A5069429034- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Economic theories and models
- Complex Systems and Time Series Analysis
- Economic Theory and Institutions
- Game Theory and Applications
- Plant nutrient uptake and metabolism
- Experimental Behavioral Economics Studies
- Banking stability, regulation, efficiency
- Complex Network Analysis Techniques
- Polysaccharides and Plant Cell Walls
- Opinion Dynamics and Social Influence
- Evacuation and Crowd Dynamics
- Mobile Crowdsensing and Crowdsourcing
- Process Optimization and Integration
- Optimal Experimental Design Methods
- Soybean genetics and cultivation
- Technology Assessment and Management
- Advanced Computational Techniques and Applications
- Protein Structure and Dynamics
- Photosynthetic Processes and Mechanisms
- Financial Distress and Bankruptcy Prediction
- Plant responses to water stress
- Calcium signaling and nucleotide metabolism
Shanxi Agricultural University
2025
University of Delaware
2018-2023
GlaxoSmithKline (United States)
2022
National Animal Husbandry Service
2022
Columbia University
2015-2018
VIB-UGent Center for Plant Systems Biology
2015-2017
Ghent University
2016
Peking University
1993-2011
University of Electronic Science and Technology of China
2008
Southwest Jiaotong University
2007
The Arabidopsis thaliana endogenous elicitor peptides (AtPeps) are released into the apoplast after cellular damage caused by pathogens or wounding to induce innate immunity direct binding membrane-localized leucine-rich repeat receptor kinases, PEP RECEPTOR1 (PEPR1) and PEPR2. Although PEPR-mediated signaling components responses have been studied extensively, contributions of subcellular localization dynamics active PEPRs remain largely unknown. We used live-cell imaging fluorescently...
Abstract In animal cells, myo-inositol is an important regulatory molecule in several physiological and biochemical processes, including signal transduction membrane biogenesis. However, the fundamental biological functions of are still far from clear plants. Here, we report genetic characterization three Arabidopsis thaliana genes encoding d-myo-inositol-3-phosphate synthase (MIPS), which catalyzes rate-limiting step de novo synthesis myo-inositol. Each MIPS rescued yeast ino1 mutant,...
Sorghum (Sorghum bicolor L.) is an adversity-tolerant crop, but the function of DUF966 gene family in its growth, development, and stress tolerance unclear. The SbDUF966 was identified analyzed using bioinformatics methods this study. We also expression pattern different tissues conditions RNA-seq RT-qPCR. explored post-transcriptional regulatory mechanism by combining it with miRNA analysis. A total six genes were categorized into two groups (Group I Group II). Gene analysis showed that...
The increasing inequality in income and wealth recent years, the associated excessive pay packages of CEOs US elsewhere, is growing concern among policy makers as well common person. However, there seems to be no satisfactory answer, conventional economic theories models, fundamental questions what kind distribution we ought see, at least under ideal conditions, a free market environment, whether this fair. We propose novel microeconomic game theoretic framework that addresses these proves...
Abstract Therapeutic monoclonal antibodies (mAbs) are typically manufactured using mammalian cell cultures in fed‐batch bioreactors, with increasing emphasis on meeting productivity and product quality attribute targets that depend strongly such process variables as nutrient feed rates bioreactor operating conditions. In this article, we identify, categorize, address the challenges of achieving both goals simultaneously, by developing a multivariable, model‐based control system can satisfy...
The δ13C value is regarded as an important indicator for tolerance to drought stress (DS), which a severe abiotic that influences rice productivity. However, exploration of drought-responsive genes (DRGs) related regulation less reported. In this study, we investigated the natural variation in values 102 japonica accessions. Among them, two accessions with contrasting values, Longdao 10 (LD10, DS-tolerant) and Binxu (BX, DS-sensitive), were used further analysis. LD10 possesses better...
Abstract In manufacturing monoclonal antibodies (mAbs), it is crucial to be able predict how process conditions and supplements affect productivity quality attributes, especially glycosylation. Supplemental inputs, such as amino acids trace metals in the media, are reported cell metabolism glycosylation; quantifying their effects essential for effective development. We aim present validate, through a commercially relevant culture process, technique modeling efficiently. While existing models...
