A5017130058- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Emergency and Acute Care Studies
- Peroxisome Proliferator-Activated Receptors
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Lymphatic System and Diseases
- Diet, Metabolism, and Disease
- Urban Agriculture and Sustainability
- ATP Synthase and ATPases Research
- GDF15 and Related Biomarkers
- MicroRNA in disease regulation
- Urban Green Space and Health
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
Tianjin Medical University
2022-2025
Second Hospital of Tianjin Medical University
2022-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
First Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Tianjin People's Hospital
2022-2024
Qingdao Eighth People's Hospital
2024
Guangdong Province Environmental Monitoring Center
2024
Affiliated Hospital of Southwest Medical University
2021-2023
BACKGROUND: It has been shown that circular RNA (circRNA) is associated with human cancers, however, few studies have reported in hepatocellular carcinoma (HCC).OBJECTIVE: To estimate clinical values of a RNA, Hsa_circ_0001649, HCC.METHODS: Expression level hsa_circ_0001649 was detected HCC and paired adjacent liver tissues by real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs).Differences expression were analyzed using the t-test.Tests performed between...
Chemoresistance in breast cancer has been of great interest past studies.However, the development rational therapeutic strategies targeting chemoresistant cells is still a challenge clinical oncology.By integrating data from global differences gene expression and phospho-receptor tyrosine kinases between sensitive parental (MCF-7) doxorubicin-resistant (MCF-7/ADR), we identified Axl as potential target for chemoresistance metastasis multidrug resistant cells.We analyzed 57 cell lines...
Peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1α (PGC1α) is a key regulator of mitochondrial biogenesis and respiration. PGC1α involved in the carcinogenesis, progression, metabolic state cancer. However, its role progression hepatocellular carcinoma (HCC) remains unclear.In this study, we observed that was down-regulated human HCC. A clinical study showed low levels expression were correlated with poor survival, vascular invasion, larger tumor size. inhibited...
Abstract Kynurenine 3-monooxygenase (KMO) is a pivotal enzyme in the kynurenine pathway of tryptophan degradation and plays critical role Huntington’s Alzheimer’s diseases. This study aimed to examine expression KMO human hepatocellular carcinoma (HCC) investigate relationship between its prognosis HCC patients. We first analyzed 120 paired samples (HCC tissues vs matched adjacent non-cancerous liver tissues) 205 clinical specimens using immunohistochemistry (IHC). Kaplan-Meier survival Cox...
To investigate the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on efficacy immune checkpoint inhibitor (ICI)-based therapy in patients with chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC).
Burns are a serious public health problem. Despite the decline in global burden of burns, burns remains high low- and middle-income regions, including BRICS countries. To analyse trend burn injury incidence countries (Brazil, Russia, India, China, South Africa) from 1990 to 2019 provide reference basis for prevention management. Data were obtained Global Burden Disease data, an age‒period‒cohort model was used data via apc package R 4.3.0 software. The injuries decreased 2019, 114.50 85.90...
Background and Aims: Hepatocellular carcinoma (HCC) poses a significant global health burden, with hepatitis B virus (HBV) being the predominant etiology in China. However, current diagnostic markers lack requisite sensitivity specificity. This study aims to develop validate serum N-glycomics-based models for diagnosis prognosis of HCC patients chronic (CHB)-related cirrhosis. Approach Results: enrolled total 397 CHB-related cirrhosis clinical management. N-glycomics profiling was conducted...
Heat shock protein 27 (Hsp27) is an ATP-independent molecular chaperone and confers survival advantages resistance to cancer cells under stress conditions. The effects mechanisms of Hsp27 in HCC invasion metastasis are still unclear. In this study, hepatocellular carcinoma (HCC) tissue array (n = 167) was used investigate the expression prognostic relevance patients. patients with high exhibited poor prognosis. Overexpression led forced cells, whereas silencing attenuated vitro vivo. We...
The aims of the study were to describe sleep quality among community-dwelling older people; determine association between (total and multidimensional), frailty overall health; as a mediator in health.This longitudinal, correlative used data from 2020 2022.A total 181 people city Southeast China assessed twice. Sleep was measured using Pittsburgh Quality Index at Time 1 (year 2020); FRAIL scale, health EuroQol visual analogue scale 2 (1 year later). Associations indirect effects examined...
Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased down-regulation ASS1 closely correlated with prognosis in patients. DNA methylation led to HCC. Stable silencing promoted migration invasion cells, whereas overexpression ASS1-inhibited cells vivo vitro. We also revealed...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a new nomenclature proposed in 2023. We aimed to compare the diagnostic efficacy of noninvasive tests (NITs) for advanced fibrosis under different nomenclatures patients with chronic hepatitis B (CHB). A total 844 diagnosed CHB and concurrent (SLD) by biopsy were retrospectively enrolled divided into four groups. The performances fibrosis-4 (FIB-4), gamma-glutamyl transpeptidase platelet ratio index (GPRI), aspartate...
// Qin Luo 1, * , Yurong Zhang Ning Wang 1 Guangzhi Jin 2 Haojie Dishui Gu Xuemei Tao Xisong Huo Tianxiang Ge Wenming Cong Cun Wenxin State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School Medicine, Shanghai, China Department Pathology, Eastern Hepatobiliary Surgery Second Military Medical University, These authors contribute equally to this work Correspondence to: Qin, e-mail: wxqin@sjtu.edu.cn Wang, cwang@shsci.org...
Emerging evidence suggests that butyrate, a short-chain fatty acid, may have beneficial effects on obesity and its associated metabolic comorbidities, but the related molecular mechanism is largely unknown. This study aims to investigate role of butyrate in diet-induced disorders relevant regulatory mechanisms. Here, dietary supplementation with Sodium (NaB) was carried out mice fed high-fat diet (HFD) or chow diet. At week 14, HFD displayed an obese phenotype down-regulated expression...
Microsporidia are a group of obligate intracellular parasites causing significant disease in human beings and economically important animals. Though few spore wall proteins (SWPs) have now been identified these intriguing species, the information on SWPs remains too little to elucidate formation mechanisms microsporidia. It has well described that numerous with tandem repeats tend be localized cell fungi parasites. Previously, by scanning microsporidian Nosema bombycis, we obtained 83...
The post-operative complication of chylous leakage after breast cancer is relatively rare, and few clinical studies have been published. We report a 64-year-old woman with following modified radical mastectomy. describe the patient’s diagnostic treatment process in detail. patient was diagnosed grade II (left) invasive ductal carcinoma. Post-operatively, patient's chest wall axilla were pressurized, negative pressure drainage initiated. On fifth day, from increased significantly, developed...
Patients with chronic hepatitis B virus infection (CBI) concurrent nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common in clinical practice, and it quite important to identify the etiology when occurs. A noninvasive diagnostic model was constructed patients who need antihepatitis (HBV) therapies [histologic activity index (HAI) ≥ 4] CBI NAFLD by analyzing routine parameters.In total, 303 out of 502 proven biopsy from January 2017 December 2020 Tianjin Second People's...
Pneumonia remains the leading cause of death among children aged 1-59 months. The early prediction poor outcomes (PO) is critical concern. This study aimed to explore risk factors relating PO in severe community-acquired pneumonia (SCAP) and build a PO-predictive nomogram model for with SCAP.We retrospectively identified 300 Chinese pediatric patients diagnosed SCAP who were hospitalized Affiliated Hospital Southwest Medical University from August 1, 2018, October 31, 2021. Children divided...
Abstract Background and aims: Hepatitis C virus (HCV) associated cirrhosis are in high risk of hepatocellular carcinoma (HCC), this study aimed to explore the factors, establish validate a novel nomogram. Methods: A total 309 inpatients with HCV- from Tianjin Second People's Hospital were selected as training cohort, 363 patients Beijing You’an validation cohort. Both cohorts received Direct-Acting Antiviral Agents (DAAs) treatment achieved sustained virological response (SVR). Laboratory...
BACKGROUND Direct-acting antivirals (DAAs) revolutionized the treatment of chronic hepatitis C virus (HCV)-associated disease achieving high rates sustained virological response (SVR). However, whether DAAs can reduce occurrence hepatocellular carcinoma (HCC) in patients with HCV-associated cirrhosis who are at risk have not been concluded. AIM To investigate effect on HCC after SVR. METHODS Of 427 inpatients were enrolled Tianjin Second People's Hospital from January 2014 to April 2020. 118...
BACKGROUND The development of laparoscopic technology has provided a new choice for surgery gastric cancer (GC), but the advantages and disadvantages total gastrectomy (LTG) laparoscopic-assisted (LATG) in treatment effect safety are still controversial. purpose this study is to compare efficacy two methods GC, provide basis clinical decision-making. AIM To totally LTG (TLTG) LATG context radical GC. Additionally, we investigated feasibility esophagojejunostomy technique. METHODS Literature...