A5016286647- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- RNA modifications and cancer
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- Advanced Sensor and Energy Harvesting Materials
- Hepatitis C virus research
- Dielectric materials and actuators
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- Xenotransplantation and immune response
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Cancer-related gene regulation
- Bacterial biofilms and quorum sensing
- Innovative Energy Harvesting Technologies
- MicroRNA in disease regulation
- Thermal Regulation in Medicine
- Radiomics and Machine Learning in Medical Imaging
First Affiliated Hospital Zhejiang University
2010-2025
Zhejiang University
2012-2025
Zhejiang Cancer Hospital
2025
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2011-2024
National Clinical Research Center for Digestive Diseases
2024
Rutgers, The State University of New Jersey
2013-2018
Center for Innovation
2016
South China Institute of Collaborative Innovation
2015
University of Science and Technology of China
2009
Abstract Tryptophan (Trp) metabolism plays a crucial role in influencing the development of digestive system tumors. Dysregulation Trp and its metabolites has been identified various cancers, including esophageal, gastric, liver, colorectal, pancreatic cancers. Aberrantly expressed are associated with diverse clinical features Moreover, levels these can serve as prognostic indicators predictors recurrence risk patients exert their influence on tumor growth metastasis through multiple...
Immune-related genes (IRGs) have been identified as critical drivers of the initiation and progression hepatocellular carcinoma (HCC). This study is aimed at constructing an IRG signature for HCC validating its prognostic value in clinical application. The was developed by integrating multiple expression data sets from TCGA GEO databases. IRGs were then combined with features to validate robustness through bioinformatics tools. A total 1039 657 samples. Subsequently, subjected univariate Cox...
Background There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when treatment was administered more than 48 hours after symptom onset. Methods During in 2009, a cohort pH1N1 influenza built China, and their information collected systematically, analyzed Cox models. Results 920 adults 541 children didn't receive corticosteroids were analyzed. In-hospital mortality higher did not antiviral therapy (18.2%)...
ABSTRACT Introduction Standard treatments provide limited benefits for patients with intermediate‐ or advanced‐stage hepatocellular carcinoma (HCC). This retrospective observational study aimed to assess the potential improvements in outcomes associated systemic therapies receiving transarterial chemoembolization (TACE) initially unresectable HCC. Methods Between February 2019 and March 2023, we reviewed diagnosed intermediate‐to‐advanced HCC who were treated either TACE combined...
Knee osteoarthritis (KOA) is the leading cause of knee joint dysfunction. Manual therapy (MT) can decrease patients' levels pain and improve their functionality. But most traditional methods focus solely on or its surrounding tissues, neglecting impact waist, hip, ankle, lower limb alignment KOA. The objective to clarify effects five-step adjustment manipulation KOA, evaluate efficacy, explore new treatment approaches for manual KOA therapy. (1) 45 healthy volunteers will be recruited...
Background & Aims Acute-on-chronic liver failure (ACLF) is one of the most deadly, prevalent, and costly diseases in Asia. However, no prognostic model has been developed that based specifically on data gathered from Asian patients with ACLF. The aim present study was to quantify survival time ACLF among Asians develop a estimate probability death related Methods We conducted retrospective observational cohort analyze clinical 857 ACLF/pre-ACLF who did not undergo transplantation....
Bioartificial liver (BAL) support system has been proposed as potential treatment method for end-stage diseases. We described an improved BAL based on a choanoid fluidized bed bioreactor containing alginate-chitosan encapsulated primary porcine hepatocytes. The feasibility, safety, and efficiency of this device were estimated using allogeneic fulminant hepatic failure (FHF) model. FHF was induced with intravenous administration D-galactosamine. Thirty pigs divided into three groups: (1)...
Abstract Avian influenza A ( H7N9 ) is a severe disease with high mortality. Hypercytokinemia thought to play an important role in the pathogenesis. This study was investigate efficiency of plasma exchange PE + continuous veno‐venous hemofiltration CVVH on removal inflammatory mediators and their benefits management fluid overload metabolic disturbance. In total, 40 ‐infected patients were admitted our hospital. Sixteen critically ill received combination . Data from these 16 collected...
