A5003332833- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- RNA Research and Splicing
- Retinal Development and Disorders
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Cancer, Lipids, and Metabolism
- Breast Lesions and Carcinomas
- Lung Cancer Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic and Hepatic Oncology Research
- AI in cancer detection
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Inflammatory Biomarkers in Disease Prognosis
Renji Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Jiangmen Central Hospital
2024
Xuzhou Medical College
2021
East China Normal University
2021
Recent evidence shows that inducing ferroptosis may improve efficacy of tumor therapy. However, ferroptosis-related genes have been little studied in patients with breast cancer especially the neoadjuvant setting. ACSL4 and GPX4 well established as positive negative regulator ferroptosis, respectively. This study aimed to explore predictive value for administered chemotherapy.This included treated paclitaxel-cisplatin-based chemotherapy. Immunohistochemistry staining was carried out on core...
Triple negative breast cancer (TNBC) is a subtype of with poor prognosis and lack effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis identified CARMN as downregulated lncRNA which lowest in TNBC. We aimed to identify the potential role molecular mechanisms TNBC.Predictive value was explored cohorts. TNBC cell lines overexpression or silence were used for vitro vivo experiments. RNA-seq overexpressed cells performed exploring...
Abstract Background Upregulation of the PD-L1 (CD274) immune checkpoint ligand on tumor surface facilitates escape and limits application immunotherapy in various cancers, including breast cancer. However, mechanisms underlying high levels cancers are still poorly understood. Methods Bioinformatics analyses vivo vitro experiments were carried out to assess association between CD8 + T lymphocytes TIMELESS (TIM) expression, discover TIM, transcription factor c-Myc, cancer cell lines. Results...
Aim: To systematically profile and characterize the circular RNA (circRNA) expression pattern in estrogen receptor (ER)-positive breast cancer (BC). Materials & methods: CircRNA was performed ER-positive BC adjacent nontumor tissues. The differentially expressed circRNAs (DECs) analyzed by bioinformatics. analysis findings were validated quantitative real-time PCR. Results: In total, 3653 DECs detected our compared with control. Bioinformatics showed that some pathways related to cancer,...
The communication between tumor cells and microenvironment plays a critical role in cancer development. Cancer-associated fibroblasts (CAFs) are the major components of take part breast formation progression. Here, by comparing gene expression patterns CAFs normal fibroblasts, we found SPRY2 was significantly decreased correlated with worse prognosis patients. knockdown promoted growth distant metastasis mice. Loss stromal CAF activation dependent on glycolytic metabolism. Mechanically,...
Since the poor prognosis of uveal melanoma with distant metastasis, we intended to screen out possible biomarkers for metastasis risk and establish a nomogram model predicting (UVM) metastasis.
Novel lymphocyte to red blood cell ratio (LRR), neutrophil (NRR), monocyte (MRR) as predictive and prognostic biomarkers for locally advanced breast cancer
Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) various kinds cancers. Here, we aimed to determine whether expression ZEB1 protein related response patients neoadjuvant therapy as well their survival outcome.Immunohistochemistry (IHC) was performed on paraffin-embedded tumor samples from core needle biopsy before (NAT). Univariate and multivariate logistic regression analyses were used analyze associations...
Linc00665 is a novel long non-coding RNA that can promote the progression of breast cancer, but its value in predicting efficacy neoadjuvant chemotherapy (NAC) for cancer has not been reported. We aim to analyze correlation between expression and pathological complete response (pCR) patients. The present study examined predictive role pCR after NAC using both univariate multivariate logistic regression analyses. Receiver operating characteristic (ROC) curve area under (AUC) were utilized...
Hypoxia-induced chemotherapy resistance is the main hindrance for solid tumor treatment. Hypoxia inducible factor-1α (HIF1α), an adaptive gene of hypoxia condition, played important role in affecting sensitivity many cancer types and various therapeutic regimens. This study focused on impact HIF1α predicting response survival taxane-based neoadjuvant therapy (NAT) breast (BC) patients concrete mechanism that mediated paclitaxel chemo-insensitivity. We evaluated expression...
