A5100431808- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Drug Transport and Resistance Mechanisms
- Natural product bioactivities and synthesis
- Pharmaceutical studies and practices
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Advanced Drug Delivery Systems
- Pharmaceutical Economics and Policy
- Supramolecular Self-Assembly in Materials
- Protease and Inhibitor Mechanisms
- Microbial Applications in Construction Materials
- Traditional and Medicinal Uses of Annonaceae
- Drug Solubulity and Delivery Systems
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Micro and Nano Robotics
Zhengzhou University
2010-2024
Ministry of Education of the People's Republic of China
2022
Chinese Center For Disease Control and Prevention
2022
Central South University
2019
Zhengzhou Children's Hospital
2019
Shenyang Pharmaceutical University
2007-2018
University of California, Davis
2012
Nanchang University
2011
First Affiliated Hospital of Nanchang University
2011
Harbin Medical University
2009
Multidrug resistance (MDR) of a tumor is the main cause failure clinical chemotherapy. Herein, we report simple, yet versatile, tumor-targeting "calcium ion nanogenerator" (TCaNG) to reverse drug by inducing intracellular Ca2+ bursting. Consequently, TCaNG could induce bursting in acidic lysosomes cells and then according following mechanisms: (i) specifically accumulates mitochondria, suppressing cellular respiration relieving hypoxia, thus inhibiting P-glycoprotein biosynthesis...
Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However, the efficiency is restricted by limited CRC-related intestine positioning and dense mucus barrier. Here, we present a biological chemotaxis-guided self-thermophoretic nanoplatform that facilitates precise intestinal autonomous penetration. The introduces asymmetric platinum-sprayed mesoporous silica achieve movement in mucus. Furthermore, inspired intense interaction between pathogenic microbes CRC,...
Targeted drug delivery to colon cancer cells can significantly enhance the therapeutic efficiency. Herein, we developed 5-fluorouracil (5-FU)-loaded amino-functionalized mesoporous silica nanoparticle (MSN-NH2)-based galactosylated chitosans (GCs), which are galactose receptor-mediated materials for colon-specific systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy, transmission X-ray diffraction, Fourier transform infrared...
5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation and potential DNA repair tumor cells. Inspired crucial function iron ions in transformation repair, a liposomal nanomedicine ([email protected]/DFO) with ion regulation property was developed boosting PDT 5-ALA, which prepared co-encapsulating DFO...
Nirmatrelvir/ritonavir is approved for the treatment of adults and pediatric patients with mild to moderate COVID-19, but information on adverse events associated its use limited. We aim evaluate potential risk nirmatrelvir/ritonavir using FDA Adverse Event Reporting System (FAERS). Disproportionality analysis was performed reporting odds ratio (ROR) method, subset based patient age gender, as well sensitivity restricting type reporter healthcare professionals. most commonly reported...
Targeted drug delivery to colon cancer cells can significantly improve the efficiency of treatment. We firstly synthesized carboxyl-modified mesoporous silica nanoparticles (MSN⁻COOH) via two-step synthesis, and then developed calcium leucovorin (LV)-loaded based on galactosylated chitosan (GC), which are galectin receptor-mediated materials for colon-specific systems. Both unmodified functionalized were characterized by scanning electron microscopy (SEM), transmission microscope (TEM),...
Direct factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, commonly used direct oral anticoagulant (DOAC), are widely to prevent treat stroke venous thromboembolic events in patients with atrial fibrillation (AF). This study aimed assess compare reports of adverse associated including hemorrhagic non-hemorrhagic events.
A novel method, named as the plasma protein-interaction QSAR analysis (PPI-QSAR) was used to construct models for human protein binding. The intra-molecular descriptors of drugs and inter-molecular interaction resulted from docking simulation between drug molecules serum albumin were included independent variables in this method. structure-based silico model a data set 65 antibiotic constructed by multiple linear regression method validated residual analysis, normal Probability-Probability...
The use of chemotherapy combined with photothermal therapy (PTT) is getting a focus topic for cancer treatment. Duing this research, the double targeting drug delivery system nedaplatin (NDP)–carboxyl-functionalized magnetic mesoporous silica (MMSN-COOH)–galactosylated chitosan (GC) nanoparticles (NPs) was constructed. Because MMSNs have special physical properties, it can target to specific area. In addition, it’s able convert absorbed near-infrared (NIR) light into heat energy (PTT)....
Background: Th immune response plays an important role in Helicobacter pylori (H. pylori) infection. Tim-1 and Tim-3 are expressed on terminally differentiated Th2 Th1 cells, respectively, participate the regulation of response. Until now, Tim H. infection remains unclear. Materials Methods: (1) Lymphocytes isolated from spleen BALB/c mice were co-cultured with different concentrations viable pylori. Alternatively, challenged by to set up model. (2) The expression mRNA level lymphocytes or...
Gelatin has been considered to exist as intermediate substance of collagen catabolism in tissue remodeling or under inflammatory conditions. We have initiated the study on possible biological functions gelatin that can temporally and locally conditions inflammation Materials methods: To this purpose, we investigated cell proliferation survival gelatin-coated dishes response tumor necrosis factor α (TNFα)-induced cytotoxicity L929 cells. Autophagy level, ATP ROS generation are examined.L929...
The elemene-type terpenoids, which possess various biological activities, contain a syn- or anti-1,2-dialkenylcyclohexane framework. An efficient synthetic route to the and core its application in synthesis of (±)-geijerone diastereomer is reported. Construction anti-1,2-dialkenyl moiety was achieved via Ireland-Claisen rearrangement (E)-allylic ester, cyclohexanone derived from iodoaldehyde intramolecular Barbier reaction. strategy allows rapid access epimers analogues products.