A5100646359- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- Growth Hormone and Insulin-like Growth Factors
- Cleft Lip and Palate Research
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Histone Deacetylase Inhibitors Research
- Viral Infectious Diseases and Gene Expression in Insects
- Breast Cancer Treatment Studies
- Pituitary Gland Disorders and Treatments
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
University of Electronic Science and Technology of China
2024
Sichuan Cancer Hospital
2024
Zhejiang Sci-Tech University
2023
Shanxi Medical University
2022
Second Hospital of Shanxi Medical University
2022
Second People’s Hospital of Huai’an
2020
Xuzhou Medical College
2020
Nanjing Medical University
2019
Jiangsu Province Hospital
2019
Harbin Medical University
2019
Abstract Lung cancer (LC) is one of the leading causes cancer‐related death in world. miR‐24‐3p plays critical roles many types, including LC. In this study, we first investigated whether promoted LC cell migration and proliferation vitro. We used three bioinformatics algorithms to predict target gene study molecular mechanism by which contributes progression. Then, luciferase reporter assay identify SOX7 was a direct miR‐24‐3p. Moreover, Western blotting quantitative real time‐polymerase...
6-Phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3 (PFKFB3) has been reported to be overexpressed in human cancer tissues and promote the proliferation migration of cells. However, role PFKFB3 progression prognosis breast is not yet fully understood. In present study, we investigated specific its preliminary mechanisms action. We first used an immunohistochemistry assay determine that was highly expressed this high level expression involved poor overall survival patients with cancer....
Increasing evidence indicates that microRNAs (miRNAs) play an important role in various tumors by regulating downstream target genes and diverse signaling pathways. Herein, we confirmed miR-1265 expression gastric cancer (GC) using the Cancer Genome Atlas (TCGA) database assessed level of clinical specimens cell lines. We found was negatively correlated with tumor size. Further functional analysis revealed suppresses cellular proliferation autophagy while inducing apoptosis GC cells. A...
MicroRNAs are a class of small non-coding, endogenous RNAs involved in cancer development and progression. MicroRNA-221 (mir-221) has been reported to have both an oncogenic tumor-suppressive role human tumors, but the miR-221 ovarian is poorly understood. In present study, expression levels apoptosis protease activating factor 1 (APAF1) protein 63 samples tissues cell lines, IOSE25, A2780, OVCAR3, SKOV3 3AO were detected by quantitative reverse-transcription polymerase chain reaction...
Aims: We aim to investigate the effects of miR-421 on lipid metabolism in non-small cell lung cancer (NSCLC). Methods: The expression and PTEN mRNA level tumor tissues, adjacent normal human epithelial cells NSCLC lines were detected with reverse transcription quantitative real-time PCR. Results: MiR-421 was increased, reduced remarkably tissues lines. Down-regulated suppressed accumulation, proliferation, migration invasion, whereas overexpression had opposite effects. directly targeted...
We investigated DDX11-AS1 effects on bladder cancer (BLCA) progression to identify a new potential therapeutic target for BLCA. BLCA cases (n = 108) were enrolled. SW780 and J82 cells transfected. Cell counting kit-8 (CCK-8) assay, wound healing assay transwell migration was conducted. cycle apoptosis detected by flow cytometry. Luciferase reporter performed. DDX11-AS1, miR-499b-5p CDK6 mRNA expression in tissues/cells determined quantitative real-time polymerase chain reaction (qRT-PCR). In...
Cervical lymph node metastasis is an important prognostic indicator for papillary thyroid carcinoma (PTC) and affects treatment strategies PTC. lncRNAs essentially contribute to the biological functions of tumors. This study aimed identify associated with cervical prognosis PTC their potential pathophysiological mechanisms.PTC-associated were selected from The Cancer Genome Atlas database, correlations among lncRNAs, metastasis, tumor staging, analyzed in silico. These then validated through...
Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence shown that single nucleotide polymorphisms located pre‑microRNA (miRNA) or mature miRNA may modify various biological processes affect the process carcinogenesis, downregulation neuronal nitric oxide synthase 1 (NOS1) can induce depression. It NOS1 is target gene miR‑146a, rs2910164 G/C polymorphism downregulate expression...
Traditional diagnostic methods have limited efficacy in predicting the prognosis of lung adenocarcinoma (LUAD), T cell immunoreceptor with immunoglobulin and tyrosine-based inhibitory motif domain (TIGIT) is a new biomarker. This study aimed to evaluate TIGIT expression as LUAD biomarker predict patient using pathological feature model.