A5076396818- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Indoor Air Quality and Microbial Exposure
- Occupational exposure and asthma
- Hormonal and reproductive studies
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Mycotoxins in Agriculture and Food
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Microplastics and Plastic Pollution
- Chromium effects and bioremediation
- Atmospheric Ozone and Climate
- Adipose Tissue and Metabolism
- Agriculture Sustainability and Environmental Impact
- Spectroscopy and Laser Applications
- Chemical Safety and Risk Management
- Mass Spectrometry Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Quality and Safety in Healthcare
- Stress Responses and Cortisol
- Safe Handling of Antineoplastic Drugs
- Occupational and environmental lung diseases
Institut National de Recherche et de Sécurité
2010-2021
Université de Reims Champagne-Ardenne
2021
Zimmer Biomet (France)
2019-2020
Stress Environnementaux et Biosurveillance des Milieux Aquatiques
2010
Centre National de la Recherche Scientifique
1976-2009
Center of Immunology Pierre Fabre
2009
Université de Strasbourg
2009
Clermont Université
1976-1984
Technicolor (France)
1969
The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure relevant priority chemicals developing new approaches for biomonitoring. In this manuscript, hexavalent chromium [Cr(VI)] study design presented as first example of HBM4EU approach. This involves eight European countries plans recruit 400 workers performing Cr(VI) surface treatment e.g....
Monoclonal antibodies (mAbs) have taken on an increasing importance for the treatment of various diseases including cancers, immunological disorders, and other pathologies. These large biomolecules display specific structural features, which affect their efficiency need, therefore, to be extensively characterized using sensitive orthogonal analytical techniques. Among them, mass spectrometry (MS) has become method choice study mAb amino acid sequences as well post-translational...
As an essential component of polycarbonate plastics and epoxy resins, Bisphenol A (BPA) is found in numerous industrial consumer products. BPA may cause adverse health effects because its endocrine activity. General population exposure to this compound mainly through diet well documented. Thermal paper was also identified as a source dermal intake. In study, we investigated whether frequent contact with thermal associated increase urinary excretion. We evaluated the cashiers...
Summary. Testosterone and androstenedione concentrations in the plasma testis of male guinea-pigs were estimated by gas chromatography at intervals (36 stages) from birth to death. Four main periods androgenic activity recognized. The neonatal period, Day 16, is characterized a precocious but transient peak testosterone concentration Days 2 3. pubertal period 16 90 can be subdivided into prepubertal starting on marked sudden linear increase testicular together with an seminal vesicle weight,...
In utero exposure to the phthalate ester plasticizer di-n-hexyl (DnHP) is known affect development of male reproductive system and induce alterations in androgen-dependent tissues rat offspring. Male malformations produced by several phthalates have been causally linked decreased testosterone production during gestational period. This study was designed evaluate dose-response relationship for effects DnHP on synthesis fetal testis. Pregnant Sprague-Dawley rats were administered vehicle...
Investigating workplace exposure to mycotoxins is of the utmost importance in supporting implementation preventive measures for workers. The aim this study was provide tools measuring urine and airborne samples. A multi-class mycotoxin method developed determination aflatoxin B1, M1, ochratoxin A, α, deoxynivalenol, zearalenone, α-zearalenol, β-zearalenol, fumonisin HT2-toxin T2-toxin. Analysis based on liquid chromatography–high resolution mass spectrometry. Sample pre-treatments included...
Objective The objective of the study was to examine effects occupational exposure diisononyl phthalate (DINP) on serum testosterone levels in male workers. Methods From 2015 2018, 97 workers were recruited from six French factories plastics industry. In a short longitudinal study, changes over 3 days level total or free and DINP measured. measured by urinary biomonitoring: mono-4-methyl-7-oxo-octyl (OXO-MINP), mono-4-methyl-7-hydroxy-octyl (OH-MINP) mono-4-methyl-7-carboxyheptylphthalate...
Background Exposure to aerosols from metalworking fluids (MWF) has previously been related a series of adverse health outcomes (eg, cancer, respiratory diseases). Our present epidemiological study focuses on occupational exposures MWF and panel exposure effect biomarkers. We hypothesize that these are caused by particle generates oxidative stress, leading airway inflammation ultimately chronic diseases. aimed assess whether exposure, in particular as characterized its potential, is...
Pregnant Sprague–Dawley rats were administered deltamethrin, at doses 0.1, 1, 5 or 10 mg kg−1 day−1, di-n-hexyl phthalate (DnHP) (250 day−1), by gavage, from gestational day 13 to 19. Maternal toxicity was observed as evidenced transient clinical signs of neurotoxicity and reductions in body weight, weight gain corrected gain. Deltamethrin had no statistically significant effect on the incidence post-implantation loss, fetal anogenital distance male fetuses. Unlike DnHP, deltamethrin induced...
Abstract Objectives Electroplating processes are widely used in metal industries to improve the resistance properties of manufactured parts. Workers this industry potentially exposed both hexavalent chromium (Cr(VI)) and other compounds [mostly trivalent (Cr(III))], due use chromic acid baths. The goal study was validate urinary as a Cr(VI) exposure biomarker presence compounds. Methods A biomonitoring consisted monitoring airborne for one working week 93 workers from nine electroplating...
It is now recognized that additional exposure to mycotoxins may occur through inhalation of contaminated dust at a workplace. The aim this study was characterize the multi-mycotoxin French grain elevator workers using biomonitoring and airborne measurements. Eighteen participated in study. Personal samples were analyzed for their mycotoxin concentrations. Workers provided multiple urine including pre-shift, post-shift first morning or 24 h samples. Mycotoxin urinary biomarkers (aflatoxin B1,...