A5102910514- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Ginkgo biloba and Cashew Applications
- Science, Research, and Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Granular flow and fluidized beds
- Effects and risks of endocrine disrupting chemicals
- Neuroscience and Neuropharmacology Research
- Robotics and Sensor-Based Localization
- Cardiac Arrhythmias and Treatments
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Advanced Image and Video Retrieval Techniques
- Soil and Unsaturated Flow
- Chromatography in Natural Products
- Antibiotics Pharmacokinetics and Efficacy
- Stochastic Gradient Optimization Techniques
- Gaussian Processes and Bayesian Inference
- Chemical Analysis and Environmental Impact
- Nuclear Receptors and Signaling
Shanghai Municipal Center For Disease Control Prevention
2024
Zhongshan Hospital
2016-2023
Fudan University
2016-2023
Affiliated Hospital of Jining Medical University
2015-2023
Northeast Agricultural University
2023
First Hospital of Jilin University
2023
Jilin University
2023
Northeast Normal University
2022
University of Electronic Science and Technology of China
2022
Ocean University of China
2021
The optimal strategy for persistent atrial fibrillation (PerAF) is poorly defined. We conducted a multicentre, randomized, prospective trial to compare the outcomes of different ablation strategies PerAF.We enrolled 450 patients and randomly assigned them in 1:1:1 ratio undergo pulmonary vein isolation subsequently following three strategies: anatomical guided (ANAT group, n = 150), electrogram (EGM extensive electro-anatomical (EXT 150). primary endpoint was freedom from (AF) lasting longer...
Objectives Statins and calcium channel blockers have been proven beneficial toward improvement of endothelial function. The aim this study was to compare the effect combination therapy statin blocker with solo treatment in patients cardiac syndrome X. Methods results Sixty-eight X were divided randomly into three groups: fluvastatin (40 mg/day, n=23), diltiazem (90 n=22), mg/day) n=23). At end 90 days, coronary flow reserve improved groups (fluvastatin-treated group: 23.2%; diltiazem-treated...
Neuroinflammation-related amyloid-beta peptide (Aβ) accumulation after cerebral ischemia/reperfusion (I/R) accounts for I/R injuries and poststroke dementia. Recently, pyroptosis, a proinflammatory cell death, has been identified as crucial pathological link of injuries. However, whether pyroptosis acts trigger Aβ not yet demonstrated. Blood-brain barrier (BBB) glymphatic system mediated by aquaporin-4 (AQP-4) on astrocytic endfeet are important pathways the clearance in brain, especially...
Abstract The South China Sea (SCS) serves as the main source of moisture for rainfall in Southern (SC) and meridional transport to SC is dominated by wind changes during first rainy season (April–June). El Niño-Southern Oscillation (ENSO) Tropical Northwestern Pacific (TNWP) variability modulate through anomalous anticyclonic circulation over western North strengthening SCS SC. However, our study indicates that not only intermediary which ENSO or TNWP affects but also plays an independent...
Keypoint extraction is a key technique for Visual Simultaneous Localization and Mapping (VSLAM). Recently, Convolutional Neural Network (CNN) has been used in the keypoint improving accuracy. As one of state-of-the-art CNN based techniques, SuperPoint ranked top CVPR2020 image matching challenge. However, use complex makes it difficult to meet real-time performance on mobile platform with limited resource such as robots wearable Augmented Reality (AR) devices. In this work, SuperPoint, we...
We investigated the effects of Apocynum venetum leaf extract (AVLE) on depressive behaviors and neuronal apoptosis in a chronic unpredictable mild stress (CUMS) rat model depression. Rats were randomly divided into six groups: control, stress, fluoxetine, AVLE30, AVLE60, AVLE120. Except for control group, all rats submitted to paradigms four weeks induce behavior. Neuronal was assessed by terminal deoxynucleotidyl transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) method. The...
