A5087740012- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Healthcare professionals’ stress and burnout
- Diet and metabolism studies
- Workplace Health and Well-being
- Diet, Metabolism, and Disease
- Pulmonary Hypertension Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes and associated disorders
- Dementia and Cognitive Impairment Research
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heme Oxygenase-1 and Carbon Monoxide
- Receptor Mechanisms and Signaling
- Musculoskeletal synovial abnormalities and treatments
- Effects of Vibration on Health
- Synthesis and Reactions of Organic Compounds
- Health and Well-being Studies
- Technostress in Professional Settings
- Hydrogen's biological and therapeutic effects
- Ginseng Biological Effects and Applications
Shenzhen Institutes of Advanced Technology
2024-2025
Chinese Academy of Sciences
2025
South China Agricultural University
2025
Central South University
2015-2024
Chongqing University
2024
Guangdong Pharmaceutical University
2021
National University of Singapore
2015
Ningde Normal University
2013
In the nervous system, excessive activation of NMDA receptors causes neuronal injury. Although NMDARs has been proposed to contribute progress diabetes, little is known about effect long-term on β-cells, especially under challenge hyperglycemia. Here we thoroughly investigated whether endogenous glutamate aggravated β-cell dysfunction chronic exposure high-glucose via NMDARs. The level was increased in plasma diabetic mice or patients and supernatant lines after treatment with for 72 h....
Background Glutamate is a major neurotransmitter in the central nervous system (CNS). Large amount of glutamate can overstimulate N-methyl-D-aspartate receptor (NMDAR), causing neuronal injury and death. Recently, NMDAR has been reported to be found lungs. The aim this study examine effects memantine, channel blocker, on bleomycin-induced lung mice. Methods C57BL/6 mice were intratracheally injected with bleomycin (BLM) induce injury. Mice randomized receive saline, memantine (Me), BLM, BLM...
<title>Abstract</title> Yohimbine, a potent alpha2A-adrenergic receptor (α2AAR) antagonist, was found to carry therapeutic potential for type 2 diabetes through improving insulin release. However, adverse side effects mediated by its actions in the brain hampered use. Here, we have developed novel peripherally acting α2AAR CDS479-2, based on molecular docking analysis and modification of yohimbine's structure. The inactive-state structures α2AAR, either bound yohimbine, or were elucidated...
Acute lung injury (ALI) is a severe health issue with significant morbidity and mortality. Artemisinin used for the treatment of fever malaria in clinical practice. Dihydroartemisinin (DHA), major active metabolite artemisinin, plays role anti‑organizational fibrosis anti‑neuronal cell death. However, whether DHA can attenuate ALI remains unclear. The current study thus examined effects on primary macrophages. results revealed that attenuated lipopolysaccharide (LPS)‑induced pulmonary...
Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, physiological functions regulators these processes remain largely elusive. Evidence suggested that glutamate/N-methyl-D-aspartic acid receptor (NMDAR) axis contributes to acute lung injury, pulmonary arterial hypertension, diabetes, but specific metabolic contribution glutamate/NMDAR is not clear. Here we provide data at animal, cellular, molecular levels support role as a...
Idiopathic pulmonary fibrosis (IPF) can severely disrupt lung function, leading to fatal consequences, and there is currently a lack of specific therapeutic drugs. Bergenin an isocoumarin compound with lots biological functions including antioxidant activity. This study evaluated the potential beneficial effects bergenin on investigated possible mechanisms. We found that alleviated bleomycin-induced by relieving oxidative stress, reducing deposition extracellular matrix (ECM) inhibiting...
Currently, the treatment for sepsis-induced acute lung injury mainly involves mechanical ventilation with limited use of drugs, highlighting urgent need new therapeutic options. As a pivotal aspect injury, pathologic activation and apoptosis endothelial cells related to oxidative stress play crucial role in disease progression, NOX4 Nrf2 being important targets regulating ROS production clearance. Echinacoside, extracted from traditional Chinese herbal plant Cistanche deserticola, possesses...
Type 2 diabetes, which features β-cell failure, is caused by the decrease of mass and insulin secretory function. Current treatments fail to halt functional mass. Strategies prevent apoptosis dysfunction are highly desirable. Recently, our group others have reported that blockade N-methyl-d-aspartate receptors (NMDARs) in islets has been proposed progress type diabetes through improving It suggests a sustained activation NMDARs may exhibit deleterious effect on β-cells. However, exact impact...
