A5013312806- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Animal Virus Infections Studies
- Animal Genetics and Reproduction
- Liver physiology and pathology
- Ocular Oncology and Treatments
- Ubiquitin and proteasome pathways
- Advanced Breast Cancer Therapies
- Synthesis and biological activity
- Peripheral Artery Disease Management
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Hepatitis B Virus Studies
- Fungal Plant Pathogen Control
- Cardiac Imaging and Diagnostics
- Neuroblastoma Research and Treatments
- Healthcare Systems and Public Health
Peking University First Hospital
2016-2025
Peking University
2016-2025
Sichuan University
2020-2025
West China Hospital of Sichuan University
2020-2025
Huanghe Science and Technology College
2024
Shandong Normal University
2024
Army Medical University
2015-2024
Inner Mongolia University of Science and Technology
2024
Baotou Medical College
2024
Laoshan Laboratory
2024
Abstract Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain TRIM28 bound promoted ubiquitination degradation of CDK4/6-phosphorylated protein. SETDB1, a known binding partner, protected p-RB from through the methylated by its Tudor independent methyltransferase activity. SETDB1 was found be...
Large-scale production of biopharmaceuticals by current bioreactor techniques is limited low transgenic efficiency and expression foreign proteins. In general, a bacterial artificial chromosome (BAC) harboring most regulatory elements capable overcoming the limitations, but transferring BAC into donor cells difficult. We describe here use cattle mammary to produce functional recombinant human lactoferrin (rhLF) novel procedure cloning, which employs microinjection generate somatic as cells....
Abstract Background: Our study was designed to elucidate the morbidity trends of prostate cancer in low-incidence countries. Methods: Data on were extracted from 2019 Global Burden Disease study. A cluster analysis growth rates stratified by age conducted, and correlation analyses performed between age-standardized incidence (ASIR), estimated annual percent change (EAPC), socio-demographic index (SDI). Results: Among 35 countries for cancer, predominantly located Asia North Africa, SDI...
Mesenchymal stem cells (MSCs) do not readily migrate to appropriate sites, and this creates a major obstacle for their use in the treatment of graft-versus-host disease (GVHD). Intercellular adhesion molecule-1 (ICAM-1) can guide homing various immune proper anatomical location within secondary lymphoid organs (SLOs), which are niches generating responses or tolerance. MSCs rarely SLOs after intravenous infusion, constitutively low expression ICAM-1. So our previous work, ICAM-1 was...
Abstract The whey protein β-lactoglobulin (BLG) is a major milk allergen which absent in human milk. Here, we for the first time generated DNA-free BLG bi-allelic knockout cow by zinc-finger nuclease (ZFNs) mRNA and produced BLG-free According to allergenicity evaluation of milk, found it can trigger lower allergic reaction Balb/c mice including rectal temperature drop allergen-specific immunoglobulin IgE production; free-milk was easily digested pepsin at 2 min, while control still not...
Our previous study revealed that mesenchymal stem cells (MSCs) can secrete large amounts of the chemokine CCL2 under inflammatory conditions and alleviate idiopathic pneumonia syndrome (IPS) by promoting regulatory CCR2 + CD4 T-cell formation through CCL2‒CCR2 axis. Given abundance macrophages in lung tissue, how these are regulated MSC-based prophylaxis via IPS their interactions with T tissue during allo-HSCT still not fully understood. An mouse model was established, administered. In...
Significance The multiple-domain protein ZMYND8 is well known as a chromatin reader that recognizes methylated, acetylated, and/or mutated histones. Here we report overexpressed in human ccRCC, and it preferentially binds T487-phosphorylated EZH2. We show hypoxia-stimulated or von Hippel–Lindau–deficient cells, binding of EZH2 important for maintenance phosphorylation level, inhibition PRC2 complex formation, enhanced interaction between FOXM1. Our results reveal function recognizing “code”...
MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the failure models. Then it was found that can transdifferentiate into hepatocyte-like cells and these significantly express albumin. Furthermore also fuse with hepatocytes had proliferation activity. However, percentage transdifferentiation higher than fusion. So considered which transdifferentiated hepatocyte-likes played important roles...
Mesenchymal stem cell (MSC) loaded bio-scaffold transplantation is a promising therapeutic approach for bone regeneration and repair. However, growing evidence shows that pro-inflammatory mediators from injured tissues suppress osteogenic differentiation impair formation. To improve MSC-based regeneration, it important to understand the mechanism of inflammation mediated suppression. In present study, we found synovial fluid rheumatoid arthritis patients cytokines including interleukin-1α,...
<b><i>Objective:</i></b> The spike (S) protein of porcine hemagglutinating encephalomyelitis virus<b> </b>(PHEV) may mediate infection by binding to a cellular neural cell adhesion molecule (NCAM). This study aimed identify the crucial domain S1 subunit S that interacts with NCAM. <b><i>Methods:</i></b> Three truncated segments (S<sub>1-291</sub>, S<sub>277-794</sub> and S<sub>548-868</sub>) gene...
Androgen receptor (AR) is a major survival factor for prostate cancer. Inflammation implicated in many cancer types, including Activation of MAP3K7 (also termed TAK1) and downstream IκB kinase β (IKKβ) by proinflammatory cytokines such as TNFα stimulates NF-κB pathways. Paradoxically, often deleted human Here, we demonstrate that AR protein expression lower inflammatory tumor areas compared with non-inflammatory tissues patients Map3k7 knockout increased levels activity the mouse prostate,...
Abstract Background Interindividual variation characterizes the relief experienced by constipation-predominant irritable bowel syndrome (IBS-C) patients following linaclotide treatment. Complex bidirectional interactions occur between gut microbiota and various clinical drugs. To date, no established evidence has elucidated linaclotide. We aimed to explore impact of on identify critical bacterial genera that might participate in efficacy. Methods IBS-C were administered a daily dose 290 µg...
Background Identifying the state-related “neural correlates of consciousness” for anesthetics-induced unconsciousness is challenging. Spatiotemporal complexity a promising tool investigating consciousness. The authors hypothesized that spatiotemporal may serve as but not drug-related electroencephalography (EEG) indicator during an unconscious state induced by different anesthetic drugs (e.g., propofol and esketamine). Methods recorded EEG from patients with (n = 10) esketamine 10). Both...
Rare earth elements (REEs) are widely used in plenty of fields. REEs have significant neurotoxicity and it may adversely affect the development cognitive. For example, neodymium will causing neurological damage through penetrate blood-brain barrier (BBB). However, whether disrupts balance brain-gut axis (BGA) crosstalk affects intestinal microecology disorder host is still unclear. This study investigated neural on children caused by maternal exposure to Neodymium oxide (Nd2O3) during...
Abstract The monoclonal antibody (mAb) against CD20 known as Rituxan is widely used to treat autoimmune diseases and lymphomas. However, further application of faces challenges high production cost, which limits its availability in developing countries. Here, we report a new approach for large recombinant anti-CD20 mAb the milk transgenic cattle (at yield up ~6.8 mg/mL), with ~80% recovery rate >99% purity. Crystallography study showed that our structurally nearly identical only minor...