A5084859047- Metabolomics and Mass Spectrometry Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Per- and polyfluoroalkyl substances research
- Diet and metabolism studies
- Toxic Organic Pollutants Impact
- Fish Ecology and Management Studies
- Zebrafish Biomedical Research Applications
- Air Quality and Health Impacts
- Microplastics and Plastic Pollution
- Health, Environment, Cognitive Aging
- Advanced Chemical Sensor Technologies
- Gut microbiota and health
- Effects and risks of endocrine disrupting chemicals
- Nutritional Studies and Diet
- Birth, Development, and Health
- Reproductive biology and impacts on aquatic species
- Pharmaceutical studies and practices
- Phytochemistry and Bioactivity Studies
- Pesticide Residue Analysis and Safety
- Pharmacological Effects and Toxicity Studies
- Analytical Chemistry and Chromatography
- Molecular Biology Techniques and Applications
- Insect and Arachnid Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
Chalmers University of Technology
2021-2024
Stockholm University
2015-2022
San Antonio College
2019
Uppsala University
2014
The potential of a metabolomics method to detect statistically significant perturbations in the metabolome an organism is enhanced by excellent analytical precision, unequivocal identification, and broad metabolomic coverage. While former two metrics are usually associated with targeted latter non-targeted metabolomics, systematic comparison performance both approaches has not yet been carried out. present work reports on development evaluation separate methods. approach facilitated...
The quantity and composition of fibers released from functional textiles during accelerated washing were investigated using the GyroWash method. Two fabrics [polyamide (PA) polyester/cotton (PES/CO)] selected coated with perfluorohexane-based side-chain fluorinated polymers. Fibers ranged ∼10 to 500 μ a similar distribution for two textile types. PA-based fabric considerably more >20 μm in length compared PES/CO-based (>1000/GyroWash PA vs ∼200/GyroWash PES/CO). After one (2-15 domestic...
Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) stroke the Swedish Mammography Cohort – Clinical (n = 657 subjects). OCs, PFAS, multiomics (9511 liquid...
Methylmercury (MeHg) and perfluorooctanesulfonate (PFOS) are major contaminants of human blood that both common in dietary fish, thereby raising questions about their combined impact on development. Here, pregnant Sprague-Dawley rats ingested a daily dose, from gestational day 1 through to weaning, either mg/kg bw PFOS (PFOS-only), MeHg (MeHg-only), mixture 0.1 (Low-Mix), or (High-Mix). Newborns were monitored for physical milestones reflexive developmental responses, juveniles the...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, but if discovered at an early stage, the survival rate high. The aim this study was to identify novel markers predictive future CRC risk using untargeted metabolomics.
We investigated data-driven and hypothesis-driven dietary patterns their association to plasma metabolite profiles subsequent colorectal cancer (CRC) risk in 680 CRC cases individually matched controls. Dietary were identified from combined exploratory/confirmatory factor analysis. assessed LC-MS metabolic by random forest regression multivariable conditional logistic regression. Principal component analysis was used on features selected reflect exposures. Component scores associated...
The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle living environments. These correspond to changes our "modern" postwar societies globally characterized by rural-to-urban migration, modernization agricultural practices, transportation, climate change, aging. Evidence suggests that these are related each other, although the social biological mechanisms as well their interactions yet be uncovered....
Diet is considered a culprit for symptoms in irritable bowel syndrome (IBS), although the mechanistic understanding of underlying causes lacking. Metabolomics, i.e., analysis metabolites biological samples may offer diet-responsive fingerprint IBS. Our aim was to explore alterations plasma metabolome after interventions with fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) or gluten versus control IBS, relate such symptoms. People IBS (n = 110) were...
Ecotoxicity testing is a crucial component of chemical risk assessment. Still, due to methodological difficulties related controlling exposure concentrations over time, data on long-term effects organic chemicals at low are limited. The aim the present study was, therefore, test applicability passive dosing maintain stable organochlorine bacteriocide triclosan in water phase during 6-wk multigeneration population development with harpacticoid copepod Nitocra spinipes. Triclosan was loaded...
