A5100771532- Bone Metabolism and Diseases
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Bone health and osteoporosis research
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Advanced Numerical Methods in Computational Mathematics
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- Numerical methods in engineering
- Breast Lesions and Carcinomas
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Caveolin-1 and cellular processes
- Differential Equations and Numerical Methods
- Phytoestrogen effects and research
- Intestinal Malrotation and Obstruction Disorders
- Cellular Mechanics and Interactions
- Phytochemical compounds biological activities
- Advanced Breast Cancer Therapies
- Ultrasound in Clinical Applications
- Genomics, phytochemicals, and oxidative stress
Fujian Medical University
2023-2024
Second Affiliated Hospital of Fujian Medical University
2023-2024
Fujian University of Traditional Chinese Medicine
2010-2024
Renji Hospital
2022-2024
Shanghai Jiao Tong University
2024
Hong Kong Polytechnic University
2024
Medpace (United States)
2023
Kunming Medical University
2023
Xuzhou University of Technology
2022
Shanghai Sixth People's Hospital
2012
Postmenopausal osteoporosis (PMOP) is a common disease that has decreased bone strength as its main symptom after menopause. Effective treatment for PMOP remains lacking, but traditional Chinese medicine some advantages in delaying loss. Jiangu granule prescription commonly used to treat PMOP. Previous studies have demonstrated efficacy, the mechanism of action uncharacterized.This study aims observe and discuss ameliorate loss OVX rats by regulating gut microbiota (GM)-short-chain fatty...
The aim of the present study was to examine dynamic expression matrix metalloproteinase (MMP)‑2, MMP‑9 and MMP‑13 in an ovariectomy (OVX)‑induced osteoporosis rat model. A total 80 Sprague‑Dawley female rats (age, 3 months) were randomly divided into OVX sham groups, with 40 each group. Rats group received surgery, while remaining ovariectomized. After 12, 16, 20 24 weeks, 10 from sacrificed, respectively. It observed that bone mineral density (BMD) trabecular area significantly lower as...
Abstract: The purpose of this study was to compare mammography and sonography, as well their combination, for detecting breast tumors in symptomatic patients. effects age hormonal status were also examined. From 1999 2007, 549 patients underwent 665 examination sessions (mammography ultrasound). Abnormalities deemed positive if biopsy findings revealed malignancy negative from or all screening examinations negative. On pathology, 246 lesions malignant 419 benign the sensitivity, specificity,...
Previous studies have demonstrated that pretreatment with electroacupuncture (EA) at the zusanli/ST36 and sanyinjiao/SP6 acupoints prevents ovariectomy‑induced osteoporosis in rats; however, therapeutic effects of EA governor vessel (GV) bladder meridian (BL) remain unclear. In present study, GV4, GV6, BL20 BL23 on bones ovariectomized (OVX) rats were investigated to identify pathways mediate action bones. A postmenopausal model was established by performing an ovariectomy six‑month‑old...
When fibroblasts contract collagen matrices, the cells activate a Ca(2+)-dependent cyclic AMP signaling pathway. We have found that contraction also stimulates uptake of fluorescein isothiocyanate-dextran molecules from medium. Our results indicate enters directly into cell cytoplasm through 3- to 5-nm plasma membrane passages. These passages, which reseal in less than 5 s presence divalent cations, are likely sites Ca2+ during and first step contraction-activated signaling. The formation...
The objective of the present study was to identify chemical constituents volatile oil from Pyrolae herba (PHVO) and evaluate antiproliferative activity PHVO against SW1353 human chondrosarcoma cells. prepared by hydrodistillation characterized gas chromatography-mass spectroscopy (GC-MS). A total 12 components in were identified representing 81.62% integrated chromatographic peaks. major compounds found be n-hexadecanoic acid (29.29%), cedrol (17.08%), 6,10,14-trimethyl-2-pentadecanone...
