A5026512173- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Healthcare Regulation
- Public Health in Brazil
- Vibrio bacteria research studies
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Pressure Ulcer Prevention and Management
- Neonatal and Maternal Infections
- Patient Satisfaction in Healthcare
- Wound Healing and Treatments
- Maternal and Neonatal Healthcare
- Enterobacteriaceae and Cronobacter Research
- Health, Nursing, Elderly Care
- Infection Control in Healthcare
- Infective Endocarditis Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Infections and bacterial resistance
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
Universidade Federal de Uberlândia
2016-2025
Hospital de Sant Joan Despí Moisès Broggi
2023
The rates of multidrug-resistant, extensively drug-resistant and pandrug-resistant isolates amongst non-fermenting Gram-negative bacilli, particularly Pseudomonas aeruginosa, have risen worldwide. clinical consequence resistance the impact adverse treatment on outcome patients with P. aeruginosa bacteraemia remain unclear. To better understand predictors mortality, inappropriate therapy patient outcomes, we analysed first episode in from a Brazilian tertiary-care hospital during period May...
Pseudomonas aeruginosa is an opportunistic pathogen that causes frequently nosocomial infections, currently becoming more difficult to treat due the various resistance mechanisms and different virulence factors. The purpose of this study was determine risk factors independently associated with development bacteremia by carbapenem-resistant P. aeruginosa, frequency genes in metallo-β-lactamases producers evaluate their ability produce biofilm. We conducted a case-control Uberlândia Federal...
In Brazil, ventilator-associated pneumonia (VAP) caused by carbapenem resistant Acinetobacter baumannii and Pseudomonas aeruginosa isolates are associated with significant mortality, morbidity costs. Studies on the clonal relatedness of these could lay foundation for effective infection prevention control programs.We sought to study epidemiological molecular characteristics A. vs. P. VAP in an adult intensive care unit (ICU).It was conducted a cohort patients during 14 months ICU. Genomic...
Introduction. In critically ill patients, the occurrence of multidrug-resistant Pseudomonas aeruginosa infection is a significant concern, given its ability to acquire multidrug-resistant, form biofilms and secrete toxic effectors. Hypothesis or Gap Statement. Brazil, limited data are available regarding prevalence dissemination, impact type III secretion system (T3SS) on toxin production biofilm formation in clinical isolates P. . Aim. This study investigates dissemination virulent...
Bloodstream infections (BSI) are a major problem in intensive care units (ICUs), with increasing rates despite medical advancements. These closely tied to patient deaths and influenced by various risk factors identified through ICU research. Infections caused antibiotic-resistant Gram-negative bacilli (GNBs) negatively impact patients, especially underdeveloped countries like Brazil. This study investigated nosocomial BSI GNB among patients at Federal University of Uberlândia between 2012...
Vancomycin-resistant enterococci (VRE) are important hospital pathogens and have become increasingly common in patients admitted to the intensive care unit (ICU). To determine incidence risk factors associated with VRE colonisation among ICU patients, active surveillance cultures for faecal carriages were carried out of University Hospital Uberlândia, Minas Gerais, Brazil. Risk assessed using a case-control study. Seventy-seven (23.1%) found be colonised vanC only one patient (0.3%) was vanA...
We assessed late onset sepsis (LOS) rates of neonates in a neonatal intensive care unit (NICU) before and after implementing an evidence-based bundle to prevent these infections country with poor resources.We evaluate trends LOS between October 2010 August 2012 large tertiary hospital Brazil. designed protocol based CDC guidelines for insertion maintenance central venous catheter targeted reduction bloodstream infections. During this period two major events occurred: great increase January...
This study aimed to determine the epidemiology of three most common nosocomial infections (NI), namely, sepsis, pneumonia, and urinary tract infection (UTI), in a pediatric intensive care unit (PICU) developing country define risk factors associated with NI.We performed prospective on incidence NI single PICU, between August 2009 2010. Active surveillance by National Healthcare Safety Network (NHSN) was conducted children (cases) were compared group (matched controls) case-control fashion.We...
We described a comprehensive analysis of the molecular epidemiology multidrug-resistant (MDR) P. aeruginosa. Molecular included typing by Pulsed Field Gel Electrophoresis, identification genes interest through PCR-based assays and sequencing target genes. Case-control study was conducted to better understand prognostic patients impact inappropriate therapy in with bacteremia, as well risk factors MDR infections. observed high rate isolates (40.7%), 51.0% them independently associated...
The bacterial factors associated with bacteremia by multidrug-resistant and extensively drug-resistant P. aeruginosa, including overexpression of efflux pumps, AmpC overproduction, loss/alteration the OprD porin in isolates that are non-Metallo-β-Lactamase producing were analyzed a retrospective study. Molecular analyses included strain typing Pulsed Field Gel Electrophoresis identification key genes via qualitative quantitative PCR-based assays. Previous use carbapenems tracheostomy was...
In this study, we describe the frequency of virulence genes in Klebsiella pneumoniae carbapenemase-2-producing (KPC-KP), including hypervirulent (hv) and hypermucoviscous (hm) strains by whole-genome sequencing. We also evaluate capacity for biofilm formation using phenotypic techniques. The occurrence several (fimABCDEFGHIK, mrkABCDFHJ, ecpA, wabG, entB, ugE, irp1, irp2, traT, iutA ureADE) a high hvhmKPC-KP isolates was found. Most hospital-associated lineages KPC-KP belong to international...