Abstract Background MicroRNA-1 (miR-1) is a tumour suppressor that can inhibit cell proliferation and invasion in several cancer types. In addition, miR-1 was found to be associated with drug sensitivity. Circulating miRNAs have been proven potential biomarkers predictive prognostic value. However, studies of expression the serum breast (BC) patients are relatively scarce, especially receiving neoadjuvant chemotherapy (NAC). Methods Serum samples from 80 were collected before chemotherapy,...
Background: EPIC1 is an oncogenic long non-coding ribonucleic acid (RNA) that promotes cell growth and cell-cycle progression inhibits apoptosis in several cancer lines. However, clinical studies on breast cancer, specifically the neoadjuvant setting, are relatively few. Methods: Patients treated with weekly paclitaxel–cisplatin-based chemotherapy after core-needle biopsy were included study. Real-time quantitative polymerase chain reaction assays performed to detect expression. Results:...
Transfer RNAs (tRNAs) impact the development and progression of various cancers, but how individual tRNAs are modulated during triple-negative breast cancer (TNBC) remains poorly understood. Here, we found that XPOT (Exportin-T), a nuclear export protein receptor tRNAs, is associated with poor prognosis in directly orchestrates subset subsequently promoting synthesis proliferation human TNBC cells. knockdown inhibited cell vitro, RNA-seq indicated involved completion cytokinesis...
Abstract Background Linc01436 is a novel long non-coding RNA which associated with tumor proliferation and progression, but its involvement in breast cancer development neoadjuvant chemotherapy (NAC) response has not been reported. Here, we aimed to explore the association between expression NAC as well their survival outcome patients, identify potential molecular mechanisms of involved cancer. Materials Methods Univariate multivariate logistic regression, ROC were used verify predictive...
Background: The expression and function of long noncoding RNA (lncRNA) LOC100505851 in breast cancer are still unknown.We aimed to examine the lncRNA adjacent tissues preliminarily explore its predictive value patients receiving neoadjuvant therapy (NAT).Methods: was tested by qRT-PCR.The correlation between clinicopathological factors as well pathological complete response (pCR) analyzed chi-squared test logistic regression, respectively.The online database Kaplan-Meier plotter (KM plotter)...
Abstract BackgroundAchieving pathologic complete response (pCR) because of neoadjuvant therapy has been correlated with long-term clinical benefit, however, luminal-like tumors achieve a lower rate pCR in comparison other subtypes. The Shanghai Pudong (SHPD) 002 trial compares chemotherapy concurrently or different estrogen deprivation separately premenopausal and postmenopausal patients locally advanced breast cancer. MethodsIn this prospective, multicentre, neoadjuvant, phase III trial,...
Breast cancer is the 3rd most common type of malignant tumor worldwide with high heterogeneity, frequent recurrence, and metastasis tendency. In this study, we aimed to demonstrate value extracellular matrix- (ECM-) related genes in breast patients. The overall expression ECM assessed a novel SC3 clustering method, patients were divided into two clusters diverse recurrence rate. We established Cox regression model identified NPPA as an independent prognostic marker. downregulated patients,...
Abstract Background Transfer RNAs (tRNAs) are transported to the cytoplasm participating in mRNA translation through carrying cognate aminoacyl amino acids ribosomes. Accumulating evidence shows that tRNAs play an important role development and progression of various cancers, including breast cancer. However, it is still poorly clarified whether how individual tRNA modulated triple negative cancer (TNBC) progression. Methods Clinical value XPOT was explored cohorts. TNBC cell lines with...
Supplemental material, Supplementary_Materials_-_description for Predictive and prognostic value of EPIC1 in patients with breast cancer receiving neoadjuvant chemotherapy by Yaqian Xu, Yan Wang, Chenwei Yuan, Xiaonan Sheng, Rui Sha, Huijuan Dai, Shan Zhang, Yaohui Yanping Lin, Liheng Zhou, Shuguang Jie Wenjin Yin Jinsong Lu Therapeutic Advances Medical Oncology