A5101852998- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Venomous Animal Envenomation and Studies
- Synthesis and Biological Evaluation
- Insect and Pesticide Research
- Signaling Pathways in Disease
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Cell Adhesion Molecules Research
- Insect symbiosis and bacterial influences
- Nonmelanoma Skin Cancer Studies
- Healthcare and Venom Research
- Nanoplatforms for cancer theranostics
- Genetics and Plant Breeding
- Soybean genetics and cultivation
- Oral microbiology and periodontitis research
- Pain Mechanisms and Treatments
- Phytochemistry Medicinal Plant Applications
- Toxin Mechanisms and Immunotoxins
- Genetic Syndromes and Imprinting
- Phytochemical compounds biological activities
- Parasitic Infections and Diagnostics
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Quinazolinone synthesis and applications
Universidade Federal de Uberlândia
2015-2024
San Antonio College
2019
Bayer (France)
2019
Hospital Nossa Senhora da Conceição
2019
Centro Universitário do Triângulo
2017
Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has diverse chemical constitution but the biological activities its essential oils not been thoroughly investigated. aims this paper were to evaluate vitro cytotoxic, antifungal and antibacterial oil from leaves B. identify main constituents. was extracted by steam distillation, composition determined gas chromatography/mass...
Abstract Chagas disease, which is caused by the parasite Trypanosoma cruzi, an important cause of cardiomyopathy in Latin America. It estimated that 10%–30% all infected individuals will acquire chronic chagasic (CCC). The etiology CCC multifactorial and involves genotype, host genetic polymorphisms, immune response, signaling pathways autoimmune progression. Herein we verified impact recombinant form P21 (rP21), a secreted T. cruzi protein involved cell invasion, on progression inflammatory...
Abstract The combination of pyrimethamine and sulfadiazine is the standard care in cases congenital toxoplasmosis. However, therapy with these drugs associated severe sometimes life-threatening side effects. investigation phytotherapeutic alternatives to treat parasitic diseases without acute toxicity essential for advancement current therapeutic practices. present study investigates antiparasitic effects oleoresins from different species Copaifera genus against T. gondii . Oleoresins C....
P21 is a protein secreted by Trypanosoma cruzi (T. cruzi). Previous studies have shown spectrum of biological activities performed such as induction phagocytosis, leukocyte chemotaxis and inhibition angiogenesis. However, the activity in T. infection remains unknown. Here, we reported role mice harboring late infection. Treatment with recombinant (rP21) reduced parasite load angiogenesis, induced fibrosis cardiac tissue infected mice. In addition, rP21 growth epimastigotes, inhibited...
Abstract Ruthenium complexes have been extensively explored as potential molecules for cancer treatment. Considering our previous findings on the remarkable cytotoxic activity exhibited by ruthenium (II) complex 3-hydroxy-4-methoxybenzoate (hmxbato)- cis -[Ru II (ŋ 2 -O CC 7 H O )(dppm) ]PF 6 against Leishmania promastigotes and also similar metabolic characteristics between trypanosomatids tumor cells, present study aimed to analyze anticancer of hmxbato lung well partial death mechanisms...
Trypanosoma cruzi P21 protein (P21) is a putative secreted and immunomodulatory molecule with potent bioactive properties such as induction of phagocytosis actin cytoskeleton polymerization. Despite the described so far, action on parasite replication in muscle cell lineage or T. parasitism during acute experimental infection unclear. We observed that recombinant (rP21) decreased multiplication C2C12 myoblasts, phenomenon associated greater polymerization IFN-γ IL-4 higher expression. During...
Abstract Class 1 myosins (Myo1s) were the first unconventional identified and humans have eight known Myo1 isoforms. The family is involved in regulation of gene expression, cytoskeletal rearrangements, delivery proteins to cell surface, migration spreading. Thus, important role Myo1s different biological processes evident. In this study, we investigated effects pentachloropseudilin (PClP), a reversible allosteric potent inhibitor Myo1s, on angiogenesis. We demonstrated that treatment cells...
Leishmania (L.) amazonensis is one of the species responsible for development cutaneous leishmaniasis in South America. After entering vertebrate host, L. invades mainly neutrophils, macrophages and dendritic cells. Studies have shown that gal-3 acts as a pattern recognition receptor. However, role this protein context infection remains unclear. Here, we investigated impact expression on experimental by amazonensis. Our data showed plays controlling parasite invasion, replication formation...
Leishmaniasis causes alterations and lesions in the genital system, which leads to azoospermia testicular atrophy animals during chronic phase of infection. The aim this study was reveal kinetics Leishmania chagasi infection system male golden hamsters (Mesocricetus auratus). Animals were intraperitoneally inoculated with amastigotes from L. chagasi. At different time points euthanized organs processed for histo-pathological, qPCR, cytokines testosterone detection assays. Our results showed...
Agroflorestas urbanas integram árvores frutíferas, plantas medicinais e vegetais em espaços urbanos. Estudou-se seu potencial para segurança alimentar, sustentabilidade bem-estar comunitário Tangará da Serra, MT, por meio de uma revisão bibliográfica, visando contribuir o objetivo 11 Agenda 2030. Palavras-chave: urbanas. Produção alimentos. Qualidade do ar. Biodiversidade. Ambientes urbanos saudáveis. Serra-MT.
Introduction: Skin cancer is the most common neoplasm malignancy worldwide and subdivided into melanoma not melanoma. Brazil, being a tropical country with high incidence of UV rays, one countries in world affected by this type neoplasia. Objective: To describe profile patients skin northern region period from 2014 to 2019, using data reported present DATASUS. Method: Historical series cases North between years accounted for through DATASUS platform. Results: In last 5 years, 2,610 were...