Three-phase lead zirconate titanate (PZT, PbZr0.52Ti0.48O3)-epoxy-multi-walled carbon nanotube (MWCNT) bulk composites were prepared, where the volume fraction of PZT was held constant at 30%, while MWCNTs varied from 1.0%–10%. The samples poled using either a parallel plate contact or contactless (corona) poling technique. piezoelectric strain coefficient (d33), dielectric (ε), and loss tangent (tan δ) measured 110 Hz, compared as function technique MWCNTs. highest values for coefficients...
This study aimed to establish a diagnostic algorithm combining T-SPOT with computed tomography image analysis based on deep learning (DL) for early differential diagnosis of nontuberculous mycobacteria pulmonary disease (NTM-PD) and tuberculosis (PTB).A total 1049 cases were enrolled, including 467 NTM-PD 582 PTB cases. A 320 (160 160 PTB) randomized as the testing set analyzed using combined DL model. The first divided into T-SPOT-positive -negative groups, model was then used separate four...
Summary. The aims of this study were to investigate the viral differences among lamivudine‐resistant hepatitis B virus (HBV) genotypes and C in vivo . Fifty‐three patients carrying HBV enrolled study. genotypes, Levels alanine aminotransferase (ALT), DNA levels monitored during therapy. polymerase precore/core promoter genes amplified by chain reaction their products sequenced directly. Among 53 resistant accounted for 41.50% 58.50%, respectively. occurrence reverse transcriptase rt204I...
BACKGROUNDAdenoma polyposis coli (APC) mutation is associated with tumorigenesis via the Wnt signaling pathway. AIMTo investigate clinical features and mechanism of APC expression in gastric cancer (GC). METHODSBased on profile, related genome-wide mRNA expression, microRNA (miRNA) methylation profile GC, relationship between as well prognostic significance were systematically analyzed by multi-dimensional methods. RESULTSWe found that high (APC ) was significantly adverse outcomes T4 GC...
Aim: This study aimed to identify long noncoding RNAs (lncRNAs) with potential be prognostic biomarkers of hepatocellular carcinoma (HCC) by analyzing copy number alterations (CNAs). Methods: RNA Sequencing data 369 HCC patients was downloaded from The Cancer Genome Atlas database and analyzed a series systematic bioinformatics methods. Results: LncRNA-CNA association analysis revealed that many lncRNAs were located in sites frequently amplified or deleted. Three upregulated (LINC00689,...
AIM:To construct and evaluate the functionality of a choanoid-fluidized bed bioreactor (CFBB) based on microencapsulated immortalized human hepatocytes.METHODS: Encapsulated hepatocytes were placed in constructed CFBB circulated through Dulbecco's Modified Eagle's Medium (DMEM) for 12 h, then exchanged plasma 6 compared with encapsulated cells cultivated under static conditions spinner flask.Levels alanine aminotransferase (ALT) albumin used to during media circulation, whereas levels ALT,...
Background and objective.The liver-specific functions of hepatocytes are improved by co-culturing with primary hepatic stellate cells (HSC).However, HSC have a short lifespan in vitro, which is considered major limitation for their use various applications.This study aimed to establish immortalized human using the simian virus 40 large T antigen (SV40LT) applications vitro.Methods.Primary were transfected recombinant retrovirus containing SV40LT.The characterized analyzing gene expression...
Background/Aims Microencapsulated hepatocytes have been proposed as promising bioactive agents for packed-bed or fluidized-bed bioartificial liver assist devices (BLADs) and hepatocyte transplantation because of the potential advantages they offer high mass transport rate an optimal microenvironment culture. We developed a large-scale high-production alginate-chitosan (AC) microcapsule roller bottle culture system encapsulation HepLL immortalized human hepatocytes. In this study, efficacy...
PZT-epoxy-multiwalled carbon nanotube (MWCNT) flexible thick film actuators were fabricated using a sol-gel and spin coat deposition process. Films characterized in terms of their piezoelectric dielectric properties as function MWCNT volume fraction polarization Correlations between surface treatment the MWCNTs composite performance made. The morphology filler distribution observed with aid SEM TEM images. PZT was held constant at 30%, varied from 1% to 10%. Two forms compared. Corona...