A5106670727- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Viral-associated cancers and disorders
- Genomics, phytochemicals, and oxidative stress
- Gastric Cancer Management and Outcomes
- Glutathione Transferases and Polymorphisms
- Gene Regulatory Network Analysis
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Computational Drug Discovery Methods
- Biotin and Related Studies
- Oral Health Pathology and Treatment
- Poxvirus research and outbreaks
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Esophageal Cancer Research and Treatment
- Blood Pressure and Hypertension Studies
- Circular RNAs in diseases
- CAR-T cell therapy research
- Health, Nursing, Elderly Care
Universidade Estadual da Paraíba
2010-2024
Universidade de São Paulo
2005-2011
Fox Chase Cancer Center
2010
University of Kentucky
2010
University of Louisville
2010
Brazilian Society of Computational and Applied Mathematics
2008
Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material cellular communication, their molecular cargo during is relatively unknown. In this study, we evaluated the presence microRNAs (miRNAs) messenger RNAs (mRNAs) inflammatory response redox metabolism in exosomes septic shock. Blood samples were...
Abstract Lung cancer is the leading cause of deaths in United States, surpassing breast as primary cancer-related mortality women. The goal present study was to identify early molecular changes lung induced by exposure tobacco smoke and thus potential targets for chemoprevention. Female A/J mice were exposed either or HEPA-filtered air via a whole-body chamber (6 h/d, 5 d/wk 3, 8, 20 weeks). Gene expression profiles tissue from control smoke-exposed animals established using 15K cDNA...
To estimate the prevalence of vitamin A deficiency and its associated factors in children.A cross-sectional population-based study, involving 1,211 children both sexes, aged between six 59 months old, was carried out urban zone 9 cities state Paraiba, Northeastern Brazil. Vitamin status assessed by serum retinol levels (high performance liquid chromatography - HPLC) subclinical infection C-reactive protein concentrations. Socioeconomic, demographic sanitation conditions, as well supplement...
A wide variety of high-throughput microarray platforms have been used to identify molecular targets associated with biological and clinical tumor phenotypes by comparing samples representing distinct pathological states. The gene expression profiles human cutaneous melanomas were determined cDNA analysis. Next, a robust analysis determine functional classifications make predictions based on data-oriented hypotheses was performed. Relevant networks that may be implicated in melanoma...
Abstract Adenocarcinomas of stomach and esophagus are frequently associated with preceding inflammatory alterations the normal mucosa. Whereas intestinal metaplasia gastric mucosa is higher risk malignization, Barrett's disease a factor for adenocarcinoma esophagus. characterized by substitution squamous columnar tissue classified histopathologically as metaplasia. Using cDNA microarrays, we determined expression profile esophageal well adenocarcinomas from both organs. Data were explored to...
Persistent infection by high risk HPV types (e.g. HPV-16, -18, -31, and -45) is the main factor for development of cervical intraepithelial neoplasia cancer. Tumor necrosis (TNF) a key mediator epithelial cell inflammatory response exerts potent cytostatic effect on normal or HPV16, but not HPV18 immortalized keratinocytes. Moreover, several carcinoma-derived lines are resistant to TNF anti-proliferative suggesting that acquisition TNF-resistance may constitute an important step in...
Estimar a prevalência de hipertensão arterial sistêmica (HAS) e fatores associados em idosos Campina Grande/Paraíba. Estudo transversal, base populacional. Foram verificadas prevalências HAS diagnosticada, referida, controlada associações com variáveis sociodemográficas. avaliados 806 idosos. A diagnosticada associou‐se ao sexo feminino, grupo etário 70‐79 anos menos 8 estudo. referida feminino à etnia não branca. branca ou mais Idosos apresentaram elevadas baixo controle da doença. To...
Smallpox is a lethal disease that was endemic in many parts of the world until eradicated by massive immunization. Due to its lethality, there are serious concerns about use as bioweapon. Here we analyze publicly available microarray data further understand survival smallpox infected macaques, using systems biology approaches. Our goal improve knowledge progression this disease. We used KEGG pathways annotations define groups genes (or modules), and subsequently compared them macaque times....
High-dimensional gene expression data cause challenges for traditional statistical tools, particularly when dealing with non-linear relationships and outliers. The present study addresses these by employing a generalized correlation coefficient (GCC) that incorporates flexibility parameter, allowing it to adapt varying levels of symmetry asymmetry in the distribution. This adaptability is crucial analyzing association networks, where GCC demonstrates advantages over measures such as Kendall,...
Abstract Motivation: Gene expression data analysis is of great importance for modern molecular biology, given our ability to measure the profiles thousands genes and enabling studies rooted in systems biology. In this work, we propose a simple statistical model activation measuring gene regulatory networks, instead traditional co-expression networks. Results: We present mathematical construction procedure testing hypothesis regarding network activation. The real probability distribution test...
<div>Abstract<p>Lung cancer is the leading cause of deaths in United States, surpassing breast as primary cancer-related mortality women. The goal present study was to identify early molecular changes lung induced by exposure tobacco smoke and thus potential targets for chemoprevention. Female A/J mice were exposed either or HEPA-filtered air via a whole-body chamber (6 h/d, 5 d/wk 3, 8, 20 weeks). Gene expression profiles tissue from control smoke-exposed animals established...
<div>Abstract<p>Lung cancer is the leading cause of deaths in United States, surpassing breast as primary cancer-related mortality women. The goal present study was to identify early molecular changes lung induced by exposure tobacco smoke and thus potential targets for chemoprevention. Female A/J mice were exposed either or HEPA-filtered air via a whole-body chamber (6 h/d, 5 d/wk 3, 8, 20 weeks). Gene expression profiles tissue from control smoke-exposed animals established...
Abstract Lung cancer is the leading cause of deaths in U.S., surpassing breast as primary cancer-related mortality women. The goal present study was to identify early molecular changes lung induced by exposure tobacco smoke and thus potential targets for chemoprevention. Female A/J mice were exposed either or HEPA-filtered air via a whole-body chamber (6 h/day; 5 days/wk 3, 8 20 wk). Gene expression profiles tissue from control smoke-exposed animals established using 15 K cDNA microarray....