A5100604503- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- Nausea and vomiting management
- Cancer, Stress, Anesthesia, and Immune Response
- Airway Management and Intubation Techniques
- Venous Thromboembolism Diagnosis and Management
- Hormonal Regulation and Hypertension
- Ion Channels and Receptors
- Advanced MRI Techniques and Applications
- Photoreceptor and optogenetics research
- Thermal Regulation in Medicine
- Adrenal and Paraganglionic Tumors
- Nematode management and characterization studies
- Ultrasound in Clinical Applications
- Pituitary Gland Disorders and Treatments
Chinese PLA General Hospital
2011-2023
Fujian Academy of Agricultural Sciences
2020
Institute of Crop Sciences
2020
Second Affiliated Hospital of Xi'an Jiaotong University
2019
Chinese People's Liberation Army
2019
Central Hospital of Zibo
2017
Hunan University of Traditional Chinese Medicine
2015
Shanghai University of Traditional Chinese Medicine
2015
China Medical University
2004-2009
Chinese General Hospital College of Nursing and Liberal Arts
2008
Synthetic poly(vinyl alcohol)–chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility.
Abstract Background This study was designed to explore the prevalence and risk factors of preoperative deep venous thromboembolism (DVT) in Chinese elderly with hip fracture. Methods From January 1, 2012, December 31, 2018, 273 patients over 70 years old elective surgery were collected from electronic medical records. Collected data included demographic characteristics, comorbidities, ASA classification, types previous operations, anesthesia, operation time, fracture hemoglobin level,...
Hawk tea has received increasing attention for its unique flavor and potential health benefits, with antioxidant function being one of significant bioactivities. However, the metabolic profiles, components, action mechanisms different types hawk are still unclear. In this study, chemical components five teas were determined using untargeted metabolomics. Then, metabolites their possible revealed by integrating network pharmacology molecular docking. The results showed that profiles various...
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterized by declines in patients after surgery. Previous studies have suggested that surgery contributed to such impairment. It has been proven neuroinflammation may exacerbate surgery-induced impairment aged rats. The free radical scavenger edaravone high blood brain barrier permeability, and was demonstrated effectively remove radicals from the alleviate development of POCD undergoing carotid endarterectomy, suggesting...
Abstract Our study aimed to explore the molecular mechanisms involved in improvement of postoperative cognitive dysfunction (POCD) by dexmedetomidine (DEX). BV2 microglia cells were cultured under normal condition, DEX exposure (0.1 μg/mL), and lipopolysacchride (LPS) treatment μg/mL) or with pretreatment before LPS incubation. For cells, induced markedly increased release pro‐inflammatory cytokines (interleukin [IL]‐1β, IL‐6, tumor necrosis factor‐alpha [TNF‐α]) expressions Toll‐like...
Garcinia Linn. plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover develop them as potential drug candidates. Through screening targeting nitric oxide accumulation in stimulated macrophage, we found that 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TIE) had effect. To understand how TIE elicits its activity, uncovered it significantly inhibits the production (NO) prostaglandin E2 (PGE2) LPS/IFN γ -stimulated...
Endometrial cancer is a common cause of death in gynecological malignancies. Cisplatin clinically chemotherapeutic agent. However, drug-resistance the primary treatment failure.Emodin commonly used to increase sensitivity agents, yet whether Emodin promotes role endometrial has not been studied.CCK-8 kit was utilized determine growth two cell lines, Ishikawa and HEC-IB. The apoptosis level HEC-IB cells detected by Annexin V / propidium iodide double-staining assay. ROS DCFH-DA NADPH oxidase...
Although the neuroprotective effect of ceftriaxone (CTX) has been reported, underlying mechanisms are still uncertain. In this study, we investigated if rats recover better from CTX pretreatment against cerebral ischemia by inhibiting inflammatory response.Rats were pretreated with (200 mg/kg, 1/day, i.p.) for 5 d. At 24 h after end last pretreatment, focal was induced middle artery occlusion (MCAO) 120 min in male Sprague Dawley rats. The neurological deficit scores (NDS) and infarct...
Abstract To investigate the effects of dexmedetomidine (DEX) on lipopolysaccharide (LPS)‐induced neuroinflammation in BV2 microglia. microglial cells were treated with various concentrations DEX (0, 1, 10, and 100 ng/mL) for 1 hour, then incubated presence or absence 0.1 μg/mL LPS 24 hours. Cell viability was assessed by Counting Kit‐8 assays. The expression levels IL‐1β, IL‐6, TNF‐α determined using enzyme‐linked immunosorbent assay (ELISA). expressions TLR4 NF‐кB detected western blotting....
Background: Bone cancer pain (BCP) significantly affects patient quality of life, results in great bodily and emotional pain, creates difficulties follow-up treatment normal life. Transient receptor potential ankyrin 1 (TRPA1) is an essential transduction ion channel related to neuropathic inflammatory pain. However, the role TRPA1 BCP remains poorly understood. This study aimed explore relationship between BCP. Methods: A model was induced by Walker256 cells left tibia. The sham group...
Background: The majority of surgical patients aged 65 years and over are accompanied with underlying conditions, making them susceptible to perioperative cerebral complications. Here, we investigated the clinical value continuous autoregulation (CA) monitoring in protecting against dysfunction elderly undergoing surgery.Methods: This study enrolled 40 (aged ≥65 years) middle-aged 45 64 selected undergo robotic-assisted laparoscopic radical prostatectomy. Cerebral oxygenation was assessed by...
Abstract Objective Propofol is one of the most commonly used intravenous drugs to induce and maintain general anesthesia. In vivo in vitro studies have shown that propofol can affect neuronal growth, leading apoptosis impairing cognitive function. The Abelson nonreceptor tyrosine kinase (c‐Abl) associated with both neuritic plaques neurofibrillary tangles brains patients Alzheimer's disease other neurodegenerative diseases. This study aimed explore effect on neurocognition through its...