th percentiles (P50/P90)...
Modern companies and institutions rely on data to guide every single decision. Missing or incorrect information seriously compromises any decision process. We demonstrate "Deequ", an Apache Spark-based library for automating the verification of quality at scale. This provides a declarative API, which combines common constraints with user-defined validation code, thereby enables "unit tests data". Deequ is available as open source, meets requirements production use cases Amazon, scales...
Human health risk assessment of chemical mixtures is complex due to the almost infinite number possible combinations chemicals which people are exposed on a daily basis. biomonitoring (HBM) approaches can provide inter alia information that in our body at one point time. Network analysis applied such data may insight into real-life by visualizing exposure patterns. The identification groups more densely correlated biomarkers, so-called “communities”, within these networks highlights...
Phthalates are mainly used as plasticizers and associated inter alia with adverse effects on reproductive functions. While more national programs in Europe have started monitoring internal exposure to phthalates its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across is challenging. They differ widely time periods, study samples, degree geographical coverage, design, analytical methodology, biomarker...
Chemical mixture risk assessment has, in the past, primarily focused on exposures quantified external environment. Assessing health risks using human biomonitoring (HBM) data provides information internal concentration, from which a dose can be derived, of chemicals to populations are exposed. This study describes proof concept for conducting with HBM data, population-representative German Environmental Survey (GerES) V as case study. We first attempted identify groups correlated biomarkers...
Abstract Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed AA exposure, measured by urinary mercapturic acids (AAMA) and glycidamide (GAMA), its main metabolite, 3157 children/adolescents 1297 adults the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data quality assured measurements AAMA GAMA (urine collection: 2014–2021), short-term validated biomarkers were obtained from four...
Acrylamide, a substance potentially carcinogenic in humans, represents very prevalent contaminant food and is also contained tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown induce neurotoxicity humans. To minimize related risks for public health, it vital obtain data on the actual level differently affected segments population. achieve this aim, has been added list substances concern be investigated HBM4EU project, European initiative biomonitoring...
Abstract Fluorescent proteins (FPs) are widely used in many organisms, but commonly characterised vitro. However, the vitro properties may poorly reflect vivo performance. Therefore, we 27 FPs using Saccharomyces cerevisiae as model organism. We linked via a T2A peptide to control FP, producing equimolar expression of 2 from 1 plasmid. Using this strategy, for brightness, photostability, photochromicity and pH-sensitivity, achieving comprehensive characterisation. Many showed different...
Background: Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed AA exposure, measured by urinary biomarkers, mercapturic acids (AAMA) and glycidamide (GAMA), 3,157 children/adolescents 1,297 adults from studies participating the European Human Biomonitoring Initiative HBM4EU.Material Methods: Harmonized individual-level questionnaire data quality assured measurements AAMA GAMA levels urine (collected between...
Background: Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed AA exposure, measured by urinary biomarkers, mercapturic acids (AAMA) and glycidamide (GAMA), 3,157 children/adolescents 1,297 adults from studies participating the European Human Biomonitoring Initiative HBM4EU.Material Methods: Harmonized individual-level questionnaire data quality assured measurements AAMA GAMA levels urine (collected between...