The pathogenic mechanisms of postmenopausal osteoporosis (PMOP) development are complex and related to multiple cellular signalling transduction pathways. aim this study was compare the effects electroacupuncture (EA) at GV4/GV6 versus BL20/BL23 on bones in ovariectomised (OVX) rats explore pathways that mediate EA bone.Forty female Sprague-Dawley were allocated one four groups (n=10 each) received sham surgery (Sham group), OVX only (OVX plus (GV group) (BL group). Bone turnover markers...
Acute lung injury (ALI) has a complicated etiology that involves oxidative stress and inflammation. The role of lncRNACox2 (lincCOX2) in ALI regulation remains unclear. In this study, the model mice MLE-12 cell was induced by LPS. To investigate expression these models, we employed nanomagnetic bead-based RNA extraction method for quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis. This enabled us to determine levels evaluate knockdown efficiency. Moreover, also...
Abstract Background MicroRNA-1 (miR-1) is a tumour suppressor that can inhibit cell proliferation and invasion in several cancer types. In addition, miR-1 was found to be associated with drug sensitivity. Circulating miRNAs have been proven potential biomarkers predictive prognostic value. However, studies of expression the serum breast (BC) patients are relatively scarce, especially receiving neoadjuvant chemotherapy (NAC). Methods Serum samples from 80 were collected before chemotherapy,...
Senile osteoporosis (SOP) is a common disease that has decreased bone strength as its main symptom. There currently no medication can treat SOP, and traditional Chinese medicine advantages in slowing down aging. The present study aimed to observe the effects of Qing’e decoction on leptin, leptin receptor, sex hormone, biochemical markers metabolism naturally aging rats explore mechanism regulating metabolism. results revealed that, with increase age, mineral density (BMD), strength,...
Postmenopausal osteoporosis (PMOP) is characterized by increased bone loss due to enhanced osteoclastogenesis and resorption. A Chinese herbal formula, jiangugranule (JG), exhibited great efficacy in the clinical treatment of PMOP. However, molecular mechanisms underlying therapeutic effects remain unclear. The present study aimed examine JG‑containing serum on receptor activator nuclear factor‑κB (NF‑κB) ligand (RANKL)‑induced osteoclastogenesis. Osteoclast precursor RAW264.7 cells were...
<div>AbstractPurpose:<p>Despite accumulating evidence on dual blockade of HER2 for locally advanced HER2-positive breast cancer, no robust supports the addition pyrotinib to trastuzumab in neoadjuvant setting. The NeoATP trial aimed evaluate efficacy and safety with chemotherapy.</p>Patients Methods:<p>The phase II included female patients histologically confirmed stage IIA IIIC primary invasive cancer. Eligible received weekly paclitaxel–cisplatin chemotherapy four...
Abstract BackgroundAchieving pathologic complete response (pCR) because of neoadjuvant therapy has been correlated with long-term clinical benefit, however, luminal-like tumors achieve a lower rate pCR in comparison other subtypes. The Shanghai Pudong (SHPD) 002 trial compares chemotherapy concurrently or different estrogen deprivation separately premenopausal and postmenopausal patients locally advanced breast cancer. MethodsIn this prospective, multicentre, neoadjuvant, phase III trial,...
In this paper, we introduce new stable mixed finite elements of any order on polytopal mesh for solving second elliptic problem. We establish optimal error estimates velocity and super convergence pressure. Numerical experiments are conducted our different orders 2D 3D spaces that confirm the theory.
This study aimed to assess the associations of telomerase reverse transcriptase (TERT) and estrogen receptor-α (ERα) levels with bone mineral density in Chinese men women. Cancellous samples were obtained from femoral neck fracture osteoarthritis patients. BMD was evaluated by X-ray absorptiometry. Serum markers, including osteocalcin (BGP), tartrate-resistant acid phosphatase 5b (TRACP5b), estradiol (E2) testosterone (T), measured ELISA. Real-time PCR Western blot used hTERT, ERα, human...