A5039326175- Diet and metabolism studies
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Cancer Treatment and Pharmacology
- Advanced Glycation End Products research
- Telomeres, Telomerase, and Senescence
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Tuberculosis Research and Epidemiology
- Cardiovascular Disease and Adiposity
- Obesity, Physical Activity, Diet
- Microtubule and mitosis dynamics
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Risk Factors
- Mycobacterium research and diagnosis
Instituto de Salud Carlos III
2016-2025
University of Córdoba
2016-2025
Centro de Investigación Biomédica en Red
2015-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2016-2025
Hospital Universitario Reina Sofía
2015-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015-2024
Cordoba University
2021-2024
Sofia University
2021
Menéndez Pelayo International University
2021
Institute for Atherosclerosis Research
2018-2021
Intestinal microbiota changes are associated with the development of obesity. However, studies in humans have generated conflicting results due to high inter-individual heterogeneity terms diet, age, and hormonal factors, largely unexplored influence gender. In this work, we aimed identify differential gut signatures obesity, as a function gender body mass index (BMI). Differences bacterial community structure were analyzed by 16S sequencing 39 men 36 post-menopausal women, who had similar...
Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after specific diet.The aim was to study changes microbiota 1 year's consumption of Mediterranean diet (Med diet) or low-fat, high-complex carbohydrate (LFHCC an obese population.Participants were randomized receive Med (35% fat, 22% monounsaturated) and LFHCC (28% 12% monounsaturated).The conducted 20 patients (men) within Coronary Diet Intervention...
Saturated fatty acid (SFA) high-fat diets (HFDs) enhance interleukin (IL)-1β–mediated adipose inflammation and insulin resistance. However, the mechanisms by which different acids regulate IL-1β subsequent effects on tissue biology sensitivity in vivo remain elusive. We hypothesized that replacement of SFA for monounsaturated (MUFA) HFDs would reduce pro-IL-1β priming attenuate resistance via MUFA-driven AMPK activation. MUFA-HFD–fed mice displayed improved coincident with reduced priming,...
Scope Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences MetS patients are explored according to gender, whether consuming two healthy diets, Mediterranean (MED) low‐fat (LF), may, over time, differentially shape the dysbiosis gender evaluated. Materials Methods All from CORDIOPREV study whose feces samples were available similar number men, matched by main variables ( N = 246, 123...
The consumption of two healthy diets (Mediterranean (MED) and low-fat (LF) diets) may restore the gut microbiome dysbiosis in obese patients depending on degree metabolic dysfunction.The differences bacterial community at baseline after 2 years dietary intervention 106 subjects from CORDIOPREV study were analyzed, 33 whom with severe disease (5 criteria for syndrome) (MetS-OB), 32 without dysfunction (2 or less (NonMetS-OB) 41 non-obese (NonMetS-NonOB). Our showed a marked people (Met-OB),...
We aimed to explore whether changes in circulating levels of miRNAs according type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers evaluate the risk developing disease. The study included 462 patients without T2DM at baseline from CORDIOPREV trial. After a median follow-up 60 months, 107 subjects developed T2DM, 30 prediabetes, 223 maintained and 78 remained disease-free. Plasma four related insulin signaling beta-cell function were measured by RT-PCR. analyzed...
Circulating microRNAs (miRNAs) have been proposed as type 2 diabetes biomarkers, and they may be a more sensitive way to predict development of the disease than currently used tools. Our aim was identify whether circulating miRNAs, added clinical biochemical markers, yielded better potential for predicting diabetes. The study included 462 non-diabetic patients at baseline in CORDIOPREV study. After median follow-up 60 months, 107 them developed Plasma levels 24 miRNAs were measured by...
Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients. Objective: To compare the administration or not of oral calcifediol on mortality risk patients hospitalized because COVID-19. Design: Retrospective, multicenter, open, non-randomized cohort study. Settings: Hospitalized care. Patients: Patients with laboratory-confirmed between 5 February and May 2020 in five hospitals South Spain. Intervention: received (25-hydroxyvitamin D3) (0.266 mg/capsule, 2 capsules...
Background and Purpose: Lifestyle diet affect cardiovascular risk, although there is currently no consensus about the best dietary model for secondary prevention of disease. The CORDIOPREV study (Coronary Diet Intervention With Olive Oil Cardiovascular Prevention) an ongoing prospective, randomized, single-blind, controlled trial in 1002 coronary heart disease patients, whose primary objective to compare effect 2 healthy patterns (low-fat rich complex carbohydrates versus Mediterranean extra...
Type 2 diabetes mellitus (T2DM) is currently a major global public health problem. Although disease remission possible, few biomarkers have been identified which can help us select the diet that best promotes remission. Our aim was to study potential of miRNAs as tool apply Mediterranean or low-fat in order achieve T2DM patients with coronary heart disease. From CORDIOPREV (n = 1002), prospective, randomized, single-blind, controlled dietary intervention trial, all newly diagnosed 190) at...
Circulating microRNAs (miRNAs) have been proposed as biomarkers for type 2 diabetes (T2D). Adipose tissue (AT), which dysfunction is widely associated with T2D development, has reported a major source of circulating miRNAs. However, the role dysfunctional AT in altered pattern miRNAs onset remains unexplored. Herein, we investigated relationship between T2D-associated and function, well preadipocytes adipocytes secreting cells candidate Among plasma related to CORonary Diet Intervention...
Aerogenous infection of C57Bl/6 mice with a virulent strain Mycobacterium tuberculosis (CL 511) leads to the formation primary granulomas in lung where neutrophils, macrophages and subsequently, lymphocytes accumulate progressively around an initial cluster infected macrophages. The spread through parenchyma gives rise secondary featuring numerous that surround small number Afterwards, foamy add outer layer granulomas, which characteristically respect pulmonary interstitium remain confined...
Genetic variation at the Circadian Locomotor Output Cycles Kaput (CLOCK) locus has been associated with lifestyle-related conditions such as obesity, metabolic syndrome (MetS) and cardiovascular diseases. In fact, it suggested that disruption of circadian system may play a causal role in manifestations MetS. The aim this research was to find out whether habitual consumption low-fat diet, compared Mediterranean diet enriched olive oil, modulates associations between common CLOCK single...