A5100385059- Pancreatic function and diabetes
- Vitamin C and Antioxidants Research
- Sirtuins and Resveratrol in Medicine
- Diabetes and associated disorders
- Computational Drug Discovery Methods
- Infant Nutrition and Health
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Diabetes Management and Research
- Vitamin D Research Studies
- Per- and polyfluoroalkyl substances research
- Cancer Mechanisms and Therapy
- Pharmacological Effects and Toxicity Studies
- Genomics, phytochemicals, and oxidative stress
- Fibroblast Growth Factor Research
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
Guilin Medical University
2016-2025
Qingdao University
2022-2025
Qingdao Women and Children's Hospital
2022-2025
Xi'an Jiaotong University
2023
Xihua University
2020-2023
Qilu Hospital of Shandong University
2020-2023
China Medical University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2023
Central South University
2022
Second Xiangya Hospital of Central South University
2022
HDLs protect against the development of atherosclerosis, but underlying mechanisms are poorly understood. HDL and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via ATP-binding cassette transporters ABCA1 ABCG1. Experiments addressing individual roles ABCG1 in atherosclerosis have produced mixed results, perhaps because compensatory upregulation KO models. To clarify role transporter-mediated sterol this disease process, we transplanted BM Abca1–/–Abcg1–/– mice...
Plasma HDL levels are inversely related to the incidence of atherosclerotic disease. Some atheroprotective effects likely mediated via preservation EC function. Whether beneficial on ECs depend its involvement in cholesterol efflux ATP-binding cassette transporters ABCA1 and ABCG1, which promote oxysterols from macrophages, has not been investigated. To address this, we assessed endothelial function Abca1–/–, Abcg1–/–, Abca1–/–Abcg1–/– mice fed either a high-cholesterol diet (HCD) or Western...
Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable. Since niacin is a vitamin cytoprotective and anti-inflammatory functions, this study aimed evaluate possible functional roles underlying mechanisms of action as an anti-COVID-19 -CRC therapy.We used series network pharmacology-based computational analyses understand characterize binding capacity, biological...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19), an epidemic characterized by rapid infection and a high death toll. The clinical diagnosis of patients with COVID-19 has risen sharply, especially in Western countries. Globally, effective treatment for is still limited. Vitamin A (VA) exhibits pharmacological activity the management pneumonia. Thus, we reason that VA may potentially serve as anti-SARS-CoV-2 regimen. In this study, bioinformatics...
In this study, colorectal cancer (CRC)-diseased targets and resveratrol (Res)-associated were combined constructed by the use of grouped databases for identification predicted targets. After production target-functional protein interaction network Res anti-CRC, topological analysis was used to create core anti-CRC. All performed analyses biological function pathway enrichment optimize processes key signaling pathways The resultant five therapeutic anti-CRC identified as kinase B1 (AKT1),...
Sepsis is a life-threatening complication of pneumonia, including coronavirus disease-2019 (COVID-19)-induced pneumonia. Evidence the benefits vitamin C (VC) for treatment sepsis accumulating. However, data revealing targets and molecular mechanisms VC action against are limited. In this report, bioinformatics analysis network pharmacology was conducted to demonstrate screening targets, biological functions, signaling pathways sepsis. As shown in assays, 63 primary causal were identified...
Large-scale production of biopharmaceuticals by current bioreactor techniques is limited low transgenic efficiency and expression foreign proteins. In general, a bacterial artificial chromosome (BAC) harboring most regulatory elements capable overcoming the limitations, but transferring BAC into donor cells difficult. We describe here use cattle mammary to produce functional recombinant human lactoferrin (rhLF) novel procedure cloning, which employs microinjection generate somatic as cells....
Coronavirus disease 2019 (COVID-19) is a fatal and fast-spreading viral infection. To date, the number of COVID-19 patients worldwide has crossed over six million with three hundred seventy thousand deaths (according to data from World Health Organization; updated on 2 June 2020). Although can be rapidly diagnosed, efficient clinical treatment remains unavailable, resulting in high fatality. Some trials have identified vitamin C (VC) as potent compound pneumonia management. In addition,...
Abstract Obesity, a risk to health, is global problem in modern society. The prevalence of obesity was approximately 13% among world’s adult population. Recently, several reports suggested that the interference gut microbiota composition and function associated with metabolic disorders, including obesity. Gut produce board range metabolites involved energy glucose homeostasis, leading alteration host metabolism. However, systematic evaluation relationship between microbiota, metabolite...
The citrus flavonoid hesperidin has been reported to possess a wide range of pharmacological properties. We have investigated the preventive and therapeutic effects on development adjuvant arthritis (AA), rat model rheumatoid (RA). Freund's complete was used induce AA in rats. Secondary paw swelling, polyarthritis index histopathological assessment ankle joints were evaluate Concanavalin-A-induced T-lymphocyte proliferation interleukin (IL)-2 production by splenocytes measured using MTT...
Transcriptomic and LC-MS/MS-based targeted lipidomic analyses were conducted to identify the effects of in utero PFOS exposure on neonatal testes its relation testicular dysfunction adult offspring. Pregnant mice orally administered 0.3 3 μg PFOS/g body weight until term. Neonatal (P1) collected for detection PFOS, subjected omics study. Integrated pathway using DAVID, KEGG, IPA underlined lipid metabolism, oxidative stress cell junction signaling testes. LC-MS/MS analysis showed that levels...
The present study aimed to uncover the pharmacological function and underlying mechanism of puerarin as a potential treatment for COVID-19, using an in silico methodology, including network pharmacology molecular docking. pivotal targets treat COVID-19 were identified included epidermal growth factor receptor (EGFR), tumour necrosis (TNF), protein p53 (TP53), caspase 3 (CASP3), RELA proto-oncogene (RELA), Fos (FOS), 8 (CASP8), prostaglandin-endoperoxide synthase 2 (PTGS2), interleukin (IL2),...