A5100348672- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Genetics, Bioinformatics, and Biomedical Research
- Ocular Oncology and Treatments
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Data Mining Algorithms and Applications
- Heat shock proteins research
- Multiple and Secondary Primary Cancers
- Cancer Cells and Metastasis
- Artificial Intelligence in Healthcare
- Ferroptosis and cancer prognosis
- Erythrocyte Function and Pathophysiology
- Gene expression and cancer classification
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- FOXO transcription factor regulation
- Prostate Cancer Treatment and Research
- Biosimilars and Bioanalytical Methods
Southeast University
2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Huazhong Agricultural University
2024
Albert Einstein College of Medicine
2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Mayo Clinic
2023
Fudan University Shanghai Cancer Center
2023
Xiamen University
2023
Shenzhen Second People's Hospital
2023
Jiangsu Hengrui Medicine (China)
2022
The nuclear receptor pregnane X (PXR) is activated by a range of xenochemicals, including chemotherapeutic drugs, and has been suggested to play role in the development tumor cell resistance anticancer drugs. PXR also implicated as regulator growth apoptosis colon tumors. Here, we have used xenograft model cancer define molecular mechanism that might underlie PXR-driven malignancy. Activation was found be sufficient enhance neoplastic characteristics, growth, invasion, metastasis, both human...
Abstract Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain TRIM28 bound promoted ubiquitination degradation of CDK4/6-phosphorylated protein. SETDB1, a known binding partner, protected p-RB from through the methylated by its Tudor independent methyltransferase activity. SETDB1 was found be...
Circ-Foxo3 is a circRNA encoded by the human FOXO3 gene and works as sponge for potential microRNAs (miRNAs) to regulate cancer progression. However, role of circ-Foxo3 in esophageal squamous cell (ESCC) not clear. In this study, was lowly expressed lines ESCC tissues. Meanwhile, overexpression inhibited growth, migration, invasion, whether vivo or vitro. Mechanically, we found miRNA target, miR-23a, which negatively correlated with ESCC. Then, luciferase assay confirmed relationship between...
Abstract To estimate the value of FSCN1 in evaluating prognosis and guiding targeted therapy for patients with tongue squamous cell carcinoma (TSCC). Using Oncomine database, we found some genes especially differentially expressed between TSCC samples normal samples. So compared expression lines knocked down cells to observe its influence on viability trans-migration vitro tumor growth vivo. Then measured human cancer tissues adjacent non-carcinoma (ANT) explored relationship clinical...
Hepatocellular carcinoma (HCC) is a highly prevalent malignancy and the third highest contributor to cancer-associated deaths globally. Research has increasingly demonstrated strong correlation between long noncoding RNAs (lncRNAs) incidence progression of HCC. Nonetheless, exact mechanism whereby function lncRNAs in HCC not been elucidated. This study explored pathological role LINC00294 HCC, as well modulatory involved. Based on "The Cancer Genome Atlas (TCGA)" database validation cell...
Circular RNAs (circRNAs) are novel clusters of endogenous noncoding (ncRNAs) that involved in the regulation multiple biological processes diverse types cancers. However, roles and precise mechanisms circRNAs renal cell carcinoma (RCC) occurrence progression have not been clearly elucidated.We identified aberrantly expressed RCC by high-throughput RNA-seq assay used qRT-PCR to test expression level tissues. Loss-of-function experiments were executed detect circPDK1 cells both vivo vitro. RNA...
Background: Emerging studies have indicated that circular RNAs (circRNAs) play important roles in the development of many tumors. CircRNA-scavenger receptor class B member 1 (Circ-SCARB1) was consistently reported as an elevated circRNA RCC tissues. This study focused on examining biological function and molecular mechanism circSCARB1 progression. Methods: Expressions Circ-SCARB1, microRNA (miR)-510-5p, syndecan 3 (SDC3) were detected using a quantitative real-time polymerase chain reaction...
Peroxiredoxin-6 (PRDX6) is frequently found in various cancers. However, its expression and relevance to proliferation, invasion, migration human non-small-cell lung cancer (NSCLC) remain unclear. This study investigated the role novel mechanism of PRDX6 progression an NSCLC cell line (A549).We analyzed adjacent normal tissues explored migration, invasion A549 cells using either a plasmid or small interfering RNA (siRNA). We also assessed effects on epithelial-mesenchymal transition (EMT)...
Abstract Background Although the implications of circular RNAs (circRNAs) with progression diverse pathological conditions have been reported, circRNA players in osteoarthritis (OA) are barely studied. Methods In this study, twenty-five OA patients who received arthroplasty were recruited for cartilage tissue collection. Public microarray data from Gene Expression Omnibus was retrieved identification. An vitro cell model OA-related damages constructed by treating human chondrocytes (CHON-001...
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. As liver cancer often presents no noticeable symptoms in its early stages, most patients are diagnosed at an advanced stage, complicating treatment. Therefore, identification new biomarkers crucial for detection and treatment HCC. Research on exportin-5 (XPO5) could offer avenues diagnosis improve strategies.
Anoctamin 5 (ANO5) is a member of the (ANO) family calcium-activated chloride channels. Although ANO5 expression upregulated in various cancers, its role osteosarcoma remains largely unknown. In this study, bioinformatics analysis, western blot, and immunohistochemical staining revealed that was cell lines tissues, positively associated with tumor size, grade, metastasis. Functional experiments demonstrated inhibition decreased, while overexpression increased, proliferation mobility vitro....
Chronic intestinal inflammation significantly contributes to the development of colorectal cancer and remains a pertinent clinical challenge, necessitating novel therapeutic approaches. Indole-based microbial metabolite mimics Felix Kopp Kortagere 6 (FKK6), which is ligand agonist pregnane X receptor (PXR), was recently demonstrated have PXR-dependent anti-inflammatory protective effects in mouse model dextran sodium sulfate (DSS)-induced acute colitis. Here, we examined potential FKK6...
During genomics life science research, the data volume of whole and algorithm is going bigger bigger, which calculated as TB, PB or EB etc.The key problem will be how to store analyze with optimized way.This paper demonstrates Intel Big Data Technology Architecture help facilitate accelerate research in utilization.Intel defines high performance GenomicsDB for variant call query Lustre filesystem Hierarchal Storage Management store.Based on these great technology, knowledge share exchange...
<div>Abstract<p>Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain TRIM28 bound promoted ubiquitination degradation of CDK4/6-phosphorylated protein. SETDB1, a known binding partner, protected p-RB from through the methylated by its Tudor independent methyltransferase activity....
<div>Abstract<p>Retinoblastoma (RB) protein can exert tumor suppressor functions even when it becomes phosphorylated. It is thus essential to understand how phosphorylated RB (p-RB) expression and function are regulated. Here, we demonstrated that RING finger domain TRIM28 bound promoted ubiquitination degradation of CDK4/6-phosphorylated protein. SETDB1, a known binding partner, protected p-RB from through the methylated by its Tudor independent methyltransferase activity....
<p>Supplementary Figure S1-S8; Supplementary Table S1-S3</p>
<p>Supplementary Figure S1-S8; Supplementary Table S1-S3</p>
During genomics life science research, the data volume of whole and algorithm is going bigger bigger, which calculated as TB, PB or EB etc. The key problem will be how to store analyze with optimized way. This paper demonstrates Intel Big Data Technology Architecture help facilitate accelerate research in utilization. defines high performance GenomicsDB for variant call query Lustre filesystem Hierarchal Storage Management store. Based on these great technology, knowledge share exchange...