A5085649655- Advanced Glycation End Products research
- Sphingolipid Metabolism and Signaling
- Connexins and lens biology
- Berberine and alkaloids research
- Heme Oxygenase-1 and Carbon Monoxide
- Software System Performance and Reliability
- Genomics, phytochemicals, and oxidative stress
- Chronic Kidney Disease and Diabetes
- Endoplasmic Reticulum Stress and Disease
- Cholesterol and Lipid Metabolism
- Advanced Software Engineering Methodologies
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Natural Antidiabetic Agents Studies
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Software Engineering Research
- Protein Kinase Regulation and GTPase Signaling
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Connective Tissue Growth Factor Research
- Curcumin's Biomedical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
Guangzhou Medical University
2017-2024
Guangzhou Eighth People's Hospital
2017-2024
Jinan University
2023
Xidian University
2022-2023
Sun Yat-sen University
2011-2019
First Affiliated Hospital of Zhengzhou University
2018
The First Affiliated Hospital, Sun Yat-sen University
2014-2016
Guangdong Pharmaceutical University
2011
Johns Hopkins University
2004
Diabetic nephropathy is characterized by accumulation of glomerular extracellular matrix proteins, such as fibronectin (FN). Here, we investigated whether sphingosine kinase (SphK)1 pathway responsible for the elevated FN expression in diabetic nephropathy. The SphK1 and were examined streptozotocin-induced rat kidney mesangial cells (GMC) exposed to high glucose (HG). up-regulation was concomitant with activation reflected an increase activity 1-phosphate (S1P) production both HG-treated...
The accumulation of glomerular extracellular matrix (ECM) is one the critical pathological characteristics diabetic renal fibrosis. Fibronectin (FN) an important constituent ECM. Our previous studies indicate that activation sphingosine kinase 1 (SphK1)-sphingosine 1- phosphate (S1P) signaling pathway plays a key regulatory role in FN production mesangial cells (GMCs) under condition. Among five S1P receptors, S1P2 receptor most abundant. Berberine (BBR) treatment also effectively inhibits...
We previously demonstrated that advanced glycation-end products (AGEs) promote the pathological progression of diabetic nephropathy by decreasing silent information regulator 2-related protein 1 (Sirt1) expression in glomerular mesangial cells (GMCs). Here, we investigated whether AGEs-receptor for AGEs (RAGE) system down-regulated Sirt1 through ubiquitin-proteasome pathway and ubiquitination affected fibronectin (FN) TGF-β1, 2 fibrotic indicators GMCs. was polyubiquitinated subsequently...
The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation amyloid-beta (Aβ) and intraneuronal aggregation hyperphosphorylated tau in the brain. Development disease-modifying treatment for AD has been challenging. Recent studies suggest that deleterious alterations neurovascular cells happens parallel Aβ accumulation, inducing pathology necroptosis. Therefore, therapies targeting cellular pathologies may provide a more effective strategy...
Abstract Hyperglycemia-induced renal epithelial-to-mesenchymal transition (EMT) is a key pathological factor in diabetic tubulointerstitial fibrosis (RIF). Our previous studies have shown that connexin 43 (Cx43) activation attenuated the development of fibrosis. However, whether Cx43 regulates EMT tubular epithelial cells (TECs) and process RIF under conditions remains to be elucidated. In present study, we identified protein expression was down-regulated kidney tissues db/db mice as well...
Recently, it is implicated that the abnormality of Akt signaling pathway involved in diabetic pathology. Previous studies have demonstrated berberine could decrease blood glucose by elevating liver glycogen synthesis. However, underlying mechanism still unclear. In present study, we investigated effects on fasting glucose, glycogen, Akt, Glycogen synthase kinase-3, glucokinase and insulin receptor substrate (IRS) alloxan-induced mice, exploring its possible hypoglycemic mechanism. We found...
Nuclear factor kappa-B (NF-κB) signalling plays an important role in diabetic nephropathy. Altered expression of connexin43 (Cx43) has been found kidneys animals. The aim the current study was to investigate Cx43 activation NF-κB induced by high glucose glomerular mesangial cells (GMCs) and determine whether c-Src is involved this process.We that downregulation activated GMCs. Orverexpression attenuated p65 nuclear translocation glucose. High inhibited interaction between c-Src, enhanced...
Unlike peripheral nervous system neurons and certain groups of nerve cells in the CNS, cortical projection are tolerant axonal lesions. This resistance is incongruent with massive death pyramidal age-associated neurodegenerative diseases that proceed along corticocortical connections. Some insights have emerged from our previous work showing piriform cortex undergo classical apoptosis within 24 h after bulbectomy via transsynaptic, but not retrograde, signaling. These findings allow...
Background and Purpose Nox4 is the major isoform of NADPH oxidase found in kidney contributes to pathogenesis diabetic nephropathy. However, molecular mechanisms increased expression induced by hyperglycaemia remain be elucidated. Here, role connexin32–Nox4 signalling axis nephropathy its related were investigated. Experimental Approach Diabetes was mice low‐dose streptozotocin (STZ) combined with a high‐fat diet. Effects connexin32 on renal function fibrosis STZ‐induced investigated using...