A5016600317- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Infectious Aortic and Vascular Conditions
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Parasites and Host Interactions
- MicroRNA in disease regulation
- Parasitic Diseases Research and Treatment
- Advanced Text Analysis Techniques
- Cancer, Hypoxia, and Metabolism
- Vascular Procedures and Complications
- Complex Network Analysis Techniques
- Circular RNAs in diseases
- Radiopharmaceutical Chemistry and Applications
- Advanced Glycation End Products research
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Thyroid and Parathyroid Surgery
- Cardiovascular Function and Risk Factors
- Hippo pathway signaling and YAP/TAZ
Chinese PLA General Hospital
2018-2025
Yangzhou University
2025
Beijing Technology and Business University
2025
Pingjin Hospital
2022-2024
University of Leeds
2024
PLA Academy of Military Science
2023
Beijing Chuiyangliu Hospital
2021
PLA 306 Hospital
2020
Wannan Medical College
2017-2019
Second Affiliated Hospital of Xi'an Jiaotong University
2019
Scavenger receptors have been reported to mediate macrophage adhesion serum-coated plastic surfaces.W e report here that scavenger promote the divalent cation independent of human monocytes and macrophages surfaces coated with non-enzymatically glycated collagen IV but not native IV.Ligands for receptor types I II blocked had no effect on these cells albumin-coated surfaces.US37 promonocyte-like transfected cDNA encoding bovine or I1 adhered glycated-collagen IV.A synthetic peptide...
Endothelial cells in various tissues of the body are often exposed to hypoxic conditions. To examine effects sustained hypoxia on energy metabolism endothelial cells, we have maintained bovine aortic and human umbilical vein an atmosphere containing low oxygen concentrations (14 mmHg) for up 96 h. We report here that under these conditions upregulate their glucose transport activity, consume more glucose, produce greater amounts lactic acid than normoxic cells. Upregulation activity by...
Abstract Lung cancer (LC) is one of the leading causes cancer‐related death in world. miR‐24‐3p plays critical roles many types, including LC. In this study, we first investigated whether promoted LC cell migration and proliferation vitro. We used three bioinformatics algorithms to predict target gene study molecular mechanism by which contributes progression. Then, luciferase reporter assay identify SOX7 was a direct miR‐24‐3p. Moreover, Western blotting quantitative real time‐polymerase...
We have examined the capacity of four different chemoattractants/cytokines to promote directed migration polymorphonuclear leukocytes (PMN) through three-dimensional gels composed extracellular matrix proteins. About 20% PMN migrated fibrin and plasma clots in response a gradient interleukin 8 (IL-8) or leukotriene B4 (LTB4). In contrast, < 0.3% tumor necrosis factor alpha (TNF) formyl-methionyl-leucyl-phenylalanine (FMLP). All chemoattractants stimulated migrate collagen IV basement...
Developing advanced tissue-engineered membranes with biocompatibility, suitable mechanical qualities, and anti-fibrotic anti-inflammatory actions is important for tympanic membrane (TM) repair. Here, we present a novel acoustically transmitted decellularized fish swim bladder (DFB) loaded mesenchymal stem cells (DFB@MSCs) TM perforation (TMP) The DFB scaffolds are obtained by removing the cellular components from original FB, which retains collagen composition that favors cell proliferation....
With the rapid development of e-commerce industry, market competition is becoming increasingly fierce. As a leading enterprise in domestic JD.com must maintain its strong competitiveness. This paper aims to analyze JD.com's logistics costs through charts, deeply cost structure, and reveal problems management. On this basis, further explores how optimize management achieve reduction efficiency improvement, improve profit level, consolidate customer base, thereby expanding broader more stable...
The mortality rate of non-small cell lung cancer (NSCLC) remains high worldwide. miR-21-5p plays an important part in many types, including NSCLC. However, the effect NSCLC tumorigenesis poorly understood. present study investigated whether promoted proliferation vitro. In order to molecular mechanism by which contributes progression, three bioinformatics algorithms were used predict genes targeted. TGFBI was identfieid as a putative direct target cells via luciferase reporter assay....
Chemoattractants differ in their capacity to stimulate neutrophils adhere and migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates closely to, but not into, fibrin gels. Leukotriene B4 (LTB4) loosely We report that α5β1 integrins regulate the different migratory behaviors on gels of response these chemoattractants. fMLP, LTB4, activated neutrophil β1 integrins, as measured by binding mAb 15/7 an activation epitope integrins. Antibodies or...
Abstract Tenascin is an extracellular matrix protein found in adults T cell-dependent areas of lymphoid tissues, sites inflammation, and tumors. We report here that it inhibited chemotaxis chemoattractant-stimulated human monocytes polymorphonuclear leukocytes (PMN) through three-dimensional gels composed collagen I or Matrigel, leukotriene B4-stimulated PMN fibrin gels. The inhibitory effect tenascin on monocyte these matrices was reversed by Abs directed against α5β1 integrins a peptide...
Summary Vaccination of mice with a recombinant protein, Ov ‐ASP‐1, the Onchocerca volvulus homologue activation associated secreted gene family stimulated very high titres both IgG1 and IgG2a without adjuvant. r ‐ASP‐1 was also immuno‐reactive IgG isotypes from O. ‐infected (INF) putatively immune (PI) humans, higher IgG4 in former group. The protein IFN‐γ secretion by PBMC INF PI IL‐5 only INF. Using mouse diffusion chamber model, vaccination resulted partial but significant protection...
We previously reported that rOv-ASP-1, a recombinant Onchocerca volvulus activation associated protein-1, was potent adjuvant for protein or synthetic peptide-based Ags. In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism action. Consistently, full-length spike SARS-CoV receptor-binding domain in presence could effectively induce mixed but Th1-skewed immune response immunized mice. It appears primarily bound to APCs among human PBMCs triggered...
Expression of Na(+)-glucose cotransporters the SGLT-1 type by Xenopus laevis oocytes increased osmotic water permeability (Pf) a factor 1.9-2.8, in presence and absence 5 mM extracellular glucose. The Pf increase was correlated with amount cRNA injected. In expressing SGLT-1, either addition phlorizin to medium or replacement Na+ choline inhibited uptake methyl-alpha-D-glucopyranoside, specific substrate for returned oocyte its level uninjected oocytes. Phlorizin SGLT-1-attributable an...
Aortic dissection (AD) is one of the most fatal cardiovascular emergency. At anatomical level, AD occurs due to formation intimal tears. However, molecular mechanism underlying this phenomenon remains unknown. Angiotensin II (Ang II) a important effector in development disease that acts through binding angiotensin type 1 receptor (AT1R). Yes-associated protein (YAP) was recently recognized as key macrophage activation. To determine whether AT1R and YAP are involved macrophage-induced...