A5100401958- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Pain Management and Opioid Use
- interferon and immune responses
- Anesthesia and Pain Management
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Growth Hormone and Insulin-like Growth Factors
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Diabetes and associated disorders
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Distributed and Parallel Computing Systems
- Distributed systems and fault tolerance
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Erythrocyte Function and Pathophysiology
- Cytomegalovirus and herpesvirus research
West China Hospital of Sichuan University
2025
Beijing YouAn Hospital
2015-2025
Capital Medical University
2015-2025
Sichuan University
2023-2025
Southwest Medical University
2024
First Affiliated Hospital of Sichuan Medical University
2024
Third Affiliated Hospital of Southern Medical University
2023-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Autoimmune hepatitis (AIH) is considered less common in the Asia Pacific region. Due to this, AIH flare as a cause of acute on chronic liver failure (ACLF) often overlooked and treatment delayed. We aimed at defining clinical histopathological spectrum role steroid therapy AIH-ACLF. Patients with AIH-ACLF, prospectively recruited followed between 2012 2017, were analyzed from Asian Association for Study Liver ACLF Research Consortium (AARC) data base. Diagnosis was confirmed using...
Abstract: Inflammatory bowel disease (IBD) is a chronic inflammatory of the gastrointestinal tract, which has high recurrence rate and incurable due to lack effective treatment. Mesenchymal stromal cells (MSCs) are class pluripotent stem that have recently received lot attention their strong self-renewal ability immunomodulatory effects, large number experimental clinical models confirmed positive therapeutic effect MSCs on IBD. In preclinical studies, MSC treatment for IBD relies paracrine...
Silibinin-phospholipid complex (SPC) has been utilized to treat acute liver injury clinically. Nevertheless, the hepatoprotective mechanism of SPC remains be further dissected in response new insights into pathogenesis injury. Very recently, we have documented, for first time, that M2-like macrophages exert hepatoprotection against insult through inhibiting necroptosis-S100A9-necroinflammation. In present work, integrated this finding action SPC, and attempted dissect from perspective.SPC...
Hepatitis B virus-related acute-on-chronic liver failure (AoCLF) is associated with a high mortality rate. Plasma exchange (PE) useful to bridge patients AoCLF transplantation or recovery. The aim of this study was analyze the impact model for end-stage disease (MELD) score on 30-day survival in treated PE conventional medications and evaluate therapeutic effectiveness PE. In study, 62 enrolled who received treatment were compared 131 medications. MELD scores calculated according original...
Alzheimer's disease (AD) is a most serious age-related neurodegenerative disorder accompanied with significant memory impairments in this world. Recently, microRNAs (miRNAs) have been reported to be invlolved the pathophysiology of AD. Previous studies shown that miRNA-206 (miR-206) implicated pathogenesis AD via suppressing expression brain-derived neurotrophic factor (BDNF) brain. Here, we examined miR-206-3p and miR-206-5p hippocampus cortex Abeta precursor protein (APP)/presenilin-1...
Background: This study aimed to investigate the trajectories of acute postoperative pain intensity during initial 5 days after abdominal surgery, and analyze their association with risk developing chronic postsurgical (CPSP). Methods: We enrolled patients elective surgery measurements taken across 1 through 5. Since is often unavoidable its closely related invasiveness focusing on overall trajectory may be more meaningful than evaluating at a single time point. Therefore, primary outcome...
Serverless platforms typically adopt an early-binding approach for function sizing, requiring developers to specify immutable size each within a workflow beforehand. Accounting potential runtime variability, must functions worst-case scenarios ensure service-level objectives (SLOs), resulting in significant resource inefficiency. To address this issue, we propose Janus, novel adaptation framework serverless platforms. Janus employs late-binding approach, allowing sizes be dynamically adapted...
