A5100703567- Head and Neck Cancer Studies
- Photodynamic Therapy Research Studies
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Acute Myocardial Infarction Research
- Autophagy in Disease and Therapy
- Advanced MRI Techniques and Applications
- Anorectal Disease Treatments and Outcomes
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Immunotherapy and Immune Responses
- Cardiac electrophysiology and arrhythmias
- Cytomegalovirus and herpesvirus research
- Skin Protection and Aging
- Immune Cell Function and Interaction
- Heme Oxygenase-1 and Carbon Monoxide
- Hippo pathway signaling and YAP/TAZ
- Macrophage Migration Inhibitory Factor
- Cancer, Hypoxia, and Metabolism
- melanin and skin pigmentation
- Polyomavirus and related diseases
- Advanced Electrical Measurement Techniques
Nanjing Jiangning Hospital
2023-2024
Nantong University
2021-2024
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Nanjing Medical University
2021
Huizhou Central People's Hospital
2021
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Sun Yat-sen University Cancer Center
2016-2019
Abstract Chronic inflammation plays an important role in tumor progression. The aim of this analysis was to evaluate whether inflammatory biomarkers such as the Glasgow prognostic score (GPS), neutrophil‐lymphocyte ratio (NLR), platelet‐lymphocyte (PLR), and lymphocyte‐monocyte (LMR) could predict prognosis nasopharyngeal carcinoma (NPC). In analysis, pretreatment GPS, NLR, PLR, LMR 388 patients who were diagnosed nonmetastatic NPC recruited prospectively 863 Program No. 2006AA02Z4B4...
Abstract Low‐dose 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) has been used to cope with skin photoaging, and is thought involve DNA damage repair responses. However, it still unknown how low‐dose ALA‐PDT regulates curb photoaging. We established a photoaging model using human dermal fibroblasts (HDFs) rat skin. RNA‐sequencing (RNA‐seq) analysis was conducted identify differentially expressed genes (DEGs) in HDFs before after treatment, followed by bioinformatics analysis....
This study aims to investigate the feasibility of contouring target volume according residual tumor and decreasing dose regression field after induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (NPC).From August 2009 2013, patients with stage III-IVB NPC were treated IC concurrent chemoradiotherapy. Gross nasopharynx (GTVnx)-residual gross cervical lymph node (GTVnd)-residual contoured post-IC primary any N+ disease, respectively. The was included CTVnx1/CTVnd1...
Background: Fulminant myocarditis (FM) is associated with high mortality and an unfavorable long-term prognosis. However, noninvasive, rapid diagnostic monitoring methods for FM are lacking. Case summary: This report details the case of a patient diagnosed through comprehensive assessment involving typical clinical symptoms, laboratory analyses, echocardiographic evidence, cardiac magnetic resonance (CMR) findings. Before underwent CMR, optical pumped magnetometer magnetocardiography...
Abstract Background Colorectal cancer (CRC) is a prevalent malignancy with high mortality and morbidity rates. Although the significant efficacy of immunotherapy well established, it only beneficial for limited number individuals CRC. Methods Differentially expressed immune-related genes (DE-IRGs) were retrieved from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), ImmPort databases. A prognostic signature comprising DE-IRGs was developed using univariate, LASSO, multivariate...
Anal condyloma acuminatum (CA) is marked by its thorny treatment and high recurrence rate. Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates significant efficacy safety in treating anal CA, it does not completely prevent recurrence. This study aimed to develop validate a nomogram model predicting the risk of relapse HIV-negative patients with CA following ALA-PDT. A retrospective analysis was conducted on diagnosed who received combined CO2 laser vaporization ALA-PDT...
To develop and validate a clinical diagnostic model based on optical pumped magnetometer magnetocardiography (OPM-MCG) for the detection of myocardial ischaemia in patients with borderline coronary lesions prior to invasive angiography (ICA).
Magnetocardiography (MCG) is a novel non-invasive technique that detects subtle magnetic fields generated by cardiomyocyte electrical activity, offering sensitive detection of myocardial ischemia. This study aimed to assess the ability MCG predict impaired perfusion using single-photon emission computed tomography (SPECT).
Human fibroleukin 2 (Fgl2), a member of the fibrinogen superfamily, can cleave prothrombin to generate thrombin or is secreted in soluble form as new type effector Tregs with immunomodulatory functions. However, there little research on role Fgl2 cutaneous squamous cell carcinoma (CSCC) growth. We examined expression samples from CSCC patients and lines. Then, effect was evaluated vitro animals. Regulation autophagy by explored CSCC. Coimmunoprecipitation (Co-IP) immunofluorescence...
