A5100378002- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Muscle metabolism and nutrition
- Genetic and Kidney Cyst Diseases
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Immune Response and Inflammation
- Calpain Protease Function and Regulation
- Pain Mechanisms and Treatments
- Hops Chemistry and Applications
- Atherosclerosis and Cardiovascular Diseases
- Microbial Metabolism and Applications
- Traditional Chinese Medicine Analysis
- Peroxisome Proliferator-Activated Receptors
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Coal and Its By-products
- Metabolism, Diabetes, and Cancer
- Bone fractures and treatments
Shenyang Pharmaceutical University
2017-2024
Inner Mongolia People's Hospital
2021
Shenyang University
2019
National Institutes of Pharmaceutical Research and Development (China)
2016
SUNY Downstate Health Sciences University
2014
Taishan Medical University
2014
Shandong University
2014
State University of New York
2014
Jiangnan University
2014
Qilu Hospital of Shandong University
2012
Skeletal muscle regeneration is a complicated process, requiring the proliferation, migration and differentiation of myoblasts whose processes are highly regulated by extracellular matrix (ECM) surrounding tissues in vivo. However, effects respective ECM components on regulation myoblast behaviors unknown. In this study, we report effect collagen I, major component tissue popular food supplement, mouse C2C12 as well underlying mechanisms. Collagen I (col 1) enhances myogenic cells, but has...
Extracellular matrix (ECM) has a marked influence on adipose tissue development. Adipose formation is initiated with proliferation of preadipocytes and migration before undergoing further differentiation into mature adipocytes. Previous studies showed that collagen I (col I) provides good substratum for 3T3-L1 to grow migrate. However, it remains unclear whether how col regulates adipogenic preadipocytes. This study reports lipid accumulation, representing in vitro adipogenesis the or mouse...
Objective— Phospholipid transfer protein (PLTP) accelerates the development of atherosclerosis in mouse models. We examined role PLTP atherosclerotic plaque stability. Approach and Results— prepared apolipoprotein E double-knockout (PLTP −/− ApoE ) mice. deficiency significantly decreased lesion size reduced monocyte/macrophage infiltration, as well macrophage apoptosis areas. Moreover, it increased fibrous content plaques, which suggests that may affect Importantly, overexpression mediated...
Reactive oxygen species (ROS) participate in various cell responses association with proliferation, migration, differentiation, and death. Extracellular matrix (ECM) serves as cellular microenvironments for many kinds of cells, affecting activities. However, whether or not ECM influences ROS levels has been well studied. In this study, cells are cultured on collagen I molecule-coated (mol. coated) dishes fibrous gel-covered (gel) to explore their influence behaviours. We found that the...
Purpose: Our previous studies indicate that phorbol 12-myristate 13-acetate (PMA)-treated U937 cells cultured on collagen I-coated dishes express lowered production of pro-inflammatory mediators in parallel through reduced reactive oxygen species (ROS) levels. By contrast, PMA-treated gelatin, the denatured collagen, show enhanced mediators, mediated by up-regulating autophagy The present study is aimed to investigate effect ROS levels gelatin-coated surface. Material and methods: MTT assay,...
Extracellular matrix (ECM) molecules have multiple functions; prevention of cytotoxicity, provision mechanical support, cell adhesive substrates and structural integrity in addition to mediation cellular signaling. In this study, we report that the proliferation INS-1 cells cultured on collagen I-coated dishes is enhanced, but it inhibited V-coated dishes. Inhibitory not due apoptosis induction. Silibinin decreases hepatic glucose production protects pancreatic β-cells, as a potential...
Increasing evidence indicates that cancer stem cells (CSCs) are initiators of the occurrence, development, and recurrence malignant tumors. Mitochondria important organelles in eukaryotic cells, not only responsible for converting part energy released during nutrients oxidation into energy-yielding molecule adenosine triphosphate (ATP) to fuel activities cell, but also play essential roles processes such as cell apoptosis cellular proliferation. The mitochondrial-related abnormalities have...
Skeletal muscle regeneration requires extracellular matrix (ECM) remodeling, including an acute and transient breakdown of collagen that produces gelatin. Although the physiological function this process is unclear, it has inspired application gelatin to injured skeletal for a potential pro-regenerative effect. Here, we investigated bi-phasic effect in regeneration, mediated by hormetic effects reactive oxygen species (ROS). Low-dose stimulated ROS production from NADPH oxidase 2 (NOX2)...
Metabolic dysfunction (MD) is a major health problem threatening the life quality of menopausal women. Saffron has been widely used in herb prescriptions for treating syndrome. However, pharmacological effects and mechanisms saffron are poorly understood. Here, we investigated effect crocin, ingredient its active metabolite blood, crocetin, on MD lipid metabolism ovariectomized (OVX) mice 3T3-L1 adipocytes. The present study showed that intragastric treatment crocin prevented weight gain,...