Various methods, including the indocyanine green (ICG) clearance test, Child-Turcotte-Pugh score (CTP), model for end-stage liver disease (MELD), and MELD combined with serum sodium concentration (MELD-Na), have been used widely in function evaluation patients disease. In this study, we compared ability of these methods to predict mortality decompensated hepatitis B cirrhosis.A total 98 cirrhosis were included study followed up 12 months. The ICG-derived measurements (ICG-PDR, ICG-R15,...
Liver transplantation (LT) is an effective therapy for acute-on-chronic liver failure (ACLF) but limited by organ shortages. We aimed to identify appropriate score predicting the survival benefit of LT in HBV-related ACLF patients.Hospitalized patients with acute deterioration chronic disease (n = 4577) from Chinese Group on Study Severe Hepatitis B (COSSH) open cohort were enrolled evaluate performance five commonly used scores prognosis and transplant benefit. The rate was calculated...
Early recurrence within 1 year is the leading cause of early death in patients with hepatocellular carcinoma (HCC) after liver resection. Circulating levels insulin-like growth factor-1 (IGF-1) reflect function and prognosis HCC. In present study, we aimed to evaluate whether baseline dynamic changes serum IGF-1 were associated HCC who underwent resection.A total 144 resection included this study. other tumor-related indexes collected during perioperative period. Univariate multivariate...
Background and objective.The liver-specific functions of hepatocytes are improved by co-culturing with primary hepatic stellate cells (HSC).However, HSC have a short lifespan in vitro, which is considered major limitation for their use various applications.This study aimed to establish immortalized human using the simian virus 40 large T antigen (SV40LT) applications vitro.Methods.Primary were transfected recombinant retrovirus containing SV40LT.The characterized analyzing gene expression...
There is no study focusing on noninvasive predictors for the efficacy of sintilimab (anti-PD-1) plus IBI305 (a bevacizumab biosimilar) treatment in advanced hepatocellular carcinoma (HCC). A total 33 patients with HCC were prospectively enrolled and received from November 2018 to October 2019. Baseline characteristics including clinical data, laboratory tumor features based pretreatment CT/MR collected. Meanwhile, contrast-enhanced ultrasound (CEUS) target was performed quantitative...
The rapid clearance of hepatitis C virus induced by direct-acting antivirals (DAAs) affects natural killer (NK) cells, but the reported results are not consistent, and relative mechanism was unclear. This study focused on dynamic changes NK cells during after DAA treatment analyzed reasons.Peripheral blood from 35 chronic patients who were treated with DAAs collected at baseline weeks 1, 2, 4, 12, post-treatment week-12. frequency, subset, phenotype assayed flow cytometry. Lactate...
Acute-on-chronic liver failure (ACLF) is acute decompensation of function in the setting chronic disease, and characterized by high short-term mortality. In this study, we sought to investigate clinical course patients at specific time points, propose dynamic prognostic criteria.We assessed 453 with ACLF during a 12-week follow-up period retrospective multicenter study. The was defined as disease recovery, improvement, worsening or steady patterns based on variation tendency prothrombin...
Acute-on-chronic liver failure (ACLF) is divided into three types according to the underlying disease: non-cirrhosis (type A), compensated cirrhosis B) and decompensated C). However, whether chronic diseases impact ACLF prognosis not clear. The present study aimed compare characteristics outcomes of type A B hepatitis virus (HBV)-ACLF patients.According European Association for Study Liver-Chronic Liver Failure (EASL-CLIF) diagnostic criteria, 86 HBV-ACLF 71 were prospectively enrolled....
Abstract Background This study aimed to explore the efficacy of hookwire for computed tomography (CT)-guided pulmonary nodule (PN) localization before video-assisted thoracoscopic surgery (VATS) resection and determine risk factors localization-related complications. Methods We enrolled 193 patients who underwent preoperative CT-guided PN localization. The were categorized into groups A (103 had no complications) B (90 according CT VATS. Uni- multivariate logistic regression analyses used...