As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi (JJDHYZ) decoction has long been used to treat movement disorders. The present study evaluated effects JJDHYZ on dopaminergic (DA) neurons and their survival-enhancing microenvironment as well possible mechanisms involved using mouse model Parkinson's disease. In MPTP-lesioned mice, high dosage (34 g/kg/day) attenuated loss DA neurons, reversed dopamine depletion, improved expression glial-derived...
Abstract Objective To report a case of seizure and rapidly progressive cognitive impairment 20 min after intravenous administration levofloxacin. Case summary A 56-year-old woman was admitted to hospital with episodic unconsciousness unresponsiveness. About 4 days ago, she experienced loss consciousness, fell the floor, yelled for 2 min, before first dose The patient developed symptoms seizure. Levofloxacin is synthetic third generation fluoroquinolone used treat various infectious diseases....
Abstract The pathogenesis of Alzheimer’s disease (AD) involves multiple cell types including endothelial cells, glia, and neurons. It suggests that therapy against single target in type may not be sufficient to treat AD therapies with protective effects more effective. Here, we comprehensively investigated the bilobalide on neuroinflammation Aβ degrading enzymes model mouse model. We find inhibits Aβ-induced STAT3-dependent expression TNF-α, IL-1β, IL-6 primary astrocyte culture. Bilobalide...
Bilobalide (BB), a constituent of the Ginkgo biloba extract, is neuroprotective agent with multiple mechanisms action. To further explore potential therapeutic effects BB in stroke, we investigated its on primary astrocytes using oxygen and glucose deprivation-reoxygenation (OGD-R) model. Cell viability was measured by lactate dehydrogenase release assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. death annexin 5 conjgated fluorescein isothiocyanate (V-FITC) assay,...
A dynamic synchrotron X-ray imaging study reveals effective temperature in a vibrated granular medium, which controls the structural relaxation.
Many studies have shown that glycated hemoglobin (HbA1c) is associated with coronary artery disease (CAD). HbA1c was independently related to angiographic severity in Chinese patients CAD after adjusting for other covariates. Some traditional cardiovascular drugs may an impact on this relationship.This retrospective study enrolled a total of 572 who underwent their angiography and had levels measured at the Hospital. The complexity lesions evaluated using Syntax score, subjects were divided...
Depression is the most prevalent psychiatric disorder, which needs deeper mechanism research studies and effective therapy. Zi-Shui-Qing-Gan-Yin (ZSQGY) a traditional Chinese medicine decoction that has been widely used in China treatment of depressive symptoms. The aim study was to examine anti-depressive effects ZSQGY possible action monosodium glutamate (MSG)-induced model corticosterone (CORT)-induced PC12 cell model. Liquid chromatography-mass spectrometry (LC-MS) performed determine...
(2019). RETRACTED ARTICLE: Bilobalide protects H9c2 cell from oxygen-glucose-deprivation-caused damage via upregulation of miR-27a. Artificial Cells, Nanomedicine, and Biotechnology: Vol. 47, No. 1, pp. 2980-2988.
Sheng-Di-Da-Huang Decoction was used as an effective hemostatic agent in ancient China. However, its therapeutic mechanism is still not clear. Inflammatory injury plays a critical role ICH-induced secondary brain injury. After hemolysis, hematoma components are released, inducing microglial activation via TLR4, which initiates the of transcription factors (such NF-κB) to regulate expression proinflammatory cytokine genes. This study aimed verify anti-inflammatory effects on ICH...
Guipi Tang (GPT) is a widely used traditional Chinese medicine that to treat major depressive disorder. However, the molecular mechanisms of its effects remain unclear.This study aimed investigate antidepressant-like GPT and explore underlying mechanisms.Male Sprague-Dawley rats were subjected chronic unpredictable mild stress (CUMS) procedure treated with various doses GPT, fluoxetine treatment as positive control. Behavioural tests (including sucrose preference test, novelty-suppressed...