Monoclonal antibodies are critically important biologics as the largest class of molecules used to treat cancers, rheumatoid arthritis, and other chronic diseases. Antibody glycosylation is a critical quality attribute that has ramifications for patient safety physiological efficacy-one can be modified by such factors media formulation process conditions during production. Using design-of-experiments approach, we examined effect 2-F-peracetyl fucose (2FP), uridine, galactose on cell growth...
It is very common to observe crowds of individuals solving similar problems with information in a largely independent manner. We argue here that can become "smarter," i.e., more efficient and robust, by partially following the average opinion. This observation runs counter widely accepted claim wisdom deteriorates social influence. The key difference are self-interested, hence, reject feedback does not improve performance. propose control-theoretic methodology compute degree influence, level...
In cell culture process development, we rely largely on an iterative, one-factor-at-a-time procedure based experiments that explore a limited space. Design of (DoE) addresses this issue by allowing us to analyze the effects inputs responses systematically and efficiently. However, DoE cannot be applied directly study time-varying unless impractically large number bioreactors is used. Here, adopt methodology design dynamic (DoDE) incorporate feeding profiles efficiently in late-stage...
The recent financial crisis and the ensuing sovereign debt once again highlighted that understanding potential instabilities in system is of great societal value. Financial instability typically results from positive feedback loops intrinsic to operation system. challenging task identifying, modeling, analyzing causes effects such requires a proper systems engineering perspective lacking remedies proposed literature. We propose signed directed graphs (SDG), modeling methodology extensively...
Regulating emerging industries is challenging, even controversial at times. Under-regulation can result in safety threats to plant personnel, surrounding communities, and the environment. Over-regulation may hinder innovation, progress, economic growth. Since one typically has limited understanding of, experience with, novel technology practice, it difficult accomplish a properly balanced regulation. In this work, we propose control coordination policy called soft regulation that attempts...
Financial instability often results from positive feedback loops intrinsic to the operation of financial system. The challenging task identifying, modeling, and analyzing causes effects such requires a proper systems engineering perspective lacking in remedies proposed recent literature. We propose that signed directed graphs (SDG), modeling methodology extensively used process engineering, is useful framework address this challenge. SDG able represent reveal information missed by more...
Journal Article Defining topological equivalences in protein structures by means of a dynamic programming algorithm Get access Yu Luo, Luo Department Chemistry, Peking UniversityBeijing 100871, PRC Search for other works this author on: Oxford Academic PubMed Google Scholar Luhua Lai, Lai Xiaojie Xu, Xu 1 1To whom correspondence should be addressed Youqi Tang Protein Engineering, Design and Selection, Volume 6, Issue 4, June 1993, Pages 373–376, https://doi.org/10.1093/protein/6.4.373...
Nowadays, there are too much data residing in various automation islands independently installed utilities the past few years. So facing two problems: (1) how to integrate these and transform into meaningful information; (2) manage evolution of integration. The entire integration cant be done one implementation hence should have a long term (LTE) plan. And now industry consensus is that we use CIM facilitate all integrations. How deal with this most challenging issue. utility plug-in...
The widening inequality in income distribution recent years, and the associated excessive pay packages of CEOs U.S. elsewhere, is growing concern among policy makers as well common person. However, there seems to be no satisfactory answer, conventional economic theories models, fundamental question what kind we ought see, at least under ideal conditions, a free market environment whether this fair. We propose game theoretic framework that addresses these questions show lognormal fairest an...
We commonly seek advice in making decisions. However, multiple empirical studies report that, on average, we shift our own initial decision by only 30% toward external after is provided. This "egocentric discounting" particularly counterintuitive because do care a lot about the opinion of peers. There significant literature that attempts to explain egocentric discounting and factors influence this phenomenon; however, unable why numerical value robust across number experimental settings. In...
It is very common to observe crowds of individuals solving similar problems with information in a largely independent manner. We argue here that can become "smarter," i.e., more efficient and robust, by partially following the average opinion. This observation runs counter widely accepted claim wisdom deteriorates social influence. The key difference are self-interested hence will reject feedbacks do not improve their performance. propose control-theoretic methodology compute degree...