A5036419309- Folate and B Vitamins Research
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Glutathione Transferases and Polymorphisms
- Down syndrome and intellectual disability research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Neurofibromatosis and Schwannoma Cases
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Genomics, phytochemicals, and oxidative stress
- Gestational Diabetes Research and Management
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Nonmelanoma Skin Cancer Studies
- Cancer Cells and Metastasis
- Connective tissue disorders research
- Colorectal Cancer Treatments and Studies
- Meningioma and schwannoma management
- Iron Metabolism and Disorders
- Fibroblast Growth Factor Research
- RNA Research and Splicing
Faculdade de Medicina de São José do Rio Preto
2016-2025
Universidade Federal do Triângulo Mineiro
2016
Hospital de Base
2016
Creative Research Enterprises (United States)
2016
Biolog (United States)
2016
Universidade de São Paulo
2014
Universidade Federal de São Carlos
2008
Universidade Estadual de Campinas (UNICAMP)
2007
United States Nuclear Regulatory Commission
2004
Universidade Estadual Paulista (Unesp)
1995-1997
Functional polymorphisms in promoter regions can produce changes the affinity of transcription factors, thus altering messenger ribonucleic acid (mRNA) expression levels inflammatory cytokines associated with risk cancer development. The goal this study was to evaluate influence that cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on mRNA risks chronic gastritis (CG) gastric...
The aim of the present study was to investigate effect polymorphisms C677T and A1298C in methylenetetrahydrofolate reductase (MTHFR) gene, A2756G methionine synthase (MTR) gene A80G reduced folate carrier 1 (RFC1) plasma homocysteine (Hcy), on maternal risk for Down syndrome (DS).Seventy-two DS mothers 194 who had no children with were evaluated.The investigation MTHFR C677T, MTR RFC1 performed by polymerase chain reaction enzyme digestion polymorphism allele-specific reaction.Hcy...
No mundo, aproximadamente 200 mil casos novos de câncer cabeça e pescoço são diagnosticados anualmente. Uma média 13.470 cavidade oral por 100 habitantes é observada no Brasil. OBJETIVO: Analisar os aspectos clínicos epidemiológicos dos pacientes atendidos Serviço Otorrinolaringologia Cirurgia Cabeça Pescoço em um hospital universitário do Noroeste Estado São Paulo, CASUÍSTICA E MÉTODOS: Foram analisados dados 427 período 2000 a 2005. As variáveis analisadas incluíram idade, sexo, profissão,...
Liver cirrhosis (LC) is a heterogeneous liver disease, the last stage of fibrosis, and major risk factor for hepatocellular carcinoma (HCC). Our study aimed to evaluate expression microRNAs endothelial vascular growth (VEGFA) gene in LC HCC.The sample group consisted 46 tissue samples: 21 LC, 15 HCC, 10 non-tumoural non-cirrhotic (control group). MiRNAs were chosen based on mirDIP prediction database as regulators VEGFA gene. Gene VEGF miRNAs was quantified by real-time quantitative...
Introduction: Joint hypermobility (JH) is mobility beyond the normal range of motion. JH can be an isolated finding or a characteristic syndrome. Characteristics related to sitting position with atypical body positions, such as in splits (S), foot on head (F), W (W), concave shape (C), episodes dislocations, and subluxations, suggest impacts mechanics since childhood, damage conformation joints. Objectives: Identify preclinical signs JH, addition Beighton Score (BS), through that are easily...
Head and neck cancer (HNC) is one of the most common types in world, characterized by resistance to conventional therapies an unfavorable prognosis due presence tumor stem cells (TSCs). TSCs are cell subpopulations with high potential for invasion, migration, metastasis, being responsible initiation dissemination cancer. This study aimed evaluate efficacy treatments cetuximab paclitaxel, alone combination, from oral cavity (SCC-28) hypopharynx (FADU) lines. In addition, influence gene...
Xia‒Gibbs syndrome (XGS) is a rare intellectual disability (ID) caused by de novo AHDC1 pathogenic variants. We characterized clinical and molecular features of 16 Brazilian patients with XGS. Patient data were collected through semistructured interviews family members, reanalysis previous health genetic assessments, reports from physicians. Genomic variants their segregation validated via Sanger sequencing. Statistical analyses conducted to evaluate genotype‒phenotype associations. Twelve...
Xia‒Gibbs syndrome (XGS) is a rare intellectual disability (ID) caused by de novo AHDC1 pathogenic variants. We characterized clinical and molecular features of 16 Brazilian patients with XGS. Patient data were collected through semistructured interviews family members, reanalysis previous health genetic assessments, reports from physicians. Genomic variants their segregation validated via Sanger sequencing. Statistical analyses conducted to evaluate genotype‒phenotype associations. Twelve...
Head and neck cancer is the fifth most common type of worldwide. The objective this study was to evaluate clinical epidemiological parameters in a head surgery service.
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate influence 12 genetic polymorphisms involved metabolism on DS. In addition, we evaluated impact these serum and plasma methylmalonic acid (MMA, an indicator vitamin B<formula>_{12}</formula> status) concentrations. transcobalamin II (TCN2) c.776C>G, betaine-homocysteine S-methyltransferase (BHMT) c.742A>G, methylenetetrahydrofolate...
Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate influence 12 genetic polymorphisms involved metabolism on DS. In addition, we evaluated impact these serum and plasma methylmalonic acid (MMA, an indicator vitamin B status) concentrations. transcobalamin II (TCN2) c.776C>G, betaine-homocysteine S-methyltransferase (BHMT) c.742A>G, methylenetetrahydrofolate reductase (NAD(P)H)...
Neurofibromatoses (NF) are a group of genetic multiple tumor growing predisposition diseases: neurofibromatosis type 1 (NF1), 2 (NF2) and schwannomatosis (SCH), which have in common the neural origin tumors cutaneous signs. They affect nearly 80 thousand Brazilians. In recent years, increased scientific knowledge on NF has allowed better clinical management reduced complication morbidity, resulting higher quality life for patients. most cases, neurology, psychiatry, dermatology, geneticists,...
Background: Alteration in the biotransformation of exogenous compounds can result production reactive oxygen species (ROS), which predispose cells to malignant transformation head and neck. This study aimed evaluate expression genes involved antioxidant metabolism oral squamous cell carcinoma (OSCC). Methods: The eighty-four was evaluated OSCC non-tumor tissues by quantitative real-time polymerase chain reaction using TaqMan Gene Expression Array. biological mechanisms related differentially...
Head and neck cancer accounts for nearly 200.000 new cases worldwide. A mean of 13.470 in the oral cavity 100.000 inhabitants is observed Brazil.