A5013999380- Venomous Animal Envenomation and Studies
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Neurobiology and Insect Physiology Research
- Laser Design and Applications
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Bioactive Natural Diterpenoids Research
- Advanced Nanomaterials in Catalysis
- Calpain Protease Function and Regulation
- Quantum Dots Synthesis And Properties
- Research on Leishmaniasis Studies
- Spectroscopy and Laser Applications
- Cholinesterase and Neurodegenerative Diseases
- Metal complexes synthesis and properties
- Cell death mechanisms and regulation
- Food Allergy and Anaphylaxis Research
- Protein Hydrolysis and Bioactive Peptides
- Metal-Catalyzed Oxygenation Mechanisms
- interferon and immune responses
- Nanocluster Synthesis and Applications
- Marine Sponges and Natural Products
- Synthesis and Biological Evaluation
- Nanoplatforms for cancer theranostics
- S100 Proteins and Annexins
Universidade Federal de Uberlândia
2018-2024
University of British Columbia
2010
Universität Hamburg
2002
Abstract Alzheimer’s disease (AD) is the most common form of dementia in elderly, affecting cognitive, intellectual, and motor functions. Different hypotheses explain AD’s mechanism, such as amyloidogenic hypothesis. Moreover, this multifactorial, several studies have shown that gut dysbiosis oxidative stress influence its pathogenesis. Knowing kefir a probiotic used therapies to restore bioactive peptides present it antioxidant properties, we explored biotechnological potential source...
This work reports the biological evaluation of a copper complex type [Cu(O-O)(N-N)ClO4], in which O-O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N-N 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect CBP-01 was evaluated by resazurin assay cell proliferation determined MTT assay. DNA fragmentation analyzed gel electrophoresis. Cell cycle progression detected through propidium iodide (PI) staining. Apoptosis autophagy were by, respectively, Annexin V...
Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living organisms, with broad spectrum pharmacological activities and therapeutic potential. Anti-angiogenic strategies have become one the main tools fighting cancer. In this sense, present work reports inhibition tumor angiogenesis induced by Asp-49 BthTX-II using vitro, ex vivo approaches. We demonstrate that BthTx-II inhibited cell adhesion, proliferation, migration human umbilical vein endothelial cells...
Triple-negative breast cancers (TNBCs) are more aggressive than other cancer (BC) subtypes and lack effective therapeutic options. Unraveling marker events of TNBCs may provide new directions for development strategies targeted TNBC therapy. Herein, we reported that Annexin A1 (AnxA1) Cathepsin D (CatD) highly expressed in MDA-MB-231 (TNBC lineage), compared to MCF-10A MCF-7. Since the proposed concept was CatD has protumorigenic activity associated with its ability cleave AnxA1 (generating...
Abstract The hypothesis that adaptation to local environments can increase mating success was tested using ten replicate lines of Drosophila melanogaster adapted either 16 °C or 25 °C. Competitive trials at both temperatures were performed with males taken from a pair lines, one each temperature. There no average in for the environment. Although showed expected pattern, another reverse pattern. More data are needed on this hypothesis, preferably have more strongly environments.
Phospholipases A2 (PLA2) from snake venoms have a broad potential as pharmacological tools on medicine. In this context, strongyloidiasis is neglected parasitic disease caused by helminths of the genus Strongyloides. Currently, ivermectin drug choice for treatment, however, besides its notable toxicity, therapeutic failures and cases resistance been reported. BnSP-6, Bothorps pauloensis venom, PLA2 with depth biochemical characterization, reporting effects against tumor cells bacteria.The...
Some species of primitive predatory ants, despite living in a colony, exercise their hunting collection strategy individually; venom is painful, paralyzing, digestive, and lethal for prey, yet the toxins responsible these effects are poorly known. Ectatomma opaciventre previously unrecorded solitary ant from Brazilian Cerrado. To overcome this hindrance, present study performed vitro enzymatic, biochemical, biological activities E. to better understand properties venom. Its showed several...
The present study focuses on the first electrochemical immunosensor built with polymeric mats enriched nanomaterials, targeting dust mite protein, for detection of allergens in flour sources important implications allergic reactions. As a proof-of-concept, we have used Blo t 5 allergen from Blomia tropicalis (target) and established parameters to recognize detect specific using polyclonal immunoglobulin (Ig) Y (probe). Detection was performed portable potentiostat (EmStat) graphite...
Abstract Background: Head and neck cancer is the sixth most common site worldwide associated with low survival high mortality rates, when diagnosed in advanced stages. The pursuit for potential therapeutic targets natural resources may lead to development of new antineoplastic agents. Several compounds coming from venomous animals are being tested clinical trials due their selectivity different physiologic activities. In this way, ant-venom glands composed bioactive molecules, such as...
Summary form only given. We investigate a fibre laser based on single mode silica fibre, doped with 1000 ppm Tm/sup 3+/. The is excited by diode (70 mW at 780 nm), and it includes an intracavity absorption cell filled air or sample gases. has about 1 cw output power, call he tuned from 1.7 to 2 /spl mu/m moving the aspheric lens, which couples mirror through cell. For analysis of emission spectrum we built special rapid scan Fourier spectrometer 0.015 cm/sup -1/ spectral resolution. Due...