Condyloma acuminatum (CA) is a sexually transmitted disease caused by human papillomavirus (HPV) often with high recurrence rate after treatment. This study aimed to construct and evaluate nomogram model containing three clinical parameters predict the risk of CA 5-aminolevulinic acid photodynamic therapy (ALA-PDT). A predictive was established based on training cohort 346 patients treated ALA-PDT between January 2013 July 2018. validation 123 recruited from August 2018 December 2019. The...
As an adjuvant immunotherapy, cytokine-induced killer cells (CIKs) infusion has been demonstrated to exert potent effectiveness in several types of cancer patients who received curative treatment. However, controversy exists regarding whether nasopharyngeal carcinoma (NPC) can benefit from additional treatment after radical radiotherapy or chemoradiotherapy improve their distant control and survival. In this retrospective study, we aimed evaluate the efficacy CIK therapy NPC with stage...
Purpose: To identify the association between ABO blood type and survivals in nasopharyngeal carcinoma patients. Patients methods: We retrospectively analyzed 2439 consecutive non-metastasis patients January 2001 December 2004 at Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate multivariate analysis was performed by Cox regression model. Chi-square test to compare categorical variables. Results: In whole patients, with non-O (A, B,...
Purpose: Investigating surrogate endpoints shortening the time of therapeutic evaluation in nasopharyngeal carcinoma (NPC) after radical treatment. Patients and Methods: We retrospectively analyzed 830 patients receiving intensity-modulated radiotherapy (IMRT) from 2008 to 2010 being stratified by 8th edition UICC/AJCC staging system plasma Epstein-Barr virus DNA (EBV DNA). The annual rates overall survival (OS), progression-free (PFS), loco-regional recurrence-free (LRFS), distant...
Abstract Background Few studies have reported postoperative relapse of condyloma acuminatum (CA) after 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) in human immunodeficiency virus (HIV) positive patients. Methods The clinical data HIV‐positive CA patients treated with ALA‐PDT from October 2018 to December 2019 were analyzed retrospectively. Univariate and multivariate Cox regression was used analyze the variables related recurrence. Pearson correlation test employed between CD4 + T...
Background: Anal condyloma acuminatum (CA) is marked by its thorny treatment and high recurrence rate. Although 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrates significant efficacy safety in treating anal CA, it does not completely prevent recurrence. This study aimed to develop validate a nomogram model predicting the risk of relapse HIV-negative patients with CA following ALA-PDT.Methods: A retrospective analysis was conducted on diagnosed who received combined CO2 laser...
Ultrapulse fractional CO
Keratinocytes, located in the outermost layer of human skin, are pivotal cells to resist environmental damage. Cellular autophagy plays a critical role eliminating damaged organelles and maintaining skin cell homeostasis. Low-dose 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been demonstrated enhance skin's antistress ability; however, regulatory mechanisms keratinocytes remain unclear. In this study, we treated immortalized (HaCaT cells) with low-dose ALA-PDT (0.5 mmol/L, 3 J/cm
Whether hepatitis B virus (HBV) infection poses risk to patients with nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era remains unclear.953 non-metastatic, newly diagnosed NPC who received detection of serologic surface antigen (HBsAg) and treated IMRT were retrospectively reviewed. 171 had HBV (HBsAg seropositive). Propensity score matching method (PSM) stabilized inverse probability treatment weighting (IPTW) used address confounding. The survival rates...
<title>Abstract</title> Background Colorectal cancer (CRC) is a prevalent malignancy with high death and morbidity rates. Even though the significant efficacy of immunotherapy well-established, it only beneficial for limited number individuals CRC. Methods Differentially expressed immune-related genes (DE-IRGs) were retrieved from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Immport databases. prognostic signature comprising DE-IRGs was developed by means Univariate, Lasso,...
<div>Abstract<p>The clinical prognosis of pancreatic cancer remains rather disappointing despite tremendous efforts in exploring medical treatments the past two decades. Development more effective treatment strategies is still desperately needed to improve outcomes patients with cancer. SKLB261 a multikinase inhibitor obtained recently through lead optimization. In this investigation, we shall evaluate its anti–pancreatic effects both <i>in vitro</i> and...