A5102226289- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Blood Coagulation and Thrombosis Mechanisms
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Biochemical and Molecular Research
- RNA modifications and cancer
- Studies on Chitinases and Chitosanases
- Public-Private Partnership Projects
- Platelet Disorders and Treatments
- Biofuel production and bioconversion
- Advanced biosensing and bioanalysis techniques
- Plasma Applications and Diagnostics
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Chromatography in Natural Products
- Wastewater Treatment and Nitrogen Removal
- Neurological Complications and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- GaN-based semiconductor devices and materials
- Medical Imaging Techniques and Applications
Hainan University
2023-2025
University of Macau
2021-2025
Quality Research
2021-2024
Beijing Jiaotong University
2023
Qufu Normal University
2022
West China Medical Center of Sichuan University
2019-2020
Northeast Forestry University
2020
Peking University
2011
McMaster University
1995-2009
Canadian Blood Services
2009
In this study, colorectal cancer (CRC)-diseased targets and resveratrol (Res)-associated were combined constructed by the use of grouped databases for identification predicted targets. After production target-functional protein interaction network Res anti-CRC, topological analysis was used to create core anti-CRC. All performed analyses biological function pathway enrichment optimize processes key signaling pathways The resultant five therapeutic anti-CRC identified as kinase B1 (AKT1),...
Abstract In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction membrane biogenesis. However, the fundamental biological functions of are still far from clear plants. Here, we report genetic characterization three Arabidopsis thaliana genes encoding d-myo-inositol-3-phosphate synthase (MIPS), which catalyzes rate-limiting step de novo synthesis myo-inositol. Each MIPS rescued yeast ino1 mutant,...
Abstract Epigenetic regulation plays a fundamental role in controlling gene expression and maintaining cellular identity. Among epigenetic processes, the translocation of methyltransferases is critical for modification chromatin structure transcriptional activity. The these events mechanisms involved are complex, yet understanding manipulating states. Therefore, novel strategies required detecting visualizing movement interaction within cells. Using enhancer zeste homolog 2 (EZH2)...
Enhancer of zeste homolog 2 (EZH2) is activated in breast cancer, particularly triple-negative cancer (TNBC), and critical for cell invasion. It interacts with embryonic ectoderm development (EED) maintaining stem cells (CSC) epithelial-mesenchymal transition (EMT) properties, hence promoting CSC metastasis. Because the association EZH2 EED promotes catalytic activity EZH2, inhibiting EED-EZH2 interaction a potential therapeutic strategy treating EZH2-dependent cancer. Although several...
Abstract This article was designed by using a network pharmacological approach to reveal the therapeutic targets and molecular mechanisms of oxyresveratrol (Oxyres) treating colorectal cancer (CRC). Furthermore, several bioinformatic findings would be validated. Pathogenetic CRC Oxyres were identified web‐available databases. All identifiable biotargets collected for functional enrichment analyses biological processes signaling pathways CRC. In addition, human CRC, non‐CRC samples, cell line...
Temozolomide (TMZ) is an anticancer agent used to treat glioblastoma, typically following radiation therapy and/or surgical resection. However, despite its effectiveness, at least 50% of patients do not respond TMZ, which associated with repair tolerance TMZ-induced DNA lesions. Studies have demonstrated that alkyladenine glycosylase (AAG), enzyme triggers the base excision (BER) pathway by excising N3-methyladenine (3meA) and N7-methylguanine lesions, overexpressed in glioblastoma tissues...
The critical role of thrombin in the pathogenesis venous and arterial thrombosis, effectiveness glycosaminoglycans as antithrombotic drugs are well known. Antithrombin III is a major inhibitor augmentation its inhibitory actions by heparin basis for clinical uses heparin. Recent experimental studies have demonstrated that another glycosaminoglycan, dermatan sulfate, an effective drug. Dermatan sulfate catalyses inhibition cofactor II. concentrations II higher plasmas individuals with...
The roles of the G-protein-linked thrombin receptor and platelet glycoprotein Ib (GPIb) as α-thrombin-binding sites on platelets remain controversial. α-Thrombin has been proposed to bind both GPIb hirudin-like domain (from which it cleaves NH2-terminal extracellular release a 41-mer peptide (TR-(1-41), where TR is α-thrombin receptor)) initiate activation. Using affinity-purified rabbit anti-human TR-(1-41) IgG immunoblotting, we demonstrated from suspended in Tyrode's buffer containing 2...
Background and Purpose Autophagy is a critical cellular catabolic process in cell homoeostasis brain function. Recent studies indicate that receptor for activated C kinase 1 (RACK1) involved autophagosome formation Drosophila mice, it plays an essential role morphine‐associated memory. However, the exact mechanism of RACK1 morphine‐induced autophagy not fully understood. Experimental Approach SH‐SY5Y cells were cultured morphine, rapamycin, 3‐methyladenine siRNA used to evaluate regulation...
We previously demonstrated that human platelets activated with SFLLRN release PAR-1 activation peptide, PAR-1-(1-41), even in the presence of hirudin. This observation suggests during their activation, generate a protease activates PAR-1. In this study, and -4 peptides were detected 10 s after <or=1.0 nm alpha-thrombin, microm SFLLRN, or 100 AYPGKF added to platelets. When AYGPKF platelets, generation was complete at s. Generation both response 1 alpha-thrombin significantly inhibited by...
Herein, for the first time, we present a novel solution method controllable synthesis of overlooked cubic phase Cu2GeTe3 nanocrystals. The resulting nanocrystals are high quality with monodispersed size and uniform shape. Optical characterization demonstrates that have broad absorption in visible to near-infrared region. Furthermore, an optoelectronic device based on exhibits excellent stability, reproducibility responsivity. synthetic route presented here not only can open new avenue...
Activation of washed human platelets initiated with α-thrombin, SFLLRN, or AYPGKF invariably results in the generation PAR-1-(1−41) and PAR-4-(1−47). PAR-4-(1−47) are amino-terminal peptides generated when PAR-1 -4 cleaved their first extracellular domains after R41 R47, respectively, to expose tethered ligand -4. Since soybean trypsin inhibitor decreases other platelet aggregation-related responses these three agonists, but does not inactivate a trypsin-like proteinase apparently activates...
Abstract In this study, the hydrothermal method was employed to grow CuS submicron on carbon cloth (CC), and photoreduction used Ag nanoparticles flowers, thus forming Ag/CuS/CC catalytic electrode. The application of electrode-coupled dielectric barrier discharge (DBD) plasma in disinfection pathogenic bacteria water studied. electrode exhibits strong antibacterial activity, under an external voltage 30 V, degradation efficiency Bacillus subtilis reaches 99.99% within 15 min without...