A5044408079- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- MicroRNA in disease regulation
- Phytochemistry and Biological Activities
- COVID-19 epidemiological studies
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Adipokines, Inflammation, and Metabolic Diseases
- Forensic Entomology and Diptera Studies
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Outbreaks Research
- Traditional Chinese Medicine Analysis
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Extracellular vesicles in disease
- Phytochemical Studies and Bioactivities
- Flavonoids in Medical Research
- Liver Disease Diagnosis and Treatment
Southwest Medical University
2020-2025
Affiliated Hospital of Southwest Medical University
2020-2024
Nanjing University
2020-2022
First Affiliated Hospital of Sichuan Medical University
2021-2022
China Pharmaceutical University
2021
Universidade de Vigo
2021
Weatherford College
2021
Chinese University of Hong Kong
2021
State Key Laboratory of Pharmaceutical Biotechnology
2020
Pharmaceutical Biotechnology (Czechia)
2020
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is hopeful target for therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was performed to explore the role in all cell types microenvironment (TME) from murine MC38 xenografts. Intratumoral cells were found be functionally heterogeneous responded significantly SHP099, allosteric...
Background: Longan is the fruit of Dimocarpus longan Lour. and arillus has long been used in traditional Chinese medicine possessing various health benefits. However, excessive intake found daily life to cause “ shanghuo ” syndrome. Shanghuo linked increased disease susceptibility. The present study thus aimed investigate toxicological outcomes after treatment. Methods: extract at a normal dosage 4 g/kg two excess dosages 8 16 was orally administered C57BL/6J mice for weeks or with...
Abstract M1 macrophages secrete a large number of proinflammatory factors and promote the expansion atherosclerotic plaques processes. Salvianolic acid B (Sal B) exerts anti-inflammatory, antitumor other effects, but no study has addressed whether Sal can regulate polarization to exert these anti-atherosclerotic effects. Therefore, we investigated inhibition in macrophage underlying mechanism. The effects different treatments on cell viability, gene expression secretion related proteins,...
Summary Since the 1980s, China has been criticized for its mode of chronic disease management (CDM) that passively provides treatment in secondary and tertiary hospitals but lacks active prevention community health centers (CHCs). there are few systematic evaluations CHCs' methods CDM, this study aimed to analyze their abilities. On macroperspective, we searched literature China's largest most authoritative databases official websites departments. Literature was used government's efforts...
Lung cancer is a malignant tumor with high incidence in China, especially non-small cell lung (NSCLC), which the main threat to human life, terrible morbidity and mortality. The research on treatment mechanism of NSCLC has been forefront hotspot research. Recent patents show that alpha-solanine (α-solanine) exhibits best anti-cancer activity, although its target related remain be elucidated.This study aims explore possible targets mechanisms α-solanine through network pharmacology...
Abstract The novel coronavirus disease 2019 (COVID-19) epidemic, which was first identified in Wuhan, China December 2019, has rapidly spread all over and across the world. By end of February 2020, epidemic outside Hubei province been well controlled, yet next wave transmission other countries may have just begun. A retrospective modeling dynamics would provide insights into epidemiological characteristics evaluation effectiveness strict measures that taken by central local governments...
A nationwide campaign for rational proton pump inhibitor (PPI) use launched in 2015 had a positive impact hospitalized patients PPI use. But there were few studies focusing on the of PPIs outpatients. In 2018, management committee conducted year-long intervention appropriate outpatient and emergency departments, including clinical pharmacist interventions stewardship interventions. The purpose this study was to examine committee's multifaceted by comparing real-world acid suppressant...
Gas chromatography-mass spectrometry method was developed for the qualitative and quantitative analyses of chlorpyrifos in human blood samples. The parathion (internal standard) were extracted with a mixed solvent hexane acetonitrile. Chlorpyrifos well separated from internal standard. linear range 0.01–2 μ g/ml blood. limit detection quantification estimated at 0.002 0.01 g/ml, respectively. inter- intra-day precisions, accuracy, recovery assessed to verify this method. results showed that...
To explore the role and mechanism of BKCa in diabetic kidney disease.Rat mesangial cells (MCs) HBZY-1 were cultured with high glucose to simulate high-glucose environment disease vivo. The effects large conductance calcium-activated potassium channel (BKCa) on proliferation, migration, apoptosis observed. contents transforming growth factor beta 1 (TGF-β1), Smad2/3, collagen IV (Col IV), fibronectin (FN) extracellular matrix also observed.High significantly damaged cells, which enhanced...
Objective: The aim of this study was to examine the effect berberine on diabetes mellitus in vivo and vitro, elucidate underlying mechanisms. Methods: Rat models type 2 (T2DM) were established treated with berberine. Pathological changes thoracic aorta, inflammatory factor adiponectin levels investigated. Vascular smooth muscle cells (VSMCs) aorta cultured Cellular proliferation, migration, Responses vascular rings phenylephrine (PE) sodium nitroprusside (SNP) after intervention relaxation...