A5100603283- MicroRNA in disease regulation
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Nuclear Structure and Function
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Electrochemical Analysis and Applications
- Gut microbiota and health
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Liver physiology and pathology
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- FOXO transcription factor regulation
- Biological Activity of Diterpenoids and Biflavonoids
- Nanocluster Synthesis and Applications
- Galectins and Cancer Biology
- RNA modifications and cancer
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2013-2024
Guangxi Normal University
2023-2024
Third People's Hospital of Yunnan Province
2015-2024
Affiliated Hospital of Nantong University
2023
Nantong University
2016-2023
Xi'an Jiaotong University
2018-2023
Zhujiang Hospital
2022
Southern Medical University
2022
Nanjing Medical University
2022
BACKGROUND: It has been shown that circular RNA (circRNA) is associated with human cancers, however, few studies have reported in hepatocellular carcinoma (HCC).OBJECTIVE: To estimate clinical values of a RNA, Hsa_circ_0001649, HCC.METHODS: Expression level hsa_circ_0001649 was detected HCC and paired adjacent liver tissues by real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs).Differences expression were analyzed using the t-test.Tests performed between...
// Fengming Zhu 1 , Octavia L. S. Chong Lee Shin Guangchang Pei Zhizhi Hu Juan Yang Han Meng Wang Jingyi Mou Jie Sun Yuxi Qian Zhi Zhao Huzi Xu Hui Gao 2 Weiqi Yao 3 Xiao Luo 4 Wenhui Liao 5 Gang Rui Zeng and Ying Division of Nephrology, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan 430030, Hubei, China Department Clinical Nutrition, Institute Biotechnology, Guanggu Biolake, 430000, Plastic Surgery, Geriatrics, Correspondence to: Yao, email:...
Circular RNAs (circRNAs) are a family of novel non-coding associated with various diseases, especially cancer. Recent studies have demonstrated that circRNAs participate in pathogenesis mainly by acting as microRNA (miRNA) sponges. The expression profile acute myeloid leukemia (AML) has rarely been reported.Profiles were analyzed using an Arraystar human circRNA microarray 5 bone marrow samples from patients newly diagnosed AML and iron-deficiency anemia. Quantitative reverse transcription...
Postmenopausal osteoporosis (PMOP) is a common disease that has decreased bone strength as its main symptom after menopause. Effective treatment for PMOP remains lacking, but traditional Chinese medicine some advantages in delaying loss. Jiangu granule prescription commonly used to treat PMOP. Previous studies have demonstrated efficacy, the mechanism of action uncharacterized.This study aims observe and discuss ameliorate loss OVX rats by regulating gut microbiota (GM)-short-chain fatty...
Excess mesangial extracellular matrix (ECM) and cell proliferation is the major pathologic feature of diabetic nephropathy (DN). Fenofibrate, a PPARα agonist, has been shown to attenuate formation in nephropathy. However, mechanisms underlying this effect remain be elucidated. In study, fenofibrate on high-glucose induced exertion its were investigated cultured rat cells by methylthiazoletetrazolium (MTT) assay, flow cytometry western blot. The results showed that treatment (MCs) with...
Rationale: Capillaries are composed of endothelial cells and the surrounding mural cells, pericytes. Microvascular repair after injury involves not only proliferation but also pericyte-based vessel stabilization. Exogenous bone marrow derived-putative progenitor (b-pEPCs) have potential for vascular repair; however, their effect on structure stabilization pericyte-related pathobiological outcomes in injured kidney has been fully examined. Methods: We applied ischemia-reperfusion (IR) to...
Biliverdin reductase A is an enzyme, with serine/threonine/tyrosine kinase activation, converting biliverdin (BV) to bilirubin (BR) in heme degradation pathway. It has been reported have anti-inflammatory and antioxidant effect monocytes human glioblastoma. However, the function of BVRA polarized macrophage was unknown. This study aimed investigate on activation polarization injured renal microenvironment. Classically activated macrophages (M1macrophages) alternative (M2 macrophages) murine...
N6-methyladenosine (m6A) methylation participates in the progression of bladder cancer (BCa). Nevertheless, regulatory mechanism alpha-ketoglutarate-dependent dioxygenase FTO influencing BCa has still remained elusive. In this study, to investigate tumor-suppressive effects via m6A RNA on patients, a total 15 tissues and adjacent normal (ANTs) were collected from patients who received tumor resection our hospital September 2015 December 2019. We found that expression was significantly...
Liver cancer, specifically hepatocellular carcinoma has been a widespread problem among general population. This study aims to investigate the modulating mechanism of gambogenic acid, phenolic xanthonoid, in diethylnitrosamine (DEN)-induced liver cancer rats. Male Wistar albino rats were clustered into four groups (n = 6). Group I served as control treated with normal saline. Hepatocellular carcinogenesis was induced by single intraperitoneal (i.p.) administration DEN saline (200 mg/kg b.w.)...
Background and Objectives: Connexin 43 (Cx43) is involved in the transfer of small signaling molecules between neighboring cells, thereby exerting a major influence on initiation progression tumorigenesis. However, there lack systematic research Cx43 expression its predictive role clinical diagnosis prognosis pan-cancer. Materials Methods: Several biological databases were used to evaluate levels GJA1 (encoding Cx43) diagnostic prognostic significance We targeted kidney renal clear cell...
Bifunctional RNAs that possess both protein-coding and noncoding functional properties were less explored poorly understood. Here we systematically the characteristics functions of such human bifunctional by integrating tandem mass spectrometry RNA-seq data. We first constructed a pipeline to identify annotate RNAs, leading characterization 132 high-confidence RNAs. Our analyses indicate may be involved in embryonic development can diverse tissues. Moreover, could interact with multiple...
Diabetes osteoporosis is a chronic complication of diabetes mellitus (DM) and associated with osteoclast formation enhanced bone resorption. Specnuezhenide (SPN) an active compound anti-inflammatory immunomodulatory properties. However, the roles SPN in diabetic remain unknown. In this study, primary marrow macrophages (BMMs) were pretreated stimulated receptor activator nuclear factor kappa B ligand (RANKL; 50 ng/mL) to induce osteoclastogenesis. The number osteoclasts was detected by...
DEK is a protein ubiquitously expressed in multicellular organisms as well certain unicellular organisms. It associated with the regulation of cell proliferation, differentiation, migration, apoptosis, senescence, self-renewal and DNA repairing. In tumor cells it carcinogenesis process, however there have been few previous studies into expression lung cancer. present study level mRNA was detected cancer tissues non-cancerous counterparts by performing reverse transcription-quantitative...