A5017830037- Ion Transport and Channel Regulation
- Photodynamic Therapy Research Studies
- Ion channel regulation and function
- Cervical Cancer and HPV Research
- Nitric Oxide and Endothelin Effects
- Colorectal and Anal Carcinomas
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Anorectal Disease Treatments and Outcomes
- Gut microbiota and health
- S100 Proteins and Annexins
- Food composition and properties
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Heat shock proteins research
- Immune cells in cancer
- Traditional Chinese Medicine Studies
- Berberine and alkaloids research
- Alkaline Phosphatase Research Studies
- Thermal Regulation in Medicine
- Thyroid Disorders and Treatments
Nantong University
2021-2024
Southwest Medical University
2010-2024
Chongqing Medical University
2024
Yibin University
2024
Children's Hospital of Chongqing Medical University
2024
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Zhejiang University
2012-2021
First Affiliated Hospital Zhejiang University
2007-2021
Harbin Medical University
2011-2019
Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory of the gastrointestinal tract, which has high recurrence rate and incurable due to lack effective treatment. Mesenchymal stromal cells (MSCs) are class pluripotent stem that have recently received lot attention their strong self-renewal ability immunomodulatory effects, large number experimental clinical models confirmed positive therapeutic effect MSCs on IBD. In preclinical studies, MSC treatment for IBD relies paracrine...
Abstract Low‐dose 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) has been used to cope with skin photoaging, and is thought involve DNA damage repair responses. However, it still unknown how low‐dose ALA‐PDT regulates curb photoaging. We established a photoaging model using human dermal fibroblasts (HDFs) rat skin. RNA‐sequencing (RNA‐seq) analysis was conducted identify differentially expressed genes (DEGs) in HDFs before after treatment, followed by bioinformatics analysis....
Background Proprioception plays an important role in knee movements. Since there are controversies surrounding the overall recovery time of proprioception following surgery, it is necessary to define factors affecting proprioceptive after anterior cruciate ligament (ACL) reconstruction and investigate relationship between muscle strength. Methods A total 36 patients who had their ACL reconstructed with a semitendinosus/gracilis graft (reconstructed group: 6 months post-surgery) 13 healthy...
Stimulation of BK2R (bradykinin [BK] B2 receptor) has been shown to increase renal Na + excretion. The aim the present study is explore role in regulating Kir4.1 and NCC (NaCl cotransporter) distal convoluted tubule (DCT). Immunohistochemical studies demonstrated that was highly expressed both apical lateral membrane Kir4.1-positive tubules, such as DCT. Patch-clamp experiments BK inhibited basolateral 40-pS K channel (a Kir4.1/5.1 heterotetramer) DCT, this effect blocked by antagonist but...
The stimulation of β-adrenergic receptor increases thiazide-sensitive NaCl cotransporter (NCC), an effect contributing to salt-sensitive hypertension by sympathetic stimulation. We now test whether the receptor-induced activation NCC is achieved through activating basolateral Kir4.1 in distal convoluted tubule (DCT). Application norepinephrine increased 40 pS K
Voriconazole is the therapy of choice for aspergillosis. However, hepatotoxicity most common reason discontinuation voriconazole. In contrast, posaconazole well tolerated, with a low incidence hepatotoxicity. cases, associated high voriconazole trough concentration influenced mainly by cytochrome P450 (CYP) 2C19 gene polymorphism. Compared normal metabolizers, intermediate and poor metabolizers generally have higher concentrations an increased risk Here, we describe changes in throughout...
Anal condyloma acuminatum (CA) is marked by its thorny treatment and high recurrence rate. Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates significant efficacy safety in treating anal CA, it does not completely prevent recurrence. This study aimed to develop validate a nomogram model predicting the risk of relapse HIV-negative patients with CA following ALA-PDT. A retrospective analysis was conducted on diagnosed who received combined CO2 laser vaporization ALA-PDT...
Objective: This study examined the lymphocyte infiltration induced by neural stem cell grafts in traumatized brain.Methods: Sixty Sprague-Dawley rats were assigned randomly to transplantation (n = 30) or control groups, and each rat was subjected brain contusion. The cells derived from Wistar transplanted into lesion of group, saline injected instead controls. Local studied using haematoxylin eosin staining, immunohistochemistry flow cytometry. immunogenicity evaluated MHC-I...
The basolateral 50-pS K channels are stimulated by a cAMP-dependent pathway and inhibited cytochrome P-450-omega-hydroxylase-dependent metabolism of arachidonic acid (AA) in the rat thick ascending limb (TAL). We now used patch-clamp technique to examine whether stimulation adenosine A(₂a) receptor modulates inhibitory effect AA on medullary TAL. Stimulation with CGS-21680 or inhibition phospholipase A₂ (PLA₂) AACOCF3 increased channel activity Western blot demonstrated that application...
Objective: The aim of this study was to examine the effect berberine on diabetes mellitus in vivo and vitro, elucidate underlying mechanisms. Methods: Rat models type 2 (T2DM) were established treated with berberine. Pathological changes thoracic aorta, inflammatory factor adiponectin levels investigated. Vascular smooth muscle cells (VSMCs) aorta cultured Cellular proliferation, migration, Responses vascular rings phenylephrine (PE) sodium nitroprusside (SNP) after intervention relaxation...
Condyloma acuminatum (CA) is a sexually transmitted disease caused by human papillomavirus (HPV) often with high recurrence rate after treatment. This study aimed to construct and evaluate nomogram model containing three clinical parameters predict the risk of CA 5-aminolevulinic acid photodynamic therapy (ALA-PDT). A predictive was established based on training cohort 346 patients treated ALA-PDT between January 2013 July 2018. validation 123 recruited from August 2018 December 2019. The...
The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. water content tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, then gradually decreased. After treatment with the competitive antagonist 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, tissues decreased between 12-72 hours neurological behaviors improved 2 weeks. These experimental findings...
Abstract Background Few studies have reported postoperative relapse of condyloma acuminatum (CA) after 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) in human immunodeficiency virus (HIV) positive patients. Methods The clinical data HIV‐positive CA patients treated with ALA‐PDT from October 2018 to December 2019 were analyzed retrospectively. Univariate and multivariate Cox regression was used analyze the variables related recurrence. Pearson correlation test employed between CD4 + T...
Keratinocytes, located in the outermost layer of human skin, are pivotal cells to resist environmental damage. Cellular autophagy plays a critical role eliminating damaged organelles and maintaining skin cell homeostasis. Low-dose 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been demonstrated enhance skin's antistress ability; however, regulatory mechanisms keratinocytes remain unclear. In this study, we treated immortalized (HaCaT cells) with low-dose ALA-PDT (0.5 mmol/L, 3 J/cm
Background: Anal condyloma acuminatum (CA) is marked by its thorny treatment and high recurrence rate. Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates significant efficacy safety in treating anal CA, it does not completely prevent recurrence. This study aimed to develop validate a nomogram model predicting the risk of relapse HIV-negative patients with CA following ALA-PDT.Methods: A retrospective analysis was conducted on diagnosed who received combined CO2 laser...
Abstract Background Transient symptomatic zinc deficiency (TSZD), an acquired type of deficiency, is a rare, but probably underrecognized disease, extremely in breastfed premature with low birthweight infants. Its clinical manefestations are similar to Acrodermatitis enteropathica (AE), which genetic absorption disorder caused by SLC39A4 gene mutations. This encodes member the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded localizes cell membranes and required for...