Abstract Idiopathic pulmonary fibrosis treatments are limited, often with severe side effects, highlighting the need for novel options. Taraxerone has diverse biomedical properties, but its mechanism remains unclear. This study investigates taraxerone's impact and mechanisms involved in bleomycin‐induced mice. After establishing a mouse model, taraxerone was intraperitoneally injected continuously 14–28 days. The vivo antifibrotic antioxidative stress effects of were assessed. In vitro,...
Objective: Long-term inhalation of silica dust particles leads to lung tissue fibrosis, resulting in impaired gas exchange and increased mortality. Silica triggers the aging epithelial cells (AECs), which is a key contributor development pulmonary fibrosis. Myricetin, flavonoid compound extracted from Myrica genus plants, possesses various biological activities, including antioxidant immunomodulatory effects. However, mechanisms underlying myricetin's ability counter senescence fibrosis need...
Endogenous glutamate (Glu) release and N-methyl-d-aspartate (NMDA) receptor (NMDAR) activation are associated with lung injury in different animal models. However, the underlying mechanism is unclear. Bone marrow-derived mesenchymal stem cells (BM-MSCs), which show potential use for immunomodulation tissue protection, play a protective role pulmonary fibrosis (PF) process. Here, we found increased Glu from BM of bleomycin (BLM)-induced PF mice vivo. BLM stimulation also extracellular BM-MSCs...
Accumulating evidence suggest that endoplasmic reticulum (ER) stress is an important mechanism underlying the development of diabetes. We have reported sustained treatment with N-methyl-d-aspartate (NMDA) results in apoptotic β-cell death and impairs insulin secretion. However, molecular responsible for NMDA-induced dysfunction remains largely obscure. Thus, this study aimed to determine whether activation NMDA receptors (NMDARs) causes through ER stress.Primary mouse islets MIN6 pancreatic...
Abstract Pulmonary fibrosis is characterized by the remodeling of fibrotic tissue and collagen deposition, which mainly results from aberrant fibroblasts proliferation trans-differentiation to myofibroblasts. Patients with chronic myelogenous leukemia, myeloproliferative disorder, scleroderma pulmonary complications show megakaryocyte infiltration in lung. In this study, we demonstrated that number CD41 + megakaryocytes increased bleomycin (BLM)-induced lung tissues through Chemokine...
Acute lung injury (ALI) is a severe disease that can lead to acute respiratory distress syndrome (ARDS), characterized by intractable hypoxemia, poor compliance, and failure, severely affecting patients' quality of life. The pathogenesis ALI has not been fully elucidated yet, sepsis an important cause ALI. Among the organ injuries caused sepsis, lungs are earliest damaged ones. Radix cyathulae reported have analgesic, anti-inflammatory, anti-aging effects. Cyasterone extracted from...
The senescence of alveolar epithelial cells (AECs) and fibroblasts plays a pivotal role in the pathogenesis idiopathic pulmonary fibrosis (IPF), condition lacking specific therapeutic interventions. Curculigoside (CCG), prominent bioactive constituent Curculigo, exhibits anti-osteoporotic antioxidant activities. Our investigation aimed to elucidate anti-senescence anti-fibrotic effects CCG experimental delineate its underlying molecular mechanisms. findings demonstrate that attenuates...
Abstract The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression pulmonary fibrosis (PF). While underlying molecular mechanism remains elusive. In this study, we unveiled previously unrecognized myofibroblast during PF. Our investigation revealed heightened expression mesenchyme homeobox 1 (MEOX1) lungs idiopathic (IPF) patients and bleomycin‐induced PF mice. Silencing MEOX1 significantly attenuated vitro , found notable increase transforming growth factor‐β1...
Abstract Background Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there a lack of effective drug treatment. As major cells sepsis-induced ALI, macrophages polarize toward proinflammatory M1 phenotype secrete multiple inflammatory cytokines to accelerate process through nuclear factor kappa-B (NF-κB) NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling pathways. Taraxerone, main component Chinese medicinal Sedum , possesses numerous biological...
Intrauterine growth retardation (IUGR) is closely related to the later development of type 2 diabetes in adulthood. Excessive activation N-methly-D-aspartate receptors (NMDARs) causes excitatory neurotoxicity, resulting neuronal injury or death. Inhibition NMDARs enhances glucose-stimulated insulin secretion and survival islet cells diabetic mouse human islets. Here, we examined whether antenatal blockade by Memantine could decrease risk induced a high-fat (HF) diet at adulthood IUGR rats....