A5101435071- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
- Herpesvirus Infections and Treatments
- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- interferon and immune responses
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- bioluminescence and chemiluminescence research
- Toxoplasma gondii Research Studies
- Cancer Genomics and Diagnostics
- Neurological disorders and treatments
- Ergonomics and Musculoskeletal Disorders
- Inflammasome and immune disorders
Nanjing Agricultural University
2016-2025
Harbin Medical University
2022-2025
Shandong University of Traditional Chinese Medicine
2023-2024
Northwestern University
2024
Circadian (United States)
2024
Chongqing University of Technology
2024
Peking University
2022-2024
Jiangsu University
2023-2024
Affiliated Hospital of Jiangsu University
2023-2024
Beijing Institute of Big Data Research
2024
In spite of decades-long studies, the mechanism morphogenesis plus-stranded RNA viruses belonging to genus Enterovirus Picornaviridae, including poliovirus (PV), is not understood. Numerous attempts identify an encapsidation signal have failed. Genetic however, implicated a role non-structural protein 2C(ATPase) in formation particles. Here we report novel which protein-protein interaction sufficient explain specificity PV encapsidation. Making use "reporter virus", show that...
Alpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts has developed multiple strategies to counteract the host defense. Here, we demonstrate that tegument protein UL21 (unique long region 21) pseudorabies virus (PRV) dampens type I interferon signaling by triggering degradation CGAS (cyclic GMP-AMP synthase) through macroautophagy/autophagy-lysosome pathway. Mechanistically, scaffolds E3 ligase UBE3C (ubiquitin E3C) catalyze K27-linked ubiquitination at...
Mitochondria, recognized as the "powerhouse" of cells, play a vital role in generating cellular energy through dynamic processes such fission and fusion. Viruses have evolved mechanisms to hijack mitochondrial function for their survival proliferation. Here, we report that infection with swine arterivirus porcine reproductive respiratory syndrome virus (PRRSV), manipulates mitochondria calcium ions (Ca2+) induce mitophagy, thereby reprogramming metabolism facilitate its own replication....
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused several outbreaks in China since 2006. However, the genetic diversity of PRRSV greatly increased by rapid evolution or recombination events. Modified live-attenuated vaccines are widely used to control this disease worldwide. Although risk inefficacy vaccine been reported, between epidemic field strains not completely elucidated. A total 293 clinical samples were collected from 72 pig farms 16 provinces 2015 for...
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens affecting many swine-producing regions. Current vaccination strategies antiviral drugs provide only limited protection. PRRSV infection can cleave mitochondrial signaling protein (MAVS) inhibit induction type I interferon. The effector molecules that are involved in host protective responses to not fully understood. Here, by using transcriptome sequencing, we found a zinc finger...
The poliovirus (PV) eradication campaign is conducted on the premise that this virus, because of lack a zoonotic reservoir, will not reemerge once eradicated. This report examines origin PV using theoretical and experimental approaches. Our rooted phylogenetic analysis suggests speciation from C-cluster coxsackie A virus (C-CAV) ancestor through mutation capsid caused receptor switch intercellular adhesion molecule-1 to CD155, leading change pathogenicity. hypothesis supported experimentally...
The activation of G-protein-coupled olfactory receptors on the sensory neurons (OSNs) triggers a signaling cascade, which is mediated by heterotrimeric G-protein consisting α, β, and γ subunits. Although its α subunit, Gαolf, has been identified well characterized, identities β subunits their function in signal transduction, however, have not established yet. We, others, found expression Gγ13 epithelium, particularly cilia OSNs. In this study, we generated conditional gene knock-out mouse...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a prevalent endemic swine pathogen that causes significant economic losses in the global industry. Commercial vaccines provide limited protection against this virus, no highly effective therapeutic drugs are yet available. In study, we first screened library of 386 natural products found xanthohumol (Xn), prenylated flavonoid hops, displayed high anti-PRRSV activity by inhibiting PRRSV adsorption onto internalization into cells....
Background The highly pathogenic H5N1 avian influenza emerged in the year 1996 Asia, and has spread to Europe Africa recently. At present, effective monitoring data analysis of are not sufficient Chinese mainland. Methodology/Principal Findings During period from April 2004 August 2007, we collected 14,472 wild bird samples covering 56 species 10 orders 14 provinces China monitored prevalence flu virus based on RT-PCR specific for subtype. 149 positive involved six orders. Anseriformes had...
Porcine reproductive and respiratory syndrome (PRRS) has devastated the pig industry worldwide for almost 25 years, its virus (PRRSV) preferentially infects replicates in pulmonary alveolar macrophages (PAMs). To discover cellular protein responses PRRSV-infected PAMs, two-dimensional liquid chromatography–tandem mass spectrometry coupled with isobaric tags relative absolute quantification (iTRAQ) labeling was employed to quantitatively identify differentially expressed proteins between...
Polypeptide 2C(ATPase) is one of the most thoroughly studied but least understood proteins in life cycle poliovirus. Within protein, multiple functional domains important for uncoating, host cell membrane alterations, and RNA replication encapsidation have previously been identified. In this study, charged to alanine-scanning mutagenesis was used generate conditional-lethal mutations hitherto-uncharacterized polypeptide, particularly those involved morphogenesis. Adjacent or clustered amino...
Enteroviruses (EVs) are important human pathogens associated with various clinical syndromes. This study represents an overview of non-polio enteroviruses (NPEVs) isolated from acute flaccid paralysis (AFP) surveillance in Shandong Province, China 1988 to 2013. Altogether 792 and 170 NPEV isolates were stool specimens 9263 AFP cases 1059 contacts, respectively. Complete VP1 sequencing typing on all 962 revealed 53 types which echovirus (E) 6 (7.6%), E14 E11 (7.4%), coxsackievirus (CV) B3 E25...