A5007762424- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Nuclear Receptors and Signaling
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- Medical Research and Treatments
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Inflammatory mediators and NSAID effects
- Hormonal Regulation and Hypertension
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Helicobacter pylori-related gastroenterology studies
- Cardiac pacing and defibrillation studies
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Studies
- Tuberculosis Research and Epidemiology
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Circular RNAs in diseases
Union Hospital
2024
Huazhong University of Science and Technology
2024
Jining First People's Hospital
2007-2018
Yunnan Population and Family Planning Research Institute
2014
GTx (United States)
2013
Zhengzhou University
2010-2012
Shandong First Medical University
2011
Objectives Statins and calcium channel blockers have been proven beneficial toward improvement of endothelial function. The aim this study was to compare the effect combination therapy statin blocker with solo treatment in patients cardiac syndrome X. Methods results Sixty-eight X were divided randomly into three groups: fluvastatin (40 mg/day, n=23), diltiazem (90 n=22), mg/day) n=23). At end 90 days, coronary flow reserve improved groups (fluvastatin-treated group: 23.2%; diltiazem-treated...
Whelming evidence has demonstrated that WW domain containing E3 ubiquitin protein ligase 1 (WWP1) participates in a wide variety of biological processes and is tightly related to the initiation progression many tumors. Currently, although mounting supports role WWP1 tumor promotion tumorigenesis, potential roles its functions gastric carcinoma are not fully understood. Here, we found messenger RNA (mRNA) were highly expressed tissues cells. High mRNA levels differentiation status, TNM stage,...
MAGE-4 is considered as an attractive cancer-testis (CT) antigen for tumour immunotherapy, and it overexpressed in oesophageal carcinoma (EC). To identify MAGE-4-derived HLA-A2 restricted epitopes, native peptides their analogues were predicted with prediction programs. The peptide, p286 (KVLEHVVRV), its analogues, p286-1Y2L p286-1Y2L9L, showed potent binding affinity stability towards HLA-A*0201 molecule. Cytotoxic T lymphocytes (CTLs) induced by p286-1Y2L9L could release IFN-γ ELISPOT...
Cyclooxygenase-2 is a promising target for cancer immunotherapy. Here, we designed the analogues p321-9L and p321-1Y9L (YLIGETIKL) from cyclooxygenase-2-derived native peptide p321. Then, tested binding affinity stability of their ability to elicit specific immune response both in vitro (from PBMCs HLA-A*02⁺ healthy donors) vivo HLA-A2.1/K(b) transgenic mice). Our results indicated that activity cytotoxic T lymphocytes induced by was more potent than In conclusion, epitope analogue,...
Depression has been well established as an independent predictor of mortality and cardiac morbidity rates in patients with coronary artery disease (CAD). Evidence shown that single nucleotide polymorphisms located pre‑microRNA (miRNA) or mature miRNA may modify various biological processes affect the process carcinogenesis, downregulation neuronal nitric oxide synthase 1 (NOS1) can induce depression. It NOS1 is target gene miR‑146a, rs2910164 G/C polymorphism downregulate expression...
Objective To explore the influence of different pacing rate in risht ventricle on quality life.Methods Pacing was based average heart rate(AHR)obtained before implanting pacemaker.Minnestota living with failure questionnaire(MLHFQ)and 6 minutes walk test(6MWT)were performed pacemaker and afer by(AHR-10)bpm,(AHR-5)bpm,(AHR)bpm,(AHR+5)bpm,(AHR+10)bpm respectively one month.Results The total score MLHFQ,the Score physical dimentions,the emotion dimensions lower than...
Objective To investigate the effect of radiofrequency catheter ablation on cardiac function in patients with symptomatic atrial fibrillation. Methods 110 fibrillation (AF) who were admitted into our hospital from July, 2012 to September, 2015 selected but only 95 finally enrolled study. According different treatment methods, subjects divided a drug group (n=31) and (RFCA, n=64). 3 months after operation, left diameter (LAD), ventricular end diastolic (LVEDd), ejection fraction (LVEF),...