Bioconcentration factors (BCFs) in rainbow trout were measured for 10 anionic surfactants with a range of alkyl chain lengths and different polar head groups. The BCFs ranged from 0.04 L kg–1 ww (for C10SO3) to 1370 (C16SO3). There was strong correlation between the log BCF membrane lipid–water distribution ratio (DMLW, r2 = 0.96), biotransformation identified as dominant elimination mechanism. positive influence DMLW on attributed two phenomena: (i) increased partitioning water into...
The antidepressant amitriptyline is a widely used selective serotonin reuptake inhibitor that found in the aquatic environment. present study investigates alterations brain and liver metabolome of gilt-head bream (Sparus aurata) after exposure at an environmentally relevant concentration (0.2 µg/L) for 7 d. Analysis variance-simultaneous component analysis to identify metabolites distinguish exposed from control animals. Overall, lipid metabolism suggest occurrence oxidative stress both...
The present work assesses the exposure of a child cohort to PFOA, PFOS and PFHxS from 1 year 10.5 years age.
Toxicometabolomics and biotransformation product (bioTP) elucidation were carried out in single zebrafish (ZF) embryos exposed to carbamazepine (CBZ). Exposures conducted 96-well plates containing six CBZ concentrations ranging from 0.5 μg/L 50 mg/L (
A high-throughput toxicometabolomic assay involving single zebrafish embryos was developed which links apical endpoints to biochemical perturbations.
Host-microbiome interactions are essential for the physiological and ecological performance of host, yet these challenging to identify. Neurotransmitters commonly implicated in interactions, but we know very little about mechanisms their involvement, especially invertebrates. Here, report a peripheral catecholamine (CA) pathway involving gut microbiome model species Daphnia magna. We demonstrate following: (i) tyrosine hydroxylase Dopa (3,4-dihydroxyphenylalanine) decarboxylase enzymes...
A procedure was developed for rapid screening of xenobiotic biotransformation products (bioTPs) in single zebrafish (ZF; Danio rerio) embryos. Exposure carried out from 0-120 hours post fertilization (hpf) to 6 different concentrations the model compound propranolol (PPL). Following in-plate extraction and non-target instrumental analysis by high resolution mass spectrometry, suspected bioTPs were identified using custom data filtration scripts matching silico structural predictions. total...
Background/Aim: Prospective birth cohort studies are powerful means of investigating associations between environmental chemical mixtures and neurodevelopmental outcomes in children, but there few developmental toxicity animal models with environmentally relevant mixtures. We investigated the methylmercury (MeHg), presence an organic contaminant, perfluorooctane sulfonate (PFOS). These chemicals two most ubiquitous contaminants dietary fish, little information is available on their...
Single embryos were exposed to the beta blocker propranolol for 120 hpf in 96 well plates, during which apical endpoints determined through microscopy. The water was then removed and analyzed its exposure concentration frozen on dry ice. extracted within plates injected directly from using three different LC-MS methods: Flow-injection lipidomics, C18-Orbitrap HILIC-Orbitrap. Reproducibility evaluated non-exposed four incubated a year later than first plate.
Single embryos were exposed to the beta blocker propranolol for 120 hpf in 96 well plates, during which apical endpoints determined through microscopy. The water was then removed and analyzed its exposure concentration frozen on dry ice. extracted within plates injected directly from using three different LC-MS methods: Flow-injection lipidomics, C18-Orbitrap HILIC-Orbitrap. Reproducibility evaluated non-exposed four incubated a year later than first plate.
Abstract The host-microbiome interactions are essential for the physiological and ecological performance of host, yet these challenging to identify. Neurotransmitters commonly implicated in interactions, but we know very little about mechanisms their involvement, especially invertebrates. Here, report a peripheral Catecholamine (CA) pathway involving gut microbiome model species Daphnia magna . We demonstrate that: (1) tyrosine hydroxylase dopa decarboxylase enzymes present wall; (2) DOPA...