A5103185925- Exercise and Physiological Responses
- Plant biochemistry and biosynthesis
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Adipose Tissue and Metabolism
- Research on Leishmaniasis Studies
- Plant Parasitism and Resistance
- Adipokines, Inflammation, and Metabolic Diseases
- Plant Molecular Biology Research
- Virology and Viral Diseases
- Muscle metabolism and nutrition
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Peptides and Activities
- Computational Drug Discovery Methods
- Genetic Associations and Epidemiology
- Light effects on plants
- Rabies epidemiology and control
- Studies on Chitinases and Chitosanases
- Venomous Animal Envenomation and Studies
- Nutrition and Health in Aging
- Influenza Virus Research Studies
- Occupational Health and Performance
- Protein Structure and Dynamics
Instituto Butantan
2023-2025
Universidade Federal de Sergipe
2025
Universidade Federal de Juiz de Fora
2013-2024
Universidade de Brasília
2012-2018
Hospital Universitário - Universidade Federal de Juiz de Fora
2017
Universidade Católica de Brasília
2008-2016
University Center of Brasília
2016
Instituto de Saúde
2013
Dengue virus (DENV) is currently causing epidemics of unprecedented scope in endemic settings and expanding to new geographical areas. It therefore critical track this using genomic surveillance. However, the complex patterns viral diversity make it challenging use existing genotype classification system. Here, we propose adding 2 sub-genotypic levels classification, named major minor lineages. These lineages have high thresholds for phylogenetic distance clade size, rendering them stable...
The aim of this study was to investigate the effects two consecutive Crossfit® training sessions (24 hours apart) designed enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate glucose. Nine male members CrossFit® community (age 26.7 ± 6.6 years; body mass 78.8 13.2 kg; fat 13.5 6.2 %; experience 2.5 1.2 years) completed experimental protocols apart): 1) strength power 2) gymnastic movements 3) metabolic conditioning as...
Schistosomiasis is the infection caused by Schistosoma mansoni and constitutes a worldwide public health problem. The parasitological recommended method serological methods can be used for detection of eggs antibodies, respectively. However, both have limitations, especially in low endemicity areas. Thus, new approaches diagnosis schistosomiasis are essential. In this study, six-amino acid peptide derived sequences from SmATPDase1 were synthesized evaluation immunogenicity. included protein...
Dengue, caused by DENV 1-4, remains a global public health concern, with Brazil experiencing some of the largest epidemics. The reemergence DENV-3 in between 2023 and 2024 has raised concerns about new outbreaks due to absence sustained circulation this serotype recent years. This study investigates dynamics Brazil, focusing on spread 3III_B.3.2 lineage within genotype 3III its introduction routes. We analyzed 1,536 genomes, all classified as 3III, dominant since 2001. Phylogenetic analysis...
Objetivo: Examinar a prevalência, os mecanismos patofisiológicos e as abordagens de manejo da doença hepática em pacientes com fibrose cística, foco na identificação fatores que influenciam progressão eficácia das intervenções terapêuticas atuais. Métodos: Trata-se um estudo revisão bibliográfica integrativa, utilizando o PubMed como base dados. Os termos pesquisa incluíram “fibrose cística”, “doença hepática” seus derivados. No total, foram selecionados analisados 11 artigos. Resultados: A...
Toxoplasmosis is an alarming public health problem that affects more than one-third of the world's population. In our work, we investigated antiparasitic effects catalytically active [BpMP-I and Jararhagin (Jar)] inactive [Jararhagin-C (Jar-C)] snake venom metalloproteinases (SVMPs) in human HeLa cells. These toxins impaired parasite invasion intracellular growth, modulated IL-6, IL-8, MIF cytokines control cell susceptibility response against T. gondii. Furthermore, verified antiprotozoal...
<i>Objective:</i> The increase in inflammatory activity associated with aging is a characteristic of chronic disease processes that accounts for most the mortality elderly. Resistance training (RT) has been shown to promote metabolic and functional benefits this population. objective study was investigate association between long-term RT circulating levels proinflammatory mediators IL-6, TNF-α IFN-γ elderly women. <i>Methods:</i> This cross-sectional included 54 older...
Summary Chronic inflammation has been identified as an important component of metabolic syndrome ( M et S ). Inhibition the inflammatory mediator signals is a promising strategy against insulin resistance, atherosclerosis and other problems associated with . Regular exercise decreases components , including cytokines. However, relationship between acute resistance training RT ) session, cytokine levels unclear. Therefore, aim was to evaluate effects single bout on tumour necrosis factor TNF...
The present study aimed to determine whether Irisin levels are correlated with body composition changes following 16 weeks of resistance training (RT) in older women and without obesity. Design, Setting, Participants, Intervention: We recruited 49 inactive (n = 23, non-obese: < 41.0% n 26, obese: ≥ fat) aged 61-68 years perform 16-week RT consisting 10 exercises (three sets exercises, 6-12 repetitions maximum 1-min 30-s rest intervals between respectively) two sessions per week.
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide, and bears remarkable evidence for a differential prevalence among continental populations. In this scenario, estimating ancestry proportions in recently admixed populations strategy that can help increasing knowledge about genetic structure complex trait. Aim/Methods: Our purpose was to assess mean estimates three main parental contributors Brazilian contingent (European, African Amerindian) using panel 12...
Snakes of the Philodryadini tribe are included in Dipsadidae family, which is a diverse group rear-fanged snakes widespread different ecological conditions, including habitats and diet. However, little known about composition effects their venoms despite relevance for understanding evolution these or even impact on occasional cases human envenoming. In this study, we integrated venom gland transcriptomics, proteomics functional assays to characterize from eight species tribe, includes genus...
In this work, we combined molecular modeling, computational docking and in vitro analysis to explore the antileishmanial effect of some resveratrol analogs (ResAn), focusing on their pro-oxidant effect. The target was trypanothione reductase Leishmania braziliensis (LbTryR), an essential component antioxidant defenses trypanosomatid parasites. Three-dimensional structures LbTryR were modeled studies ResAn1-5 compounds showed following affinity: ResAn1 > ResAn2 ResAn4 ResAn5 ResAn3. Positive...
Abstract There is scientific evidence to suggest that the medicinal mushroom Agaricus blazei Murrill (AbM) has immunomodulatory effects on cytokine synthesis, both in vitro and vivo. This study was first randomized, double‐blind, placebo‐controlled trial designed investigate these purported actions elderly women. The objective of this ascertain AbM intake serum levels interleukin‐6 (IL‐6), interferon‐gamma (IFN‐γ) tumour necrosis factor‐alpha (TNF‐α) community‐living seniors. sample...
<b><i>Background:</i></b> Single-nucleotide polymorphisms in genes encoding immunological mediators can affect the biological activity of these molecules by regulating transcription, translation, or secretion, modulating genetic risk inflammatory damage Alzheimer's disease (AD). Nonetheless, Brazilian contingent is highly admixed, and few association trials performed herein with AD patients have considered ancestry estimates as co-variables when investigating markers...
OBJECTIVES:The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed.The current cross-sectional study investigated the association Klotho haplotypes serum levels with classic risk factors a clinical history events.METHODS: Clinical, anthropometric, biochemical nutritional assessments were conducted 168 older adults, complemented by genotyping (rs9536314 rs9527025) detection (ELISA).RESULTS: did not associate most events,...
Schistosomiasis, caused by parasites of the genus Schistosoma, is a neglected disease with high global prevalence, affecting more than 240 million people in several countries. Praziquantel (PZQ) only drug currently available for treatment. S. mansoni NTPDases (known as SmNTPDases, ATP diphosphohydrolases or ecto-apyrases) are potential targets discovery new antischistosomal drugs. In this study, we screen inhibitors from Centella erecta (Apiaceae) using an ultrafiltration combined...
Abstract Influenza A and B viruses represent significant global health threats, contributing substantially to morbidity mortality rates. However, a comprehensive understanding of the molecular epidemiology these in Brazil, continental-size country crucial hub for entry, circulation, dissemination influenza within South America, still needs be improved. This study addresses this gap by consolidating data samples across all Brazilian macroregions, as part Center Viral Surveillance Serological...
Antimicrobial resistance is considered a health issue worldwide. This public problem underscores the importance of searching for new antimicrobial molecules with different mechanisms action. Leaf transcriptomes were used to search and develop synthetic peptides derived from mRNA sequences. The in silico AMPs L. rotundifolia alba allowed identification 120 putative peptide Eight them fitted into optimal parameters translated chemically synthesized peptides